5-{[3-(4-[3-(7-chloro-4-quinolyl)amino]propylpiperazino)propyl](cyclopropylmethyl)amino}pentanenitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5-{[3-(4-[3-(7-chloro-4-quinolyl)amino]propylpiperazino)propyl](cyclopropylmethyl)amino}pentanenitrile
• 英文别名: 5-[3-[4-[3-[(7-Chloroquinolin-4-yl)amino]propyl]piperazin-1-yl]propyl-(cyclopropylmethyl)amino]pentanenitrile
• 化学式: C₂₈H₄₁ClN₆
• 分子量: 497.127
• InChiKey: WQHUJEOBBVFEBT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  35
• 可旋转键数：
  15
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  58.4
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  5-氯戊腈 、 N4-[3-(4-{3-[(cyclopropylmethyl)amino]propyl}piperazino)propyl]-7-chloroquinolin-4-amine 在 N-乙基哌啶 作用下， 以 乙腈 为溶剂， 反应 6.0h， 以42%的产率得到5-{[3-(4-[3-(7-chloro-4-quinolyl)amino]propylpiperazino)propyl](cyclopropylmethyl)amino}pentanenitrile
  参考文献：
  名称：

  Synthesis and antimalarial evaluation of new N1-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine derivatives

  摘要：

  Synthesis and evaluation of the activity of new N-1-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine derivatives against a chloroquine-resistant strain of Plasmodium falciparum are described. Selectivity indices were improved for two compounds versus the lead 1, the bis-cyclopropylmethyl derivative, thus increasing the therapeutic interest of our family. As our previous studies conducted on the mode of action of our compounds made us hypothesize the existence of original mechanisms and/or original targets, terminal amino derivatives can be considered as promising tools further mechanistical studies, as probes for affinity chromatography. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.10.080

文献信息

• Use of 1,4-bis (3-aminoalkyl) piperazine derivatives in the treatment of neurodegenerative diseases
  申请人：Sergeant Nicolas

  公开号：US20090149464A1

  公开（公告）日：2009-06-11

  Use of 1,4-bis(3-aminoalkyl)piperazine derivatives as defined in formula I or II for the manufacture of a pharmaceutical composition intended for the treatment of neurodegenerative diseases, related neurodegenerative diseases, developmental diseases or cancer. The instant invention is also directed to some specific 1,4-bis(3-aminoalkyl)piperazine derivatives and pharmaceutical composition including them.

  使用公式I或II中定义的1,4-双(3-氨基烷基)哌嗪衍生物制造用于治疗神经退行性疾病、相关神经退行性疾病、发育性疾病或癌症的药物组合物。本发明还涉及一些特定的1,4-双(3-氨基烷基)哌嗪衍生物和包括它们的药物组合物。
• WO2006/51489
  申请人：——

  公开号：——

  公开（公告）日：——
• USE OF 1,4-BIS (3-AMINOALKYL) PIPERAZINE DERIVATIVES IN THE TREATMENT OF NEURODEGENERATIVE DISEASES
  申请人：INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

  公开号：EP1809288B1

  公开（公告）日：2011-09-14
• US9044478B2
  申请人：——

  公开号：US9044478B2

  公开（公告）日：2015-06-02
• [EN] USE OF 1,4-BIS (3-AMINOALKYL) PIPERAZINE DERIVATIVES IN THE TREATMENT OF NEURODEGENERATIVE DISEASES<br/>[FR] UTILISATION DE DERIVES DE LA 1,4-BIS (3-AMINOALKYL) PIPERAZINE POUR LE TRAITEMENT DE MALADIES NEURODEGENERATIVES
  申请人：EDICALE INSERM INST NAT DE LA

  公开号：WO2006051489A1

  公开（公告）日：2006-05-18

  [EN] Use of 1,4-bis (3-aminoalkyl) piperazine derivatives as defined in formula I or II for the manufacture of a pharmaceutical composition intended for the treatment of neurodegenerative diseases, related neurodegenerative diseases, developmental diseases or cancer. The instant invention is also directed to some specific 1,4-bis (3-aminoalkyl) piperazine derivatives and pharmaceutical composition including them.
  [FR] L'invention porte sur l'utilisation de dérivés de la 1,4-bis (3-aminoalkyl) pipérazine de formule (I) et (II) pour la fabrication de préparations pharmaceutiques devant servir au traitement de maladies neurodégénératives et de maladies associées, de troubles du développement et du cancer. L'invention porte également sur certains dérivés spécifiques de la 1,4-bis (3-aminoalkyl) pipérazine et sur des préparations pharmaceutiques les contenant.