2-dodecynoic acid | 67587-18-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-dodecynoic acid
• 英文别名: dodec-2-ynoic acid；Undecin-(1)-carbonsaeure-(1)；n-Nonylpropiolsaeure；Dodec-2-insaeure
• CAS: 67587-18-2
• 化学式: C₁₂H₂₀O₂
• 分子量: 196.29
• InChiKey: YJDGZMNYNLBUNV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-dodecynoic acid 在 氢氧化钾 作用下， 生成 2-十一酮
  参考文献：
  名称：

  Moureu; Delange, Bulletin de la Societe Chimique de France, 1903, vol. <3>29, p. 674

  摘要：

  DOI：
• 作为产物：
  描述：

  1-十一炔 在 lithium hydroxide 、 正丁基锂 作用下， 以 四氢呋喃 、 甲醇 、 正己烷 为溶剂， 反应 13.0h， 生成 2-dodecynoic acid
  参考文献：
  名称：

  Structure-antitumor Activity Relationship of Semi-synthetic Spicamycin Derivatives.

  摘要：

  新合成了一系列在分子脂肪酸部分进行了修饰的斯匹卡霉素衍生物，并研究了它们的构效关系。通过对脂肪酸部分进行修饰，将其转化为十四碳二烯酸或十二碳二烯酸类似物，这些衍生物对COL-1人结肠癌异种移植模型的抗肿瘤活性显著优于SPM VIII。

  DOI：

  10.7164/antibiotics.48.1467

文献信息

• Total Synthesis of Luminmycin A, a Cryptic Natural Product from <i>Photorhabdus Luminescens</i>
  作者：Phil Servatius、Tanja Stach、Uli Kazmaier

  DOI：10.1002/ejoc.201900460

  日期：2019.6.2

  Luminmycin A, a natural proteasome inhibitor has been synthesized for the first time. Key steps are an intramolecular Horner–Wadsworth–Emmons reaction and a PPh3‐catalyzed isomerization of a acetylenic fatty acid ester, giving access to the double unsaturated fatty acid side chain.

  首次合成了天然蛋白酶体抑制剂LuminmycinA。关键步骤是分子内霍纳-沃兹沃思-埃蒙斯反应和炔属脂肪酸酯的PPh 3催化异构化，从而可以进入双不饱和脂肪酸侧链。
• COMPOSITION FOR PROTECTION OF BODY SURFACE
  申请人：Asahi Kasei Chemicals Corporation

  公开号：EP1891924A1

  公开（公告）日：2008-02-27

  A body surface protecting composition, comprising at least one type of multi-chain multiple hydrophilic group-type compound having two or more hydrophobic groups and two or more hydrophilic groups in the molecule, which has an excellent effect of accelerating the recovery of the barrier function of skin and hair and preventing degradation of that function.

  一种体表保护组合物，包含至少一种多链多亲水基团型化合物，其分子中含有两个或两个以上的疏水基团和两个或两个以上的亲水基团，该组合物在加速恢复皮肤和头发的屏障功能以及防止该功能退化方面具有极佳的效果。
• DISPERSION LIQUID AND HYDROGEL FORMATION METHOD
  申请人：Nissan Chemical Industries, Ltd.

  公开号：EP2865442A1

  公开（公告）日：2015-04-29

  There is provided a dispersion containing a lipid peptide type compound useful as a low molecular weight gelator, such as a lipid dipeptide and a lipid tripeptide, and a solvent capable of dissolving the lipid peptide type compound at a lower temperature more easily. There is provided also a dispersion from which a hydrogel can be formed by a simpler method and under a milder condition (low temperature) and from which a gel can be obtained as a gel having high thermal stability, and provide a method for forming the gel. A dispersion comprising a lipid peptide type compound in which a peptide portion having an amino acid repeating bonding structure is bonded to a lipid portion consisting of a C9-23 aliphatic group; and at least one alcohol selected from the group consisting of 1,2-alkanediol, 1,3-alkanediol, and ethylene glycol monoalkyl ether or a mixed solution of the at least one alcohol and water; and a method for producing a hydrogel by use of the dispersion.

  本发明提供了一种含有可用作低分子量凝胶剂的脂质肽类化合物（如脂质二肽和脂质三肽）的分散液，以及一种能够在较低温度下更容易溶解脂质肽类化合物的溶剂。本发明还提供了一种分散液，可通过更简单的方法在更温和的条件下（低温）形成水凝胶，并从中获得具有高热稳定性的凝胶，同时还提供了形成凝胶的方法。一种包含脂肽型化合物的分散液，其中具有氨基酸重复键合结构的肽部分与由 C9-23 脂肪族基团组成的脂质部分键合；以及至少一种选自 1,2-烷二醇、1,3-烷二醇和乙二醇单烷基醚或至少一种醇和水的混合溶液组成的组的醇，以及一种通过使用该分散液生产水凝胶的方法。
• DISPERSION AND METHOD FOR FORMING HYDROGEL
  申请人：NISSAN CHEMICAL INDUSTRIES, LTD.

  公开号：EP3296013A1

  公开（公告）日：2018-03-21

  There is provided a dispersion containing a lipid peptide type compound useful as a low molecular weight gelator, such as a lipid dipeptide and a lipid tripeptide, and a solvent capable of dissolving the lipid peptide type compound at a lower temperature more easily. There is provided also a dispersion from which a hydrogel can be formed by a simpler method and under a milder condition (low temperature) and from which a gel can be obtained as a gel having high thermal stability, and provide a method for forming the gel. A dispersion comprising a lipid peptide type compound in which a peptide portion having an amino acid repeating bonding structure is bonded to a lipid portion consisting of a C9-23 aliphatic group; and at least one alcohol selected from the group consisting of 1,2-alkanediol, 1,3-alkanediol, and ethylene glycol monoalkyl ether or a mixed solution of the at least one alcohol and water; and a method for producing a hydrogel by use of the dispersion.

  本发明提供了一种含有可用作低分子量凝胶剂的脂质肽类化合物（如脂质二肽和脂质三肽）的分散液，以及一种能够在较低温度下更容易溶解脂质肽类化合物的溶剂。本发明还提供了一种分散液，可通过更简单的方法在更温和的条件下（低温）形成水凝胶，并从中获得具有高热稳定性的凝胶，同时还提供了形成凝胶的方法。一种包含脂肽型化合物的分散液，其中具有氨基酸重复键合结构的肽部分与由 C9-23 脂肪族基团组成的脂质部分键合；以及至少一种选自 1,2-烷二醇、1,3-烷二醇和乙二醇单烷基醚或至少一种醇和水的混合溶液组成的组的醇，以及一种通过使用该分散液生产水凝胶的方法。
• COSMETIC COMPOSITION
  申请人：Rohto Pharmaceutical Co., Ltd.

  公开号：EP3616683A1

  公开（公告）日：2020-03-04

  Provided is a cosmetic composition that maintains high stability and restrains from becoming cloud. This cosmetic composition is prepared by including (A) polyoxyethylene polyoxypropylene glycol, and (B) an amino acid based surfactant having, in a single molecule thereof, two or more hydrophobic groups and two or more hydrophilic groups. Furthermore, provided is a method of giving a cloudiness-restraining effect to a cosmetic composition, including causing the component (A) and the component (B) to coexist with each other in the cosmetic composition.

  本发明提供了一种化妆品组合物，它能保持高稳定性并防止变浊。 这种化妆品组合物的制备方法是：(A) 聚氧乙烯聚氧丙烯二醇；(B) 氨基酸基表面活性剂，在其单个分子中具有两个或两个以上的疏水基团和两个或两个以上的亲水基团。此外，还提供了一种使化妆品组合物具有抑浊效果的方法，包括使组分（A）和组分（B）在化妆品组合物中共存。