Menthyl 1,4-disubstituted 1,2,3-triazole derivatives of hydroxybenzaldehydes, phenols and bile acids were synthesized via click chemistry. The novel synthesized compounds were evaluated for their in vitro antibacterial activity against Enterococcus faecium, and Staphylococcus aureus as Gram-positive bacteria. Some derivatives illustrated strong inhibitory effect against E. faecium with the minimum inhibitory concentration (MIC) values ranged from 1–3 µM, where cefixime as a positive control revealed MIC value of 35 µM. The structures of the synthesized compounds were confirmed by different spectroscopic techniques including 1H-NMR, 13C-NMR, high resolution (HR)-MS, IR and X-ray crystallographic analysis.
通过点击
化学方法合成了羟基
苯甲醛、
酚类和
胆酸的甲基1,4-二取代
1,2,3-三氮唑衍
生物。对这些新型合成化合物进行了体外抗菌活性评估,针对革兰氏阳性菌屎肠球菌和
金黄色葡萄球菌。某些衍
生物对肠球菌表现出强烈的抑制作用,最低抑制浓度(MIC)值在1-3 µM范围内,而作为阳性对照的头孢克
肟显示MIC值为35 µM。通过包括1H-NMR、13C-NMR、高分辨率(HR)-MS、IR和X射线晶体学分析在内的不同光谱技术确认了合成化合物的结构。