1-(4'-甲氧基-2-硝基-[1,1'-联苯]-4-基)乙酮 | 52806-71-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1-(4'-甲氧基-2-硝基-[1,1'-联苯]-4-基)乙酮
• 英文名称: 4-Acetyl-4'-methoxy-2-nitro biphenyl
• 英文别名: 1-(4'-Methoxy-2-nitro-[1,1'-biphenyl]-4-yl)ethanone；1-[4-(4-methoxyphenyl)-3-nitrophenyl]ethanone
• CAS: 52806-71-0
• 化学式: C₁₅H₁₃NO₄
• 分子量: 271.273
• InChiKey: WHZFSKAALFOMFN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  72.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(4'-甲氧基-2-硝基-[1,1'-联苯]-4-基)乙酮 在 盐酸 、 potassium carbonate 、 tin(ll) chloride 作用下， 生成 2-(2,4'-Dimethoxy-4-biphenylyl)-propionsaeure
  参考文献：
  名称：

  DE2329125

  摘要：

  公开号：
• 作为产物：
  描述：

  4-碘苯甲醚 、 4-溴-3-硝基苯乙酮 在 铜 作用下， 生成 1-(4'-甲氧基-2-硝基-[1,1'-联苯]-4-基)乙酮
  参考文献：
  名称：

  DE2329125

  摘要：

  公开号：

文献信息

• Phenylalkanoic acids
  申请人：The Boots Company Limited

  公开号：US03969402A1

  公开（公告）日：1976-07-13

  New compounds are described that are 2-(hydroxy substituted-4-biphenylyl)propionic acids. Processes of making and using them and pharmaceutical compositions containing them are also described. The compounds have, inter alia, antiinflammatory activity.

  描述了一种新的化合物，即2-(羟基取代的4-联苯基)丙酸。还描述了制备和使用它们以及含有它们的药物组合物的过程。这些化合物具有抗炎活性等特性。
• Substituted benzoylbenzene-, biphenyl- and 2-oxazole-alkanoic acid
  申请人：American Home Products Corporation

  公开号：US05071988A1

  公开（公告）日：1991-12-10

  There are disclosed compounds of the formula A(CH.sub.2).sub.n O--B wherein A is ##STR1## n is 1-2; B is ##STR2## wherein R.sup.4 and R.sup.5 are each, independently, hydrogen or lower alkyl; R.sup.6 is hydrogen, halo or nitro; ##STR3## R.sup.8 is lower alkyl; m is 0-3; and the pharmacologically acceptable salts thereof, and their use in the treatment of inflammatory conditions, such as rheumatoid arthritis, ulcerative colitis, psoriasis and other immediate hypersensitivity reactions; in the treatment of leukotriene-mediated nasobronchial obstructive air-passageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like; and as gastric cytoprotective agents.

  已公开化合物的化学式为A(CH2)nO-B，其中A为##STR1## n为1-2；B为##STR2##其中R4和R5各自独立地为氢或较低的烷基；R6为氢、卤素或硝基；##STR3## R8为较低的烷基；m为0-3；以及其药理学上可接受的盐，以及它们在治疗炎症性疾病（如风湿性关节炎、溃疡性结肠炎、牛皮癣和其他即时超敏反应）中的用途；在治疗白三烯介导的鼻支气管阻塞性疾病（如过敏性鼻炎、过敏性支气管哮喘等）中的用途；以及作为胃黏膜保护剂。
• Method and composition for treating neurodegenerative disorders
  申请人：Hobden Adrian

  公开号：US20050288375A1

  公开（公告）日：2005-12-29

  The invention provides compositions and methods for treating neurodegenerative disorders. A method of the invention involves administering to an individual in need of treatment a composition having an R-NSAID and an NMDA antagonist. Another method of the invention involves administering to an individual in need of treatment a composition having at least two compounds that are capable of interacting with CYP2C9, wherein at least one of said compounds is an Aβ 42 lowering agent. The methods and compositions of the invention are useful for treating and preventing neurodegenerative disorders like Alzheimer's disease, dementia, mild cognitive impairment.

  本发明提供了用于治疗神经退行性疾病的组合物和方法。该发明的一种方法涉及向需要治疗的个体施用具有R-NSAID和NMDA拮抗剂的组合物。该发明的另一种方法涉及向需要治疗的个体施用至少两种能够与CYP2C9相互作用的化合物的组合物，其中至少一种化合物是Aβ42降低剂。该发明的方法和组合物对于治疗和预防像阿尔茨海默病、痴呆症、轻度认知障碍等神经退行性疾病非常有用。
• Substituted benzoylbenzene-, biphenyl- and 2-oxazole- alkanoic acid
  申请人：American Home Products Corporation

  公开号：US05364944A1

  公开（公告）日：1994-11-15

  There are disclosed substituted benzoylbenzene-, biphenyl- and 2-oxazole- alkanoic acid derivatives and the pharmacologically acceptable salts thereof as inhibitors of PLA.sub.2 and lipoxygenase, and their use in the treatment of inflammatory conditions, such as rheumatoid arthritis, ulcerative colitis, psoriasis and other immediate hypersensitivity reactions; in the treatment of leukotriene-mediated naso-bronchial obstructive air-passageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like; and as gastric cytoprotective agents.

  本发明涉及取代苯甲酰苯、联苯和2-噁唑-烷基酸衍生物及其药理学上可接受的盐，作为PLA.sub.2和脂氧合酶的抑制剂，并用于治疗炎症疾病，如风湿性关节炎、溃疡性结肠炎、银屑病和其他即时超敏反应；用于治疗白三烯介导的鼻支气管阻塞性通气道疾病，如过敏性鼻炎、过敏性支气管哮喘等；以及作为胃黏膜保护剂。
• SUBSTITUTED BENZOYLBENZENE-, BIPHENYL- AND 2-OXAZOLE- ALKANOIC ACID DERIVATIVES AS INHIBITORS OF PLA 2? AND LIPOXYGENASE
  申请人：AMERICAN HOME PRODUCTS CORPORATION

  公开号：EP0497888A1

  公开（公告）日：1992-08-12