1-(4-溴丁氧基)-4-碘苯 | 299461-38-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 1-(4-溴丁氧基)-4-碘苯
• 英文名称: 1-(4-bromobutoxy)-4-iodobenzene
• CAS: 299461-38-4
• 化学式: C₁₀H₁₂BrIO
• 分子量: 355.013
• InChiKey: NEJRXOXIALLSMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(4-溴丁氧基)-4-碘苯 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 羟胺 、 potassium carbonate 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 N-{4-[4-(4-{4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1-yl}-butoxy)-phenyl]-but-3-ynyl}-hydroxylamine
  参考文献：
  名称：

  5-Lipoxygenase inhibition by N-hydroxycarbamates in dual-function compounds

  摘要：

  A series of N-hydroxycarbamates containing a histaminergic H-1 receptor antagonist pharmacophore was synthesized. In vitro assays determined the compounds had both histaminergic binding and 5-lipoxygenase inhibiting activities comparable to the corresponding N-hydroxyurea analog. Animal models demonstrated antihistaminergic and the 5-lipopxygenase inhibitory activity, with the N-hydroxyurea analog having a better overall profile. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.12.023
• 作为产物：
  描述：

  1,4-二溴丁烷 、 4-碘苯酚 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 12.0h， 以89%的产率得到1-(4-溴丁氧基)-4-碘苯
  参考文献：
  名称：

  二茂铁基封端的树枝状大分子的合成，表征，电子光谱和电化学研究

  摘要：

  分别使用六倍的Sonogashira偶联反应和六倍的Huisgen环加成反应制备了两种新的十二碳二茂铁基树枝状聚合物。另外，已经通过常规合成方法合成了包含四个二茂铁基的树枝状分子。电化学研究表明，所有二茂铁单元在电化学上都是等效的。而且，当用酸处理时，这些化合物形成了具有高消光系数的多电荷的甲基化近红外吸收性树枝状染料。

  DOI：

  10.1016/j.tet.2013.03.047

文献信息

• Compounds and methods for treatment of asthma, allergy and inflammatory disorders
  申请人：UCB, S.A.

  公开号：US06451801B1

  公开（公告）日：2002-09-17

  The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl peperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferable asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obstructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.

  本发明提供了1,4取代哌嗪、1,4取代哌啶和1-取代、4-烯基哌啶化合物。本发明的化合物是具有白三烯抑制性和抗组胺性能的双重作用分子。本发明的化合物可用于治疗可能存在组胺和/或白三烯成分的疾病。这些疾病包括哮喘、季节性和全年过敏性鼻炎、鼻窦炎、结膜炎、食物过敏、曹布鱼中毒、牛皮癣、荨麻疹、瘙痒、湿疹、类风湿性关节炎、炎症性肠病、慢性阻塞性肺病、血栓性疾病和中耳炎。还提供了通过向需要的受试者施用有效的减轻哮喘和鼻炎症状的化合物的方法。
• Bioinspired zinc-mediated umpolung thiolation of alkyl electrophiles: reaction development, scope and mechanism
  作者：Yuenian Xu、Yan Zhang、Yong Liu、Wen-Wu Sun、Jie Huang、Hui He、Yingjie Wu、Wen Liu、Shao-Fei Ni、Xu-Qiong Xiao、Xinxin Shao

  DOI：10.1007/s11426-023-1795-9

  日期：2024.3

  Zinc-promoted umpolung thiolation of alkyl electrophiles with masked sulfur transfer reagents in the absence of nickel or copper catalysis is described. This protocol proceeds via a SET process of Zn to electrophilic sulfur reagent followed by insertion of Zn into disulfide and nucleophilic thiolation, providing straightforward access to a wide range of alkyl sulfides with broad substrate scope. A

  描述了在没有镍或铜催化的情况下，使用掩蔽硫转移试剂对烷基亲电子试剂进行锌促进的还原硫醇化。该方案通过Zn 与亲电硫试剂的 SET 过程进行，然后将 Zn 插入二硫化物和亲核硫醇化，从而可以直接获得具有广泛底物范围的各种烷基硫醚。合成、分离并通过 NMR、IR 和 X 射线分析充分表征了具有四面体几何形状的中性 TMEDA 连接的四配位硫醇锌。更重要的是，这种活性中间体的化学反应性已经得到研究，能够构建 C-Se、C-Te、Sb-S 和 Bi-S 键，以制备有价值的含硫分子等。
• N-(3-butyn-1-yl) N-hydroxyurea
  申请人：UCB, S.A.

  公开号：EP1418173A1

  公开（公告）日：2004-05-12

  The present invention provides a new compound N-(3-butyn-1-yl) N-hydroxyurea.

  本发明提供了一种新化合物 N-(3-丁炔-1-基) N-羟基脲。
• Evaluation of novel aryloxyalkyl derivatives of imidazole and 1,2,4-triazole as heme oxygenase-1 (HO-1) inhibitors and their antitumor properties
  作者：Loredana Salerno、Valeria Pittalà、Giuseppe Romeo、Maria N. Modica、Maria A. Siracusa、Claudia Di Giacomo、Rosaria Acquaviva、Ignazio Barbagallo、Daniele Tibullo、Valeria Sorrenti

  DOI：10.1016/j.bmc.2013.06.040

  日期：2013.9

  A novel series of aryloxyalkyl derivatives of imidazole and 1,2,4-triazole, 17-31, was designed and synthesized as inhibitors of heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2). Some of these compounds were found to be good inhibitors of HO-1, in particular those carrying an imidazole moiety as azolyl group and a 3-bromo or 4-iodophenyl as aryl moiety. The most potent compounds 6 and 30 were selected and studied for their antitumor properties in a model of LAMA-84 R cell line overexpressing HO-1 and resistant to imatinib mesylate (IM), a tyrosine-kinase inhibitor used in the treatment of multiple types of cancer, most notably Philadelphia Chromosome positive (Ph+) Chronic Myelogenous Leukemia (CML). Results show that both 6 and 30 sensitized LAMA-84 R cell line to antitumor properties of IM. (C) 2013 Elsevier Ltd. All rights reserved.
• Organic Semiconductors with Helical Structure Based on Oligothiophene derivatives Exhibiting Chiral Nematic Phase
  作者：Masahiro Funahashi、Nobuyuki Tamaoki

  DOI：10.1080/15421400701735723

  日期：2007.12.13

  We have synthesized 2-[5-(4-[(S)-2-methylbutoxy]phenyl)-3-methyl]-2'''-propyl-2: 5'-2'-5 ''-2 ''-5"'-quaterthiophene (10), a liquid crystalline semiconductor that exhibits a chiral nematic phase, and used the time-of-flight technique to determine its carrier mobility behavior. In the chiral nematic phase, the positive carrier mobility was 2 x 10(-4)cm(2)/Vs at 120 degrees C and the negative carrier mobility was 1 x 10-4 cm(2)/Vs, both of which we attribute to electronic processes. For the negative carrier, in addition to the fast electronic process, we also observed a slow carrier transport, having mobility on the order of 10(-5)cm(2)/Vs, which we attribute to ionic conduction. Chiral dimers containing binaphthyl group exhibited stable glassy cholesteric phase and cholesteric thin films with selective reflection band in visible light area could be fabricated. They emitted circularly polarized light with dichroic parameter of 1.3 when UV light was illuminated.