The invention encompasses compounds of Formula (I) useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3',5'-monophosphate (cAMP) through the inhibition of phosphodiesterase IV (PDE IV). The invention also encompasses certain pharmaceutical compositions and methods for treatment of diseases by inhibition of PDE IV, resulting in an elevation of cAMP, comprising the use of compounds of Formula (I).
本发明涵盖了公式(I)的化合物,通过抑制
磷酸二酯酶IV(PDE IV)提高环状
腺苷酸-3',5'-单
磷酸(c
AMP)
水平,用于治疗哮喘等疾病。本发明还涵盖了某些药物组合物和通过抑制PDE IV治疗疾病的方法,导致c
AMP升高,包括使用公式(I)的化合物。