(E)-1-(4-iodophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one | 92855-02-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (E)-1-(4-iodophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
• 英文别名: 1-(4-iodophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one；4'-iodo-4-methoxy-chalcone；4-iodo-4'-methoxychalcone；4'-iodo-4-methoxy-trans-chalcone；4'-Jod-4-methoxy-trans-chalkon；1-(4-Iodophenyl)-3-(4-methoxyphenyl)-2-propen-1-one
• CAS: 92855-02-2
• 化学式: C₁₆H₁₃IO₂
• 分子量: 364.183
• InChiKey: NPPWBGOAHASNSX-NYYWCZLTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (E)-1-(4-iodophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one 在 四(三苯基膦)钯 、 potassium carbonate 、 三乙胺 作用下， 以 1,4-二氧六环 、 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 生成 (E)-3-(4-(2-hydroxyethoxy)phenyl)-1-(4-tributylstannylphenyl)prop-2-en-1-one
  参考文献：
  名称：

  Synthesis and evaluation of ethyleneoxylated and allyloxylated chalcone derivatives for imaging of amyloid β plaques by SPECT

  摘要：

  We report radioiodinated chalcone derivatives as new SPECT imaging probes for amyloid beta (A beta) plaques. The monoethyleneoxy derivative 2 and allyloxy derivative 8 showed a high affinity for A beta(1-42) aggregates with K-i values of 24 and 4.5 nM, respectively. Fluorescent imaging demonstrated that 2 and 8 clearly stained thioflavin-S positive A beta plaques in the brain sections of Tg2576 transgenic mice. In vitro autoradiography revealed that [I-125]2 displayed no clear accumulation toward A beta plaques in the brain sections of Tg2576 mice, whereas the accumulation pattern of [I-125]8 matched with the presence of A beta plaques both in the brain sections of Tg2576 mice and an AD patient. In biodistribution studies using normal mice, [I-125]2 showed preferable in vivo pharmacokinetics (4.82%ID/g at 2 min and 0.45%ID/g at 60 min), while [I-125]8 showed only a modest brain uptake (1.62%ID/g at 2 min) with slow clearance (0.56%ID/g at 60 min). [I-125]8 showed prospective binding properties for A beta plaques, although further structural modifications are needed to improve the blood brain barrier permeability and washout from brain. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2014.03.032
• 作为产物：
  描述：

  (E)-1-(4-(tributylstannyl)phenyl)-3-(4-methoxyphenyl)prop-2-en-1-one 在 碘 作用下， 以 氯仿 为溶剂， 反应 0.5h， 以61%的产率得到(E)-1-(4-iodophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
  参考文献：
  名称：

  Novel chalcones as probes for in vivo imaging of β-amyloid plaques in Alzheimer’s brains

  摘要：

  A novel series of chalcone derivatives for in vivo imaging beta-amyloid plaques in the brain of Alzheimer's disease (AD) were synthesized and characterized. When in vitro binding studies using A beta aggregates were carried out with chalcone derivatives, the binding affinities for A aggregate varied from 3 to 105 nM. The radioiodinated chalcones were successfully prepared through an iododestannylation reaction from the corresponding tributyltin derivatives using hydrogen peroxide as the oxidant in high yields and with high radiochemical purities. Biodistribution studies in normal mice after iv injection of the radioiodinated chalcones displayed high brain uptake (2.0-4.7%ID/g at 2 min) and rapid clearance from the brain (0.2-0.6%ID/g at 30 min), which is highly desirable or amyloid imaging agents. The results in this study suggest that the novel radioiodinated chalcones may be useful amyloid imaging agents for detecting P-amyloid plaques in the brain of AD. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.07.052

文献信息

• A Simple, Modular Synthesis of Substituted Pyridines
  作者：Songbai Liu、Lanny S. Liebeskind

  DOI：10.1021/ja8013743

  日期：2008.6.1

  A simple, modular method to prepare highly substituted pyridines is disclosed. The method employs a cascade reaction comprising (1) a novel N-iminative, Cu-catalyzed cross-coupling of alkenylboronic acids at the N-O bond of alpha,beta-unsaturated ketoxime O-pentafluorobenzoates, (2) electrocyclization of the resulting 3-azatriene, and (3) air oxidation affording highly substituted pyridines in moderate

  公开了一种制备高度取代的吡啶的简单、模块化的方法。该方法采用级联反应，包括 (1) 在 α,β-不饱和酮肟 O-五氟苯甲酸酯的 NO 键上烯基硼酸的新型 N-亚胺基、Cu 催化交叉偶联，(2) 所得 3-氮杂三烯的电环化，和 (3) 空气氧化以中等至极好的分离产率 (43-91%) 提供高度取代的吡啶。原料易得，官能团耐受性非常好。
• Solvent-free synthesis, spectral correlations and antimicrobial activities of some aryl E 2-propen-1-ones
  作者：K. Sathiyamoorthi、V. Mala、S.P. Sakthinathan、D. Kamalakkannan、R. Suresh、G. Vanangamudi、G. Thirunarayanan

  DOI：10.1016/j.saa.2013.04.048

  日期：2013.8

  Totally 38 aryl E 2-propen-1-ones including nine substituted styryl 4-iodophenyl ketones have been synthesised using solvent-free SiO2-H3PO4 catalyzed Aldol condensation between respective methyl ketones and substituted benzaldehydes under microwave irradiation. The yields of the ketones are more than 80%. The synthesised chalcones were characterized by their analytical, physical and spectroscopic

  在微波辐射下，使用无溶剂的SiO2-H3PO4催化的Aldol缩合反应，合成了38个芳基E 2-丙-1-酮，其中包括9个取代的苯乙烯基4-碘苯基酮。酮的产率超过80％。合成的查耳酮以其分析，物理和光谱数据为特征。使用单线性回归分析，已合成的取代苯乙烯基4-碘苯基酮的光谱频率已与哈米特取代基常数，F和R参数相关联。使用Bauer-Kirby方法研究了4-碘苯基查耳酮的抗菌活性。
• Functionalized BF2 chelated azadipyrromethene dyes
  作者：Aurore Loudet、Rakeshwar Bandichhor、Liangxing Wu、Kevin Burgess

  DOI：10.1016/j.tet.2008.01.117

  日期：2008.4

  effectively to give 1h. Spectroscopic properties of these compounds were recorded, and correlations between substituent effects, UV absorbance, fluorescence emissions, and quantum yields were made. Compound 1a was coupled with a fluorescein-alkyne derivative to give the energy transfer cassettes 2 and 3. Both these compounds gave poor energy transfer, and the possible reasons for this were discussed.

  发射近红外线的荧光分子有可能用作生物技术的探针。这种类型的探针的一个相对未充分探索的设计是 aza-BODIPY 染料；进行这项研究是为了加深我们对这些材料以及它们在染料盒系统中的使用方式的理解。因此，制备了氮杂-BODIPY染料1a-g。制备了该系列中第八个化合物 6h 的高级中间体，但它不能与硼有效络合以产生 1h。记录了这些化合物的光谱特性，并建立了取代基效应、紫外吸收、荧光发射和量子产率之间的相关性。化合物 1a 与荧光素-炔衍生物偶联得到能量转移盒 2 和 3。这两种化合物的能量转移都很差，
• [EN] COMPOSITION FOR TREATING DIABETES AND METABOLIC DISEASES AND A PREPARATION METHOD THEREOF<br/>[FR] COMPOSITION POUR LE TRAITEMENT DU DIABÈTE ET DE MALADIES MÉTABOLIQUES, ET SON PROCÉDÉ DE PRÉPARATION
  申请人：UNIV KAOHSIUNG MEDICAL

  公开号：WO2013022951A1

  公开（公告）日：2013-02-14

  Disclosed is a chalcone composition for treating diabetes and metabolic syndromes. In particular, the chalcone compound bound with 2-halogen in ring A significantly decreases the blood glucose level in the in vitro anti-diabetic effect experiment. In the in vivo animal model, the leading chalcone compound can prevent the progression of diabetes and control the blood glucose level, and there is no significant difference in the gains in body weight. Throughout the seven-week administration, there are no hepatic or renal toxicity observed.

  揭示了一种用于治疗糖尿病和代谢综合征的茚素组合物。具体来说，在环A中与2-卤素结合的茚素化合物在体外抗糖尿病效应实验中显着降低了血糖水平。在体内动物模型中，主要的茚素化合物可以预防糖尿病的进展并控制血糖水平，体重增加方面没有显著差异。在为期七周的给药过程中，没有观察到肝脏或肾脏毒性。
• COMPOSITION FOR TREATING DIABETES AND METABOLIC DISEASES AND A PREPARATION METHOD THEREOF
  申请人：Wu Yang-Chang

  公开号：US20140350304A1

  公开（公告）日：2014-11-27

  Disclosed is a chalcone composition for treating diabetes and metabolic syndromes. In particular, the chalcone compound bound with 2-halogen in ring A significantly decreases the blood glucose level in the in vitro anti-diabetic effect experiment. In the in vivo animal model, the leading chalcone compound can prevent the progression of diabetes and control the blood glucose level, and there is no significant difference in the gains in body weight. Throughout the seven-week administration, there are no hepatic or renal toxicity observed.

  本发明公开了一种治疗糖尿病和代谢综合症的查尔酮组合物。特别是，环A中结合有2-卤素的查尔酮化合物在体外抗糖尿病实验中显著降低血糖水平。在体内动物模型中，主要的查尔酮化合物可以预防糖尿病的进展并控制血糖水平，体重增加也没有显著差异。在七周的给药过程中，没有观察到肝脏或肾脏毒性。