4-({6-[8-Chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,e]-[1,4]diazepin-5-yl]6-oxo-hexanoylamino}-methyl)-benzoic acid tert-butyl ester | 1414937-77-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 4-({6-[8-Chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,e]-[1,4]diazepin-5-yl]6-oxo-hexanoylamino}-methyl)-benzoic acid tert-butyl ester
• 英文别名: Tert-butyl 4-[[[6-[3-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzodiazepin-11-yl]-6-oxohexanoyl]amino]methyl]benzoate；tert-butyl 4-[[[6-[3-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzodiazepin-11-yl]-6-oxohexanoyl]amino]methyl]benzoate
• CAS: 1414937-77-1
• 化学式: C₃₆H₄₂ClN₅O₄
• 分子量: 644.214
• InChiKey: NORWVZMQSWQVFB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  46
• 可旋转键数：
  11
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  94.6
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-({6-[8-Chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,e]-[1,4]diazepin-5-yl]6-oxo-hexanoylamino}-methyl)-benzoic acid tert-butyl ester 、 利培酮 、 N-hydroxysulfosuccinimide sodium salt 在 1,2-二氯乙烷 作用下， 以 二甲基亚砜 为溶剂， 生成 4-({6-[8-Chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,e]-[1,4]diazepin-5-yl]6-oxo-hexanoylamino}-methyl)-benzoic acid
  参考文献：
  名称：

  CLOZAPINE IMMUNOASSAY

  摘要：

  从氯氮平衍生的新型共轭物和免疫原以及由这些免疫原产生的抗体在生物体液中用于氯氮平和N-去甲基氯氮平的定量和监测的免疫分析中是有用的。

  公开号：

  US20120301973A1

文献信息

• MAGNESIUM HALIDE ADDUCTS, CATALYST COMPONENTS AND CATALYSTS COMPRISING THE SAME, AND PREPARATION PROCESSES THEREOF
  申请人：XIA Xianzhi

  公开号：US20120302708A1

  公开（公告）日：2012-11-29

  A magnesium halide adduct is provided, comprising at least one compound of the formula MgXY, at least one compound of the formula ROH, methanol, at least one modifying agent chosen from DOE and o-hydroxy benzoates, and optionally water. Also provided herein are a catalyst component comprising the magnesium halide adduct, a catalyst for olefin polymerization comprising the catalyst component; the respective processes for preparing the magnesium halide adduct and the catalyst component; use of the magnesium halide adduct for preparing the catalyst component, use of the catalyst component in a catalyst for olefin polymerization and use of the catalyst in olefin polymerization; and a process of olefin polymerization.
• Clozapine Immunoassay
  申请人：Salamone Salvatore J.

  公开号：US20120301974A1

  公开（公告）日：2012-11-29

  Novel conjugates and immunogens derived from clozapine and antibodies generated by these immunogens are useful in immunoassays for the quantification and monitoring of clozapine in biological fluids.
• US8771972B2
  申请人：——

  公开号：US8771972B2

  公开（公告）日：2014-07-08
• US9068026B2
  申请人：——

  公开号：US9068026B2

  公开（公告）日：2015-06-30
• CLOZAPINE IMMUNOASSAY
  申请人：Salamone Salvatore J.

  公开号：US20120301973A1

  公开（公告）日：2012-11-29

  Novel conjugates and immunogens derived from clozapine and antibodies generated by these immunogens are useful in immunoassays for the quantification and monitoring of clozapine and N-desmethylclozapine in biological fluids.

  从氯氮平衍生的新型共轭物和免疫原以及由这些免疫原产生的抗体在生物体液中用于氯氮平和N-去甲基氯氮平的定量和监测的免疫分析中是有用的。