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fluoro-1 hexanone-2 | 371-37-9

中文名称
——
中文别名
——
英文名称
fluoro-1 hexanone-2
英文别名
1-fluoro-hexan-2-one;1-Fluor-hexan-2-on;1-fluoro-2-hexanone;Fluormethylbutylketon;1-fluorohexan-2-one
fluoro-1 hexanone-2化学式
CAS
371-37-9
化学式
C6H11FO
mdl
——
分子量
118.151
InChiKey
REARGOUCOBYKTJ-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 沸点:
    70 °C(Press: 16 Torr)
  • 密度:
    0.907±0.06 g/cm3(Predicted)

计算性质

  • 辛醇/水分配系数(LogP):
    1.7
  • 重原子数:
    8
  • 可旋转键数:
    4
  • 环数:
    0.0
  • sp3杂化的碳原子比例:
    0.83
  • 拓扑面积:
    17.1
  • 氢给体数:
    0
  • 氢受体数:
    2

反应信息

  • 作为反应物:
    描述:
    fluoro-1 hexanone-2咪唑magnesium 、 mercury dichloride 作用下, 生成 4-(Fluoromethyl)-4-((trimethylsilyl)oxy)-1-octyne
    参考文献:
    名称:
    Prostaglandins and congeners. 27. Synthesis of biologically active 16-halomethyl derivatives of 15-deoxy-16-hydroxyprostaglandin E2
    摘要:
    DOI:
    10.1021/jo01300a002
  • 作为产物:
    描述:
    (Z)-1,2-difluoro-1-(trimethylsilyl)-1-hexene硫酸 作用下, 反应 2.0h, 以45%的产率得到fluoro-1 hexanone-2
    参考文献:
    名称:
    Martin, Sophie; Sauvetre, Raymond; Normant, Jean-F., Bulletin de la Societe Chimique de France, 1986, # 6, p. 900 - 905
    摘要:
    DOI:
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文献信息

  • 1-Substituted-1-oxo-prostane-derivatives of the E, A and F series
    申请人:American Cyanamid Company
    公开号:US04297516A1
    公开(公告)日:1981-10-27
    The invention disclosed herein relates to pharmacologically active prostaglandin derivatives of the E, F, or A series having on the terminal methylene carbon of the alpha chain, a substituent selected from the group consisting of: ##STR1## wherein R is C.sub.1 to C.sub.6 alkyl, and phenyl or phenyl substituted with one or more substituents selected from the group consisting of C.sub.1 -C.sub.4 alkyl, OR.sub.16, SR.sub.16, F, or Cl, and R.sub.16 is C.sub.1 to C.sub.6 alkyl.
    本发明公开的药物活性前列腺素衍生物属于E、F或A系列,在α链的末端亚甲基碳上有一个取代基,该取代基从以下组中选择:##STR1## 其中R是C.sub.1至C.sub.6烷基,和苯基或苯基,苯基上带有1个或多个取代基,该取代基从以下组中选择:C.sub.1-C.sub.4烷基,OR.sub.16,SR.sub.16,F或Cl,R.sub.16是C.sub.1至C.sub.6烷基。
  • 1-Hydroxymethyl-1-oxo-prostane-derivatives of the E, A and F-series
    申请人:American Cyanamid Company
    公开号:US04254036A1
    公开(公告)日:1981-03-03
    The invention disclosed herein relates to pharmacologically active prostaglandin derivatives of the E, F, or A series having on the terminal methylene carbon of the alpha chain a substituent selected from the group consisting of: ##STR1## wherein R is an alkyl group and R.sub.15 is C.sub.1 -C.sub.4 alkyl, di-C.sub.1 -C.sub.4 -alkylamino, C.sub.1 -C.sub.4 alkoxy, and phenyl or phenyl substituted with one or more substituents from the group consisting of C.sub.1 -C.sub.4, OR, SR, F, or Cl wherein R is as previously defined.
    本发明涉及具有在α链的末端亚甲基碳上选择自以下组成的取代基的E、F或A系列药理活性前列腺素衍生物:##STR1##其中R是烷基基团,R.sub.15是C.sub.1 -C.sub.4烷基,二C.sub.1 -C.sub.4-烷基氨基,C.sub.1 -C.sub.4烷氧基,苯基或苯基,其上取代基来自C.sub.1 -C.sub.4,OR,SR,F或Cl的组成,其中R如前所定义。
  • 15-Deoxy-16-hydroxy-16-fluoromethyl, difluoromethyl or trifluoromethyl
    申请人:American Cyanamid Company
    公开号:US04228298A1
    公开(公告)日:1980-10-14
    The invention disclosed herein relates to pharmacologically active prostaglandins of the E and F series in which C-16 is substituted with hydroxyl and fluoromethyl, difluoromethyl or trifluoromethyl as well as the pharmacologically acceptable, non-toxic lower alkyl esters and salts thereof, and to the intermediates and processes for producing such compounds.
    本发明涉及药理活性的E和F系列前列腺素,其中C-16被羟基和氟甲基、二氟甲基或三氟甲基取代,以及其药理学上可接受的、非毒性的低烷基酯和盐,以及生产这些化合物的中间体和过程。
  • 1-Hydroxymethyl-1-oxo-prostane derivatives of the E, A and F series
    申请人:AMERICAN CYANAMID COMPANY
    公开号:EP0015056A1
    公开(公告)日:1980-09-03
    The invention disclosed relates to pharmacologically active prostaglandin derivates of the E, F, or A series having on the terminal methylene carbon of the alpha chain a substituent selected from the group consisting of: wherein R is an alkyl group and R13 is C1-C4 alkyl, di-C,-C. -alkylamino, C1-C4 alkoxy, and phenyl or phenyl substituted with one or more substituents from the group consisting of C1-C4, OR, SR, F, or Cl wherein R is as previously defined.
    本发明涉及具有药理活性的 E、F 或 A 系列前列腺素衍生物,其 α 链的末端亚甲基碳上具有选自以下组别的取代基: 其中 R 是烷基,R13 是 C1-C4 烷基、二-C,-C.-烷基氨基、C1-C4 烷氧基和苯基或被一个或多个取代基取代的苯基,取代基可从 C1-C4、OR、SR、F 或 Cl 组成的组中选出,其中 R 如前定义。
  • Olah; Kuhn, Chemische Berichte, 1956, vol. 89, p. 864
    作者:Olah、Kuhn
    DOI:——
    日期:——
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