1-3-[(E)-3-(4-hydroxy-3-methoxyphenyl)-2-propenoyl]phenyl-4-phenyl-2,3-dihydro-1H-2-imidazolone | 1245650-13-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 1-3-[(E)-3-(4-hydroxy-3-methoxyphenyl)-2-propenoyl]phenyl-4-phenyl-2,3-dihydro-1H-2-imidazolone
• 英文别名: 3-[3-[(E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]phenyl]-5-phenyl-1H-imidazol-2-one
• CAS: 1245650-13-8
• 化学式: C₂₅H₂₀N₂O₄
• 分子量: 412.445
• InChiKey: UPEXFYNBXNPNLB-ZRDIBKRKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  78.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  间氨基苯乙酮 在 barium hydroxide octahydrate 、 碳酸氢钠 作用下， 以 甲醇 、 乙醇 、 溶剂黄146 为溶剂， 反应 1.58h， 生成 1-3-[(E)-3-(4-hydroxy-3-methoxyphenyl)-2-propenoyl]phenyl-4-phenyl-2,3-dihydro-1H-2-imidazolone
  参考文献：
  名称：

  IMIDAZOLONE-CHALCONE DERIVATIVES AS POTENTIAL ANTICANCER AGENT AND PROCESS FOR THE PREPARATION THEREOF

  摘要：

  本发明提供了一种化合物A的茚酮偶氮酮类抗癌剂，针对五十三种人类癌细胞系。

  公开号：

  US20130066081A1

文献信息

• [EN] IMIDAZOLONE-CHALCONE DERIVATIVES AS POTENTIAL ANTICANCER AGENT AND PROCESS FOR THE PREPARATION THEREOF<br/>[FR] DÉRIVÉS IMIDAZOLONE-CHALCONE COMME AGENTS ANTICANCÉREUX PUISSANTS ET LEUR PROCÉDÉ DE PRÉPARATION
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2011086412A3

  公开（公告）日：2011-10-13
• Synthesis and anti-cancer activity of chalcone linked imidazolones
  作者：Ahmed Kamal、G. Ramakrishna、P. Raju、A. Viswanath、M. Janaki Ramaiah、G. Balakishan、Manika Pal-Bhadra

  DOI：10.1016/j.bmcl.2010.06.097

  日期：2010.8

  A series of novel chalcone linked imidazolones were prepared and evaluated for their anti-cancer activity against a panel of 53 human tumour cell lines derived from nine different cancer types: leukemia, lung, colon, CNS, melanoma, ovarian, renal, prostate and breast. Some of these hybrids (6, 7 and 8) showed good anti-cancer activity with GI(50) values ranging from 1.26 to 13.9 mu M. When breast carcinoma cells (MCF-7) were treated with 10 mu M concentration of compounds TMAC, CA-4, 6 and 8 cell cycle arrest was observed in G2/M phase. Surprisingly, the increased concentration of the same compound to 30 mu M caused accumulation of cells in G0/G1 phase of the cell cycle. (c) 2010 Elsevier Ltd. All rights reserved.
• US8889874B2
  申请人：——

  公开号：US8889874B2

  公开（公告）日：2014-11-18
• IMIDAZOLONE-CHALCONE DERIVATIVES AS POTENTIAL ANTICANCER AGENT AND PROCESS FOR THE PREPARATION THEREOF
  申请人：Ahmed Kamal

  公开号：US20130066081A1

  公开（公告）日：2013-03-14

  The present invention provides Chalcone linked Imidazolone compounds of formula A as anti cancer agent against fifty three human cancer cell lines. wherein

  本发明提供了一种化合物A的茚酮偶氮酮类抗癌剂，针对五十三种人类癌细胞系。