1-(2-aminopropoxy)propan-2-amine | 3768-47-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(2-aminopropoxy)propan-2-amine
• 英文别名: 2-Aminopropyl ether
• CAS: 3768-47-6
• 化学式: C₆H₁₆N₂O
• 分子量: 132.206
• InChiKey: FIXBBOOKVFTUMJ-UHFFFAOYSA-N

物化性质

• 沸点：
  209.1±15.0 °C(Predicted)
• 密度：
  0.930±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  61.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  二丙二醇 在 氨 、 氢气 作用下， 180.0 ℃ 、20.0 MPa 条件下， 生成 1-(2-aminopropoxy)propan-2-amine 、 Propylene glycol 2-aminopropyl ether
  参考文献：
  名称：

  Steric effects in the catalytic amination of γ-, δ-, and ε-glycols

  摘要：

  The amination of butane-1,4-diol, isomeric dipropylene glycols, and cyclohexane-1,4-diyldimethanol in the presence of nickel/copper/chromium catalysts has been studied. The effect of the initial glycol structure on the reaction selectivity has been estimated.

  DOI：

  10.1134/s1070428016120071

文献信息

• [EN] Process for the production of 2-[4-(cyclopropanecarbonyl)phenyl]-2-methyl-propanenitrile<br/>[FR] PROCÉDÉ POUR LA PRODUCTION DE 2-[4-(CYCLOPROPANECARBONYL)PHÉNYL]-2-MÉTHYL-PROPANENITRILE
  申请人：SANOFI AVENTIS DEUTSCHLAND

  公开号：WO2016116555A1

  公开（公告）日：2016-07-28

  A new process for the production of 2-[4-(cyclopropanecarbonyl)phenyl]-2-methyl- propanenitrile is described. This compound can be used for the production of drugs, such as Fexofenadine.

  描述了一种生产2-[4-(环丙基甲酰基)苯基]-2-甲基丙腈的新工艺。这种化合物可用于生产药物，如非索非丁。
• [EN] AMINE TERMINATED PREPOLYMER AND COMPOSITION COMPRISING THE SAME<br/>[FR] PRÉPOLYMÈRE À TERMINAISON AMINE ET COMPOSITION LE COMPRENANT
  申请人：SOPREMA

  公开号：WO2020239594A1

  公开（公告）日：2020-12-03

  The invention relates to an amine terminated prepolymer and to a curable composition containing this prepolymer. These compositions are used to make sealants, coatings or adhesives useful in the field of construction, public works and civil engineering.

  该发明涉及一种胺终止的预聚物，以及含有该预聚物的可固化组合物。这些组合物用于制造在建筑、公共工程和土木工程领域中有用的密封剂、涂料或粘合剂。
• BORATED BENZOXAZINE FOR USE IN THE SYNTHESIS OF POLYBENZOXAZINE
  申请人：COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN

  公开号：US20200115394A1

  公开（公告）日：2020-04-16

  A borated benzoxazine compound, which can be used in particular as monomer in the synthesis of polybenzoxazine, corresponds to the formula: in which: Z represents an at least divalent, aliphatic, cycloaliphatic or aromatic, bonding group comprising at least one carbon atom and optionally at least one heteroatom chosen from O, S and P; and R 1 , R 2 , R 3 and R 4 , which are identical or different, represent hydrogen or an alkyl comprising from 1 to 12 carbon atoms, it being possible for R 1 and R 2 , on the one hand, and R 3 and R 4 , on the other hand, optionally to form a heterocycle with the two oxygen atoms and the boron atom to which they are respectively bonded.

  一种硼酸化苯并噁嗪化合物，可用作聚苯并噁嗪合成中的单体，其化学式如下： 其中，Z表示至少二价的脂肪、环状脂肪或芳香族键合基团，包括至少一个碳原子和可选的至少一个氧、硫或磷杂原子；R1、R2、R3和R4相同或不同，表示氢或含有1至12个碳原子的烷基，R1和R2、R3和R4可选择与它们分别键合的两个氧原子和硼原子形成杂环。
• [EN] METHOD OF 4-BORONOPHENYLALANINE PRODUCTION<br/>[FR] PROCÉDÉ DE PRODUCTION DE 4-BORONOPHÉNYLALANINE
  申请人：OTSUKA PHARMA CO LTD

  公开号：WO2019163738A1

  公开（公告）日：2019-08-29

  The present invention relates to a method of production of 4-boronophenylalanine (BPA) from 4-iodophenylalanine, in which all the functional groups of the amino acid are protected by benzyl protection method, and which uses isopropyl magnesium halogenide stabilized by a complexation base, and subsequent condensation of the resulting Grignard reagent with a boric acid ester. The final reaction step, catalytic hydrogenolysis or transfer hydrogenolysis of protecting groups on the amino acid, occurs after hydrolysis of the boronate ester groups.

  本发明涉及一种从4-碘苯丙氨酸生产4-硼苯丙氨酸（BPA）的方法，其中氨基酸的所有功能基团均通过苄基保护方法进行保护，并使用由络合基稳定的异丙基镁卤化物，随后将所得的格氏试剂与硼酸酯进行缩合反应。最终的反应步骤，即氨基酸保护基的催化氢解或转移氢解，发生在硼酸酯基水解之后。
• NOVEL COMPOUNDS
  申请人：Birkett David P.

  公开号：US20100152407A1

  公开（公告）日：2010-06-17

  Ketimines, enamines and oxazolidines are moisture labile functional groups that in the presence of water undergo hydrolysis to yield free amines. Within the art such latent amines have found utility in curable compositions where it is desirable to initiate cure in the presence moisture. A number of novel polyketimines, polyenamines, polymeric oxazolidines and oxazolidines are disclosed. In particular, polymeric compounds of the above classes derived from C 6 cyclic diketones and polyamines are reported. Suitable C 6 cyclic diketones include cyclohexanediones and quinones. The invention further relates to the applications of the materials, such as in moisture cure adhesives.

  Ketimines，enamines和oxazolidines是潮解的官能团，当存在水时，它们会发生水解反应生成自由胺。在艺术领域中，这些潜在的胺在可固化组合物中发现了实用性，其中希望在存在水分的情况下启动固化。披露了许多新型的聚合物ketimines，polyenamines，聚合物oxazolidines和oxazolidines。特别是报道了从C6环状二酮和多胺衍生的上述类别的聚合物化合物。适当的C6环状二酮包括环己二酮和醌。该发明进一步涉及材料的应用，例如在潮解胶粘剂中。