risperidone pamoate | 160390-88-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: risperidone pamoate
• 英文别名: 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one hemipamoate；3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one 4,4'-methylenebis[3-hydroxy-2-naphthalenecarboxylate]；4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid;3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one
• CAS: 160390-88-5
• 化学式: C₂₃H₁₆O₆*C₂₃H₂₇FN₄O₂
• 分子量: 798.868
• InChiKey: KQCMNEVSEBDCSV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.98
• 重原子数：
  59
• 可旋转键数：
  8
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  177
• 氢给体数：
  4
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  利培酮 、 帕莫酸 在 乙醇 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 以yielding 31 g (81%) of 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one 4,4'-methylenebis[3-hydroxy-2-naphthalenecarboxylate](1:1)的产率得到risperidone pamoate
  参考文献：
  名称：

  Method of treating psychotic disorders using risperidone pamoate

  摘要：

  一种治疗精神病障碍的方法，通过给予有效量的利培酮的渗透酸加盐物，其化学式为：##STR1##

  公开号：

  US05723467A1

文献信息

• [EN] ACID ADDITION SALTS OF RISPERIDONE AND PHARMACEUTICAL COMPOSITIONS THEREOF<br/>[FR] SELS D'ADDITION D'ACIDE DE LA RISPÉRIDONE ET COMPOSITIONS PHARMACEUTIQUES DE CEUX-CI
  申请人：TORRENT PHARMACEUTICALS LTD

  公开号：WO2012147035A1

  公开（公告）日：2012-11-01

  The present invention relates to a novel acid addition salt of risperidone, wherein acid counterion is selected from the group consisting of pamoic acid, caproic acid, cypionic acid, decanoic acid, camphor sulfonic acid, enanthic acid, palmitic acid, fusidic acid, gluceptic acid, gluconic acid, lactobionic acid, lauric acid, levulinic acid and valeric acid, a process for the preparation and pharmaceutical composition comprising the same. Further, the invention relates to the use of said pharmaceutical composition comprising the acid addition salt of risperidone in the treatment of patient suffering from psychotic disorders.

  本发明涉及利培酮的一种新型酸盐，其中酸性对离子选自帕莫酸、己酸、环戊酸、癸酸、樟脑磺酸、己酸、棕榈酸、咪唑霉素酸、葡萄糖酸、葡萄糖酸、乳糖酸、月桂酸、戊二酸和戊酸，以及制备该酸盐的方法和包含该酸盐的药物组合物。此外，本发明涉及利用含有利培酮酸盐的药物组合物治疗患有精神疾病的患者。
• ACID ADDITION SALTS OF RISPERIDONE AND PHARMACEUTICAL COMPOSITIONS THEREOF
  申请人：Nadkarni Sunil Sadanand

  公开号：US20140045864A1

  公开（公告）日：2014-02-13

  The present invention relates to a novel acid addition salt of risperidone, wherein acid counterion is selected from the group consisting of pamoic acid, caproic acid, cypionic acid, decanoic acid, camphor sulfonic acid, enanthic acid, palmitic acid, fusidic acid, gluceptic acid, gluconic acid, lactobionic acid, lauric acid, levulinic acid and valeric acid, a process for the preparation and pharmaceutical composition comprising the same. Further, the invention relates to the use of said pharmaceutical composition comprising the acid addition salt of risperidone in the treatment of patient suffering from psychotic disorders.

  本发明涉及利培酮的一种新型酸盐，其中酸性对离子选自帕莫酸、己酸、环戊酸、癸酸、樟脑磺酸、己酸、棕榈酸、咪唑霉素酸、葡萄糖酸、葡萄糖酸、乳糖酸、月桂酸、戊酸和戊酸，以及制备该酸盐的方法和包含该酸盐的药物组合物。此外，本发明涉及利用含有利培酮酸盐的药物组合物治疗患有精神障碍的患者。
• Compositions and medical devices utilizing bioabsorbable liquid polymers
  申请人：——

  公开号：US20030185752A1

  公开（公告）日：2003-10-02

  The present invention is directed to medical devices and pharmaceutical compositions containing a synthetic, bioabsorbable, biocompatible liquid polymer that is the reaction product of a polybasic acid or derivative thereof, a polyol and a fatty acid, the liquid polymer having a melting point less than about 40° C., as determined by differential scanning calorimetry.

  本发明涉及医疗器械和药物组成物，其包含一种合成的、生物可吸收的、生物相容性液态聚合物，该聚合物是由多元酸或其衍生物、多元醇和脂肪酸反应生成的，该液态聚合物的熔点由差示扫描量热法测定小于约40℃。
• COMPOSITIONS AND MEDICAL DEVICES UTILIZING BIOABSORBABLE LIQUID POLYMERS
  申请人：Nathan Aruna

  公开号：US20080075754A1

  公开（公告）日：2008-03-27

  The present invention is directed to medical devices and pharmaceutical compositions containing a synthetic, bioabsorbable, biocompatible liquid polymer that is the reaction product of a polybasic acid or derivative thereof, a polyol and a fatty acid, the liquid polymer having a melting point less than about 40° C., as determined by differential scanning calorimetry.

  本发明涉及医疗器械和制药组合物，其中包含一种合成的、可生物吸收的、生物相容液态聚合物，该聚合物是多酸或其衍生物、多元醇和脂肪酸的反应产物，该液态聚合物的熔点小于约40℃，由差示扫描量热法确定。
• Compositions and medical devices comprising bioabsorbable alkyd-type polymeric waxes
  申请人：ETHICON, INC.

  公开号：EP1270024A1

  公开（公告）日：2003-01-02

  The present invention is directed to medical devices, pharmaceutical or agricultural compositions, and seeds, each containing a synthetic, bioabsorbable, biocompatible alkyd-type polymeric wax that is the reaction product of a polybasic acid or derivative thereof, a polyol and a fatty acid, the polymeric wax having a melting point less than about 70°C, as determined by differential scanning calorimetry.

  本发明涉及医疗器械、药用或农用组合物和种子，每一种都含有合成的、生物可吸收的、生物相容的醇酸型聚合蜡，该聚合蜡是一种多基酸或其衍生物、一种多元醇和一种脂肪酸的反应产物，经差示扫描量热法测定，该聚合蜡的熔点低于约 70°C。