Synthesis of Quinolines via Rh(III)-Catalyzed Oxidative Annulation of Pyridines
作者:Guoyong Song、Xue Gong、Xingwei Li
DOI:10.1021/jo201266u
日期:2011.9.16
Selective synthesis of quinolines has been achieved via oxidative annulation of functionalized pyridines with two alkyne molecules under Rh(III)-catalyzed cascade C–H activation of pyridines using Cu(OAc)2 as an oxidant. The selectivity of this reaction is oxidant-dependent, particularly on the anion of the oxidant.
Using <sup>2</sup>
H labelling to improve the NMR detectability of pyridine and its derivatives by SABRE
作者:Philip Norcott、Michael J. Burns、Peter J. Rayner、Ryan E. Mewis、Simon B. Duckett
DOI:10.1002/mrc.4703
日期:2018.7
By introducing a range of 2 H labels into pyridine and the para-substituted agents, methyl isonicotinate and isonicotinamide, we significantly improve their NMR detectability in conjunction with the signal amplification by reversible exchange process. We describe how the rates of T1 relaxation for the remaining 1 H nuclei are increased and show how this leads to a concomitant increase in the level