1-chloro-3-(propylsulfanyl)propan-2-ol

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代醇
• 英文名称: 1-chloro-3-(propylsulfanyl)propan-2-ol
• 英文别名: 1-chloro-3-propanylthiopropan-2-ol；n-Propyl-(3-chlor-2-hydroxypropyl)-sulfid；1-Chlor-3-propylmercapto-propan-2-ol；Propyl-(3-chlor-2-hydroxy-propyl)-sulfid；1-Chloro-3(propylsulfanyl)propan-2-ol；1-chloro-3-propylsulfanylpropan-2-ol
• 化学式: C₆H₁₃ClOS
• 分子量: 168.688
• InChiKey: ZBJZFKVFPDUIIH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  45.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-chloro-3-(propylsulfanyl)propan-2-ol 在 sodium hydroxide 作用下， 以 水 、 苯 为溶剂， 生成 1-(p-tolyloxy)-3-(propylsulfanyl)-2-(N,N-diethylaminomethoxy)propane
  参考文献：
  名称：

  Synthesis and Properties of Aminomethoxy Derivatives of 1-(p-Tolyloxy)-3-(propylsulfanyl)propane

  摘要：

  Mannich condensation of 1-(p-tolyloxy)-3-(propylsulfanyl)propane-2-ol with formaldehyde and secondary amines leads to the formation of new aminomethoxy derivatives of 1-(p-tolyloxy)-3-(propylsulfanyl)propane in yield of 68-80%. Antimicrobial activity of the obtained compounds was investigated.

  DOI：

  10.1134/s1070363220010090
• 作为产物：
  描述：

  丙烷-1-硫醇 、 环氧氯丙烷 在 甲烷 作用下， 生成 1-chloro-3-(propylsulfanyl)propan-2-ol
  参考文献：
  名称：

  Nenitzescu; Scarlatescu, Chemische Berichte, 1935, vol. 68, p. 587,590

  摘要：

  DOI：

文献信息

• Nenitzescu; Scarlatescu, Chemische Berichte, 1935, vol. 68, p. 587,590
  作者：Nenitzescu、Scarlatescu

  DOI：——

  日期：——
• Synthesis and Properties of Aminomethoxy Derivatives of 1-Phenoxy-3-(propylsulfanyl)propane
  作者：I. A. Jafarov、E. H. Mammadbayli、K. A. Kochetkov、A. D. Astanova、L. M. Maharramova

  DOI：10.1134/s1070428019090021

  日期：2019.9

  The condensation of 1-phenoxy-3-(propylsulfanyl)propan-2-ol with formaldehyde and secondary aliphatic and heterocyclic amines afforded new aminomethoxy derivatives of 1-phenoxy-3-(propylsulfanyl)- propane in 69-77% yields. The product structure was confirmed by elemental analyses and IR and H-1 and C-13 NMR spectra. The synthesized compounds were assayed as antiseptics against bacteria and fungi and were shown to be more efficient antimicrobial agents than those currently used in medicine.
• Some β-Hydroxypropyl Sulfides and their Derivatives¹
  作者：Thomas K. Todsen、C. B. Pollard、Edward G. Rietz

  DOI：10.1021/ja01165a046

  日期：1950.9
• Synthesis and Properties of Aminomethoxy Derivatives of 1-(p-Tolyloxy)-3-(propylsulfanyl)propane
  作者：E. H. Mammadbayli、I. A. Jafarov、A. D. Astanova、L. M. Maharramova、N. A. Jafarova

  DOI：10.1134/s1070363220010090

  日期：2020.1

  Mannich condensation of 1-(p-tolyloxy)-3-(propylsulfanyl)propane-2-ol with formaldehyde and secondary amines leads to the formation of new aminomethoxy derivatives of 1-(p-tolyloxy)-3-(propylsulfanyl)propane in yield of 68-80%. Antimicrobial activity of the obtained compounds was investigated.