dimannitol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: dimannitol
• 英文别名: Dimannit；6-(2,3,4,5,6-Pentahydroxyhexoxy)hexane-1,2,3,4,5-pentol
• 化学式: C₁₂H₂₆O₁₁
• 分子量: 346.332
• InChiKey: DPVXEIMDJRZWJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.7
• 重原子数：
  23
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  212
• 氢给体数：
  10
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  dimannitol 、 水 生成 1,4-sorbitan
  参考文献：
  名称：

  Vignon, Annales de Chimie (Cachan, France), 1874, vol. <5> 2, p. 459

  摘要：

  DOI：
• 作为产物：
  描述：

  甘露醇 在 水 作用下， 生成 dimannitol
  参考文献：
  名称：

  Vignon, Annales de Chimie (Cachan, France), 1874, vol. <5> 2, p. 459

  摘要：

  DOI：

文献信息

• HETEROCYCLIC PYRIDONE COMPOUND, AND INTERMEDIATE, PREPARATION METHOD AND USE THEREOF
  申请人：Cheng Jianjun

  公开号：US20140206679A1

  公开（公告）日：2014-07-24

  The present invention relates to a heterocyclic pyridone compound represented by General Formula (I), where the heterocyclic pyridone compound is used as a tyrosine kinase inhibitor, and particularly a c-Met inhibitor. The present invention also relates to intermediates for preparing heterocyclic pyridone compound and a preparation method. The present invention further relates to a pharmaceutical composition containing the heterocyclic pyridone compound as an active ingredient, and a use of the pharmaceutical composition in treatment of diseases associated with tyrosine kinase c-Met, especially cancer associated with c-Met, as a medicament.

  本发明涉及一种由通式(I)表示的杂环吡啶酮化合物，其中该杂环吡啶酮化合物用作酪氨酸激酶抑制剂，特别是c-Met抑制剂。本发明还涉及用于制备杂环吡啶酮化合物的中间体和制备方法。本发明还涉及一种包含杂环吡啶酮化合物作为活性成分的药物组合物，以及药物组合物在治疗与酪氨酸激酶c-Met相关的疾病，特别是与c-Met相关的癌症作为药物的用途。
• Etherification process for hexitols and anhydrohexitols
  申请人：ICI AMERICAS INC.

  公开号：EP0092998A1

  公开（公告）日：1983-11-02

  A high yield process for the polyalkylation of hexitols and hexitol inner ethers is presented wherein aqueous dispersions of monoalkali metal alkoxides thereof in organic solvent are reacted with alkyl monohalides to first form the monoalkylated hexitols or hexitol inner ether and thereafter further alkylated by addition of reactants to form the completely alkylated derivative.

  本发明提出了一种用于己糖醇和己糖醇内醚多烷基化的高产率工艺，其中有机溶剂中的单碱金属烷氧基化物水分散液与烷基单卤化物反应，首先形成单烷基化的己糖醇或己糖醇内醚，然后通过添加反应物进一步烷基化，形成完全烷基化的衍生物。
• US4435586A
  申请人：——

  公开号：US4435586A

  公开（公告）日：1984-03-06
• US9562060B2
  申请人：——

  公开号：US9562060B2

  公开（公告）日：2017-02-07
• [EN] EXTERNAL PREPARATION FOR THE SKIN<br/>[FR] PRÉPARATION EXTERNE POUR LA PEAU
  申请人：SHISEIDO CO LTD

  公开号：WO2009063644A1

  公开（公告）日：2009-05-22

  The purpose of this object is to provide a moisturizing agent which has an extremely high moisturizing effect and a fresh feeling (a feeling of being moisturized) in using and an external preparation for the skin. A moisturizing agent which comprises one or more members selected from among a lower alkyl pentitol ether represented by the general formula (I) and a lower alkyl hexitol ether represented by the following general formula (II); and an external preparation for the skin which contains this moisturizing agent. A-Rm (I) [wherein A represents a pentitol residue remaining after removing m hydrogen atoms; R represents a C1-4 alkyl group (including a hydroxyalkyl group); and m is a number that stands for the average degree of substitution of R and ranges from 1 to 5.] B-Rn (II) [wherein B represents a hexitol residue remaining after removing n hydrogen atoms; R represents a C1-4 alkyl group (including a hydroxyalkyl group); and n is a number that stands for the average degree of substitution of R and ranges from 1 to 6.]