3-aminohept-3-ens-5-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-aminohept-3-ens-5-one
• 英文别名: (Z)-5-aminohept-4-en-3-one；5-amino-hept-4-en-3-one；5-amino-4-hepten-3-one
• 化学式: C₇H₁₃NO
• 分子量: 127.186
• InChiKey: XWSPOKFDHCLBAV-WAYWQWQTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-aminohept-3-ens-5-one 在 三氟甲磺酸三甲基硅酯 、 三乙胺 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 、 1,2-二氯乙烷 为溶剂， 反应 120.0h， 生成 4,6-diethyl-3-phenylpyridin-2-yl nonaflate
  参考文献：
  名称：

  三甲基甲硅烷基三氟甲磺酸盐促进的β-酮烯酰胺的环缩合反应，以及随后的非硝化反应，生成壬基磺酸吡啶-2-基和吡啶-4-基壬酸酯，作为多取代吡啶的柔性前体

  摘要：

  献给恩斯特·绍曼（Ernst Schaumann）教授70岁生日之际 抽象 研究了使用KO t -Bu或三甲基甲硅烷基三氟甲磺酸盐/Hünig碱将β-酮烯酰胺分子内缩合为2-和/或4-吡啶酮衍生物。随后环化产物不被烧蚀，可以通过Suzuki-Miyaura偶联剂轻松纯化并进一步官能化，从而产生新的高度取代的吡啶衍生物。讨论了环缩合的区域选择性对β-酮烯酰胺结构的依赖性。 研究了使用KO t -Bu或三甲基甲硅烷基三氟甲磺酸盐/Hünig碱将β-酮烯酰胺分子内缩合为2-和/或4-吡啶酮衍生物。随后环化产物不被烧蚀，可以通过Suzuki-Miyaura偶联剂轻松纯化并进一步官能化，从而产生新的高度取代的吡啶衍生物。讨论了环缩合的区域选择性对β-酮烯酰胺结构的依赖性。

  DOI：

  10.1055/s-0033-1338548
• 作为产物：
  描述：

  3,5-庚烷二酮 在 氨 、 silica gel 作用下， 以 水 为溶剂， 生成 3-aminohept-3-ens-5-one
  参考文献：
  名称：

  4-羟基吡啶的新的灵活合成：快速获得铜霉素A，E和功能化的吡啶

  摘要：

  简单但未知：1，3-二酮，氨和羧酸是有效合成4-羟基吡啶和相应的壬酸酯衍生物的前体。这为获得各种高度取代的吡啶衍生物（包括抗生素天然产物，如铜霉素A，E和功能化的吡啶）提供了简单而实用的途径（请参阅方案）。

  DOI：

  10.1002/chem.200900939

文献信息

• Synthesis of highly substituted pyrroles via oxidative free radical reactions of β-aminocinnamates
  作者：An-I Tsai、Che-Ping Chuang

  DOI：10.1016/j.tet.2005.12.011

  日期：2006.3

  reactions of β-aminocinnamates are described. Imine radicals produced by tetra-n-butylammonium cerium(IV) nitrate (TBACN) oxidation of enamines undergo efficient addition to the C–C double bond of β-aminocinnamates. This TBACN mediated free radical reaction between β-aminocinnamates and enamines provides a novel method for the synthesis of highly substituted pyrroles. The direct TBACN oxidation of β-aminocinnamates

  描述了β-氨基肉桂酸酯的氧化自由基反应。硝酸四正丁基铵铈（IV）（TBACN）氧化烯胺所产生的亚胺基要经过有效的加成反应，形成β-氨基肉桂酸酯的C-C双键。这种TBACN介导的β-氨基肉桂酸酯和烯胺之间的自由基反应为合成高度取代的吡咯提供了一种新颖的方法。β-氨基肉桂酸酯的直接TBACN氧化有效地产生了二聚产物。
• Novel Dual Action Receptors Antagonists (Dara) at the Ati and Eta Receptors
  申请人：Gupta Ramesh Chandra

  公开号：US20100010035A1

  公开（公告）日：2010-01-14

  The present invention relates to new compounds of the formula [Chemical formula should be inserted here. Please see paper copy] wherein R1, R2, R3, and R31 are as specified herein. The invention also relates to a method for preparation thereof, as well as combinations of the new compounds with previously known agents. The invention also relates to the use of the above-mentioned compounds and combinations for the preparation of a medicament for treating hypertension of different kinds, alleviating organ damage of different kinds, treating or preventing diabetic nephropathy, treating endothelin and angiotensin mediated disorders, and treating prostate cancer.

  本发明涉及一种新的化合物，其化学式为[应在此处插入化学式。请参见纸质副本]，其中R1、R2、R3和R31如本文所述。本发明还涉及一种制备该化合物的方法，以及新化合物与先前已知药剂的组合。本发明还涉及上述化合物和组合物的用途，用于制备治疗不同类型的高血压、缓解不同类型的器官损伤、治疗或预防糖尿病肾病、治疗内皮素和血管紧张素介导的疾病以及治疗前列腺癌的药物。
• FORMALDEHYDE DETECTING MATERIAL, FORMALDEHYDE DETECTOR, FORMALDEHYDE DETECTING METHOD AND FORMALDEHYDE DETECTING REAGENT
  申请人：Daikin Industries, Ltd.

  公开号：EP2085769A1

  公开（公告）日：2009-08-05

  A formaldehyde detector (10) includes a detection reagent that produces a color by reaction with formaldehyde. The detector (10) further includes a detection element (30) including: a base material (31) constituting an optical waveguide through which light propagates while repeating total reflection; and a mesoporous layer (32) that is formed on at least part of a light-reflecting surface constituting a surface of the base material (31) and carries the detection reagent. The detector (10) further includes: a light emitter for emitting light to the base material (31); and a light receiver for receiving light emitted from the base material (31). In addition, the detector (10) includes a signal processing part. The signal processing part receives an optical signal from the light receiver, detects a change in optical property due to color production resulting from a reaction between formaldehyde and the detection reagent, and based on the change in optical property, detects the presence of formaldehyde and concurrently determines the concentration thereof.

  甲醛检测器（10）包括一种通过与甲醛反应产生颜色的检测试剂。检测器 (10) 还包括检测元件 (30)，该元件包括：构成光波导的基底材料 (31)，光通过该基底材料传播，同时重复全反射；以及介孔层 (32)，该介孔层至少形成于构成基底材料 (31) 表面的光反射表面的一部分，并携带检测试剂。检测器（10）还包括：用于向基底材料（31）发射光的光发射器；以及用于接收从基底材料（31）发射的光的光接收器。此外，探测器（10）还包括一个信号处理部分。信号处理部分接收来自光接收器的光信号，检测由于甲醛和检测试剂之间的反应产生颜色而导致的光学性质变化，并根据光学性质变化检测甲醛的存在，同时确定其浓度。
• NOVEL DUAL ACTION RECEPTORS ANTAGONISTS (DARA) AT THE ATI AND ETA RECEPTORS
  申请人：Torrent Pharmaceuticals Ltd

  公开号：EP1996588A1

  公开（公告）日：2008-12-03
• FORMALDEHYDE DETECTOR BODY, FORMALDEHYDE DETECTOR, FORMALDEHYDE DETECTION METHOD AND FORMALDEHYDE DETECTION REAGENT
  申请人：Zhou Haoshen

  公开号：US20100075431A1

  公开（公告）日：2010-03-25

  A formaldehyde detector ( 10 ) includes a detection reagent that produces a color by reaction with formaldehyde. The detector ( 10 ) further includes a detection element ( 30 ) including: a base material ( 31 ) constituting an optical waveguide through which light propagates while repeating total reflection; and a mesoporous layer ( 32 ) that is formed on at least part of a light-reflecting surface constituting a surface of the base material ( 31 ) and carries the detection reagent. The detector ( 10 ) further includes: a light emitter for emitting light to the base material ( 31 ); and a light receiver for receiving light emitted from the base material ( 31 ). In addition, the detector ( 10 ) includes a signal processing part. The signal processing part receives an optical signal from the light receiver, detects a change in optical property due to color production resulting from a reaction between formaldehyde and the detection reagent, and based on the change in optical property, detects the presence of formaldehyde and concurrently determines the concentration thereof.