3-(ethylthio)pyridine | 26891-59-8

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 3-(ethylthio)pyridine
• 英文别名: 3-ethylsulfanyl-pyridine；3-Ethylthiopyridin；3-Ethylthiopyridine；3-ethylsulfanylpyridine
• CAS: 26891-59-8
• 化学式: C₇H₉NS
• 分子量: 139.221
• InChiKey: JAGVCPHIQXGPHB-UHFFFAOYSA-N

物化性质

• 沸点：
  81 °C(Press: 0.8 Torr)
• 密度：
  1.07±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  38.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-溴吡啶 在 copper(ll) sulfate pentahydrate 、 1,2-乙二硫醇 、 potassium hydroxide 作用下， 以 水 、 二甲基亚砜 、 N,N-二甲基甲酰胺 为溶剂， 反应 25.0h， 生成 3-(ethylthio)pyridine
  参考文献：
  名称：

  铜（II）催化由芳基卤化物和1,2-乙二硫醇合成芳基硫醇

  摘要：

  利用铜（II）催化剂和1,2-乙二硫醇开发了一种高效的过渡金属催化的从芳基卤化物单步合成芳基硫醇的方法。关键特征是使用现成的试剂，简单的操作以及相对温和的反应条件。该新协议显示了广泛的底物范围，具有出色的官能团相容性。由芳基卤化物直接以高收率制备各种芳基硫醇。此外，芳基硫醇原位用于合成更高级的分子，例如二芳基硫醚和苯并噻吩。

  DOI：

  10.1002/adsc.201400941

文献信息

• 아릴 티올의 단일-단계 합성방법 및 이의 응용
  申请人：SUNGSHIN WOMEN`S UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION 성신여자대학교 연구 산학협력단(220060539816) BRN ▼209-82-08357

  公开号：KR20170076524A

  公开（公告）日：2017-07-04

  본 발명은 아릴 티올의 단일-단계 합성방법에 관한 것으로, 더욱 상세하게는 전이금속 촉매 존재 하에서 아릴 할라이드와 알칸다이티올을 반응시켜 단일-단계로 아릴 티올을 합성하는 방법에 관한 것이다. 본 발명에 따르면, 아릴 할라이드로부터 아릴 티올을 높은 수율로 합성할 수 있는, 전이 금속 촉매를 이용한 단일-단계 합성 방법을 제공할 수 있다. 상기 합성 방법에는 다양한 아릴 할라이드를 적용할 수 있다. 또한 쉽게 사용 가능한 시약을 이용할 수 있고, 조작이 간단할 뿐만 아니라, 마일드한 조건에서 반응을 수행할 수 있는 장점이 있다. 아울러 합성된 아릴 티올은 다이아릴 설파이드(diaryl sulfides), 벤조티오펜(benzothiophenes)과 같은 고급 분자(advanced molecules)의 합성에 이용될 수 있다.

  本发明涉及对芳基硫醇的单步合成方法，更详细地说，在过渡金属催化剂存在的情况下，涉及一种通过芳基卤化物和烷二硫醇在单步反应中合成芳基硫醇的方法。根据本发明，可以提供一种利用过渡金属催化剂从芳基卤化物高产率合成芳基硫醇的单步合成方法。该合成方法可以应用于各种芳基卤化物。此外，该方法具有使用方便的试剂，操作简单，且在温和条件下进行反应的优点。此外，合成的芳基硫醇可用于合成二芳基硫醚(diaryl sulfides)、苯并噻吩(benzothiophenes)等高级分子。
• CARBOSTYRIL DERIVATIVES
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP0450066A1

  公开（公告）日：1991-10-09

  This invention relates to carbostyril derivatives represented by general formula (1), a process for their preparation, and an agent for inhibiting agglutination of platelets containing them as an active ingredient, wherein A represents a lower alkylene group, R1 represents a substituted or unsubstituted cycloalkyl-lower alkyl group, a cycloalkyl group, a tetrahydropyranyl* lower alkyl group, a lower alkylenedioxy-substituted lower alkyl group, a substituted phenyl-lower alkyl group or a lower alkyl-substituted piperidinyl-lower alkyl group, R2 represents a substituted or unsubstituted 5- or 6-membered, saturated or unsaturated heterocyclic-lower alkyl group, a tetrahydropyranylthio-lower alkyl group, a pyridylthio-lower alkyl group, a lower alkylene-dioxy-substituted lower alkyl group or a substituted or unsubstituted lower alkyl group, and the carbon-to-carbon bond between the 3- position and the 4-position of the carbostyril skeleton represents either a single or a double bond.

  本发明涉及通式(1)代表的碳化二氢吡啶衍生物、其制备工艺以及含有其作为活性成分的抑制血小板凝集的制剂，其中A代表低级亚烷基，R1代表取代或未取代的环烷基-低级烷基、环烷基、四氢吡喃基*低级烷基、低级亚烷基-二氧基取代的低级烷基、取代的苯基-低级烷基或低级烷基-取代的哌啶基-低级烷基、R2 代表取代或未取代的 5 或 6 元、饱和或不饱和杂环低级烷基、四氢吡喃硫基低级烷基、吡啶硫基低级烷基、亚烷基二氧基取代的低级烷基或取代或未取代的低级烷基，碳四吡啶骨架的 3 位和 4 位之间的碳-碳键代表单键或双键。
• TREATMENT OF SOLID TUMORS
  申请人：President and Fellows of Harvard College

  公开号：EP3354265A1

  公开（公告）日：2018-08-01

  The invention relates to methods of treating protein degradation disorders, such as cellular proliferative disorders (e.g., cancer). The invention provides methods and pharmaceutical compositions for treating these diseases using aggresome inhibitors or combinations of aggresome inhibitors and proteasome inhibitors. The invention further relates to methods and pharmaceutical compositions for treating solid tumors. New HDAC/TDAC inhibitors and aggresome inhibitors are also provided as well as synthetic methodologies for preparing these compounds.

  本发明涉及治疗蛋白质降解紊乱的方法，如细胞增殖紊乱（如癌症）。本发明提供了使用侵袭酶体抑制剂或侵袭酶体抑制剂和蛋白酶体抑制剂组合治疗这些疾病的方法和药物组合物。本发明还涉及治疗实体瘤的方法和药物组合物。本发明还提供了新的HDAC/TDAC抑制剂和侵袭体抑制剂以及制备这些化合物的合成方法。
• HETEROCYCLIC COMPOUND AND HARMFUL ARTHROPOD CONTROLLING AGENT CONTAINING SAME
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP3483144A1

  公开（公告）日：2019-05-15

  The present invention provides a heterocyclic compound that exhibits superior control effect aganist harmful arthropods and that is represented by formula (I): (I) [in the formula, Q1 represents an oxygen atom or the like; Q2 represents an oxygen atom or the like; T represents a C1-C10 chain hydrocarbon group or the like; A1 represents a nitrogen atom or the like; A2 represents a nitrogen atom or the like; A3 represents a nitrogen atom or the like; A4 represents a nitrogen atom or the like; R2 represents a cyclopropyl group or the like; R3 represents a C1-C6 chain hydrocarbon groupor the like; n is 1 or 2; and q is 0, 1, 2 or 3], and also provides a composition containing said compound and one or more types of components selected from a group including a group (a), a group (b), a group (c), and a group (d) described in the Description.

  本发明提供了一种杂环化合物，该化合物对有害节肢动物具有优异的防治效果，由式(I)表示：(I) [式中，Q1 代表氧原子或类似物；Q2 代表氧原子或类似物；T 代表 C1-C10 链烃基或类似物；A1 代表氮原子或类似物；A2 代表氮原子或类似物；A3 代表氮原子或类似物；A4 代表氮原子或类似物；R2代表环丙基或类似基团；R3代表C1-C6链烃基或类似基团；n为1或2；以及q为0、1、2或3]，还提供了一种组合物，该组合物含有所述化合物和一种或多种选自包括描述中所述基团(a)、基团(b)、基团(c)和基团(d)的组的组分。
• 10.3390/molecules29112485
  作者：Nie, Jinli、He, Ziqing、Xie, Sijie、Li, Yibiao、He, Runfa、Chen, Lu、Luo, Xiai

  DOI：10.3390/molecules29112485

  日期：——

  synthesizing dialkyl or alkyl aryl thioether derivatives using odorless, stable, low-cost ROCS2K as a thiol surrogate. This transformation offers a broad substrate scope and good functional group tolerance with excellent selectivity. The reaction likely proceeds via xanthate intermediates, which can be readily generated via the nucleophilic substitution of alkyl halides or aryl halides with ROCS2K under

  硫醚在医药和有机合成领域至关重要，但大多数合成烷基硫醚的方法都采用有恶臭的硫醇作为起始原料或产生副产物。另外，大多数硫醇对空气敏感，在大气条件下很容易氧化生成二硫化物；因此，需要一种新的硫醚合成方法。本文报道了一种简单、有效、绿色的方法，使用无味、稳定、低成本的ROCS2K作为硫醇替代物合成二烷基或烷基芳基硫醚衍生物。这种转化提供了广泛的底物范围和良好的官能团耐受性以及出色的选择性。该反应可能通过黄原酸酯中间体进行，黄原酸酯中间体可以通过在无过渡金属和无碱条件下用 ROCS2K 亲核取代烷基卤或芳基卤轻松生成。