5-氨基-2-(2,4-二氯苯氧基)吡啶 | 85686-48-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 5-氨基-2-(2,4-二氯苯氧基)吡啶
• 中文别名: 6-(2,4-二氯苯氧基)吡啶-3-胺
• 英文名称: 6-(2,4-dichloro-phenoxy)-[3]pyridylamine
• 英文别名: 6-(2,4-Dichlor-phenoxy)-[3]pyridylamin；5-amino-2-(2,4-dichlorophenoxy) pyridine；6-(2,4-dichlorophenoxy)pyridin-3-ylamine；6-(2,4-dichlorophenoxy)pyridin-3-amine
• CAS: 85686-48-2
• 化学式: C₁₁H₈Cl₂N₂O
• mdl: MFCD00052643
• 分子量: 255.103
• InChiKey: XBBAKFQNAVTALV-UHFFFAOYSA-N

物化性质

• 沸点：
  400.6±45.0 °C(Predicted)
• 密度：
  1.421±0.06 g/cm3(Predicted)
• 稳定性/保质期：
  按规定使用和贮存的物质不会分解，并能避免与氧化物接触。

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  48.1
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S37/39
• 危险类别码：
  R36/37/38
• 海关编码：
  2933399090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335
• 储存条件：
  请将药品存放在密闭、阴凉、干燥处。

SDS

Name:	6-(2 4-Dichlorophenoxy)pyridin-3-amine 97 % Material Safety Data Sheet
Synonym:
CAS:	85686-48-2

Section 1 - Chemical Product MSDS Name:6-(2 4-Dichlorophenoxy)pyridin-3-amine 97 % Material Safety Data Sheet
Synonym:

---

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
85686-48-2	6-(2,4-Dichlorophenoxy)pyridin-3-amine	97%	unlisted

Hazard Symbols: XI
Risk Phrases: 36/37/38

---

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation. May be harmful if absorbed through the skin.
Ingestion:
May cause irritation of the digestive tract. May be harmful if swallowed.
Inhalation:
Causes respiratory tract irritation. May be harmful if inhaled.
Chronic:
Not available.

---

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.

---

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

---

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

---

Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

---

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 85686-48-2: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

---

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: Not available.
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 111 - 112 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C11H8Cl2N2O
Molecular Weight: 255.1

---

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Hydrogen chloride, chlorine, nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.

---

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 85686-48-2 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
6-(2,4-Dichlorophenoxy)pyridin-3-amine - Not listed by ACGIH, IARC, or NTP.

---

Section 12 - ECOLOGICAL INFORMATION

---

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

---

Section 14 - TRANSPORT INFORMATION

IATA
No information available.
IMO
No information available.
RID/ADR
No information available.

---

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 37/39 Wear suitable gloves and eye/face
protection.
WGK (Water Danger/Protection)
CAS# 85686-48-2: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 85686-48-2 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 85686-48-2 is not listed on the TSCA inventory.
It is for research and development use only.

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  2,3,4,5-四氢-1H-苯并[b]氮杂卓 、 5-氨基-2-(2,4-二氯苯氧基)吡啶 以88%的产率得到N-[6-(2,4-dichlorophenoxy)pyridin-3-yl]-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxamide
  参考文献：
  名称：

  Therapeutic compounds

  摘要：

  本发明提供了公式I的化合物：1其中X，R1，R2，R3，R4，R5和R6具有规范中定义的任何值，以及包含该化合物的制药组合物。该发明还提供了治疗方法以及用于制备公式I化合物的过程和中间体。

  公开号：

  US20030149024A1
• 作为产物：
  描述：

  5-benzyloxycarbonylamino-2-chloropyridine 、 2,4-二氯酚 在 potassium carbonate 作用下， 以 N-甲基乙酰胺 、 甲醇 为溶剂， 生成 5-氨基-2-(2,4-二氯苯氧基)吡啶
  参考文献：
  名称：

  Urea- and thiourea-type compounds

  摘要：

  本发明涉及分子，能够调节酪氨酸信号转导，以防止和治疗与特定酪氨酸激酶相关的细胞增殖障碍或细胞分化障碍，通过抑制一个或多个异常酪氨酸激酶活性。

  公开号：

  US05773459A1

文献信息

• Heterocyclic compounds as ligands of the GABAA receptor
  申请人：——

  公开号：US20030105081A1

  公开（公告）日：2003-06-05

  Disclosed are heterocyclic compounds of the formula 1 and the pharmaceutically acceptable salts thereof wherein the variables A, V, Y, J, E, X, T, G, Q, W, Z, b, n and m are defined herein. These compounds are highly selective agonists, antagonists or inverse agonists for GABA A brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABA A brain receptor.

  揭示了具有以下公式的杂环化合物及其药用可接受的盐，其中变量A、V、Y、J、E、X、T、G、Q、W、Z、b、n和m在此处被定义。这些化合物是GABA A 脑受体的高度选择性激动剂、拮抗剂或逆激动剂，或者是GABA A 脑受体的激动剂、拮抗剂或逆激动剂的前药。
• IMINIPYRIDINE DERIVATIVES AND THEIR USES AS MICROBIOCIDES
  申请人：Worthington Paul Anthony

  公开号：US20110046088A1

  公开（公告）日：2011-02-24

  Compounds of the formula (I) in which the substituents are as defined in claim 1 are suitable for use as microbiocides.

  公式（I）中的化合物，其中取代基如权利要求1所定义的那样，适用于用作微生物杀菌剂。
• Iminipyridine derivatives and their uses as microbiocides
  申请人：Worthington Paul Anthony

  公开号：US08513286B2

  公开（公告）日：2013-08-20

  Compounds of the formula (I) in which the substituents are as defined in claim 1 are suitable for use as microbiocides.

  式(I)中的化合物，其中取代基的定义如权利要求书1所述，适用于用作微生物杀菌剂。
• BENZAZEPINE DERIVATIVES AND THEIR USE AS 5-HT LIGANDS
  申请人：PHARMACIA & UPJOHN COMPANY

  公开号：EP1451176A2

  公开（公告）日：2004-09-01
• NOVEL MICROBIOCIDES
  申请人：Syngenta Participations AG

  公开号：EP2125734A2

  公开（公告）日：2009-12-02