双(戊氧基)甲烷 | 16849-82-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 双(戊氧基)甲烷
• 英文名称: bis(pentyloxy)methane
• 英文别名: dipentoxymethane；bis-pentyloxy-methane；formaldehyde dipentylacetal；Formaldehyd-dipentylacetal；Bis-pentyloxy-methan；Dipentylformal；1-(pentoxymethoxy)pentane
• CAS: 16849-82-4
• 化学式: C₁₁H₂₄O₂
• 分子量: 188.31
• InChiKey: HOHHGINUXNVGIT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  13
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  双(戊氧基)甲烷 在 zinc(II) chloride 、 三氯化磷 作用下， 反应 12.0h， 以40%的产率得到<(pentyloxy)methyl>phosphonic dichloride
  参考文献：
  名称：

  Petrov, K. A.; Chauzov, V. A.; Agafonov, S. V., Journal of general chemistry of the USSR, 1980, vol. 50, # 4, p. 628 - 633

  摘要：

  DOI：
• 作为产物：
  描述：

  戊醇 、 1-Tetradecyloxymethylpyridinium-chlorid 生成 双(戊氧基)甲烷
  参考文献：
  名称：

  Causes of employee theft and strategies that HR managers can use for prevention

  摘要：

  DOI：

  10.1002/(sici)1099-050x(200021)39:1<51::aid-hrm5>3.0.co;2-5

文献信息

• Dimethyl sulfoxide as a “methylene” source: Ru(<scp>ii</scp>) photo-catalysed facile synthesis of acetals from alcohols
  作者：Ranadeep Talukdar

  DOI：10.1039/c9nj03422f

  日期：——

  Acetals are important molecules with versatile reactivity and uses. For the first time a simple photo-catalysed facile synthesis of formaldehyde acetals is documented herein upon the reaction of alcohols with dimethyl sulfoxide under very mild conditions in the presence of air. The reactions require only 1 mol% of RuII(bpy)3Cl2 photocatalyst under blue LED irradiation (λ = 445 nm) to give good to excellent

  缩醛是具有通用反应性和用途的重要分子。本文首次报道了醇与二甲基亚砜在非常温和的条件下在空气存在下反应后，甲醛缩醛的简单光催化简便合成。在蓝色LED辐射（λ = 445 nm）下，该反应仅需要1 mol％的Ru II（bpy）3 Cl 2光催化剂，以得到相应的乙缩醛产物良好的优异产率。此处，DMSO充当“亚甲基”来源。
• PROCESS FOR PREPARING AN ALKOXYMETHYL ALKYNYL ETHER COMPOUND HAVING A TERMINAL TRIPLE BOND
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：US20210198172A1

  公开（公告）日：2021-07-01

  The present invention provides a process for preparing an alkoxymethyl alkynyl ether compound having a terminal triple bond of the following formula (4): H—C≡C(CH 2 ) a OCH 2 OCH 2 R (4), wherein R represents a hydrogen atom, an n-alkyl group having 1 to 9 carbon atoms, or a phenyl group, and “a” represents an integer of 1 to 10, the method comprising subjecting an alkynol compound having a terminal triple bond of the following formula (1): H—C≡C(CH 2 ) a OH (1), wherein “a” is as defined above, to an alkoxymethylation with a halomethyl alkyl ether compound of the following formula (3): RCH 2 OCH 2 X (3), wherein X represents a halogen atom, and R is as defined above, in the presence of a dialkylaniline compound of the following formula (2): [CH 3 (CH 2 ) b ][CH 3 (CH 2 ) c ]NC 6 H 5 (2), wherein b and c represent, independently of each other, an integer of 0 to 9, to form the alkoxymethyl alkynyl ether compound (4) having a terminal triple bond.

  本发明提供了一种制备具有以下式(4)的末端三键的烷氧甲基炔基醚化合物的方法：H—C≡C(CH2)aOCH2OCH2R (4)，其中R代表氢原子、具有1至9个碳原子的n-烷基基团或苯基，而“a”代表1至10的整数，所述方法包括将具有以下式(1)末端三键的炔醇化合物进行烷氧甲基化，其中H—C≡C(CH2)aOH (1)，其中“a”如上所定义，与具有以下式(3)的卤甲基烷醚化合物进行反应：RCH2OCH2X (3)，其中X代表卤素原子，R如上所定义，在存在以下式(2)的二烷基苯胺化合物的情况下进行，[CH3(CH2)b][CH3(CH2)c]NC6H5(2)，其中b和c独立地代表0至9的整数，以形成具有末端三键的烷氧甲基炔基醚化合物(4)。
• N-Substituted Carbamic Acid Ester Production Method, Isocyanate Production Method Using Such N-Substituted Carbamic Acid Ester, And Composition For Transfer And Storage Of N-Substituted Carbamic Acid Ester Comprising N-Substituted Carbamic Acid Ester and Aromatic Hydroxy Compound
  申请人：Shinohata Masaaki

  公开号：US20110133121A1

  公开（公告）日：2011-06-09

  The present invention is a method for producing an N-substituted carbamic acid ester derived from an organic amine from an organic amine, a carbonic acid derivative and a hydroxy composition containing one or more types of hydroxy compounds, wherein the organic amine, the carbonic acid derivative and the hydroxy composition are reacted using a urethane production reaction vessel provided with a condenser, a gas containing the hydroxy composition, the compound having the carbonyl group derived from the carbonic acid derivative, and an ammonia formed as a by-product in the reaction, is introduced into the condenser provided in the urethane production reaction vessel, and the hydroxy composition and the compound having the carbonyl group derived from the carbonic acid derivative are condensed, and wherein a stoichiometric ratio of a hydroxy compound contained in the condensed hydroxy composition to the condensed compound having the carbonyl group derived from the carbonic acid derivative is 1 or more, and a ratio of number of carbonyl groups (—C(═O)—) contained in the compound having the carbonyl group derived from the carbonic acid derivative and number of ammonia molecules contained in the ammonia recovered as a gas from the condenser is 1 or less.

  本发明涉及一种从有机胺、碳酸衍生物和含有一种或多种羟基化合物中制得的N-取代氨基甲酸酯的制备方法，其中使用一种含有冷凝器的脲类生产反应容器反应有机胺、碳酸衍生物和羟基化合物，将含有羟基化合物的气体、来自碳酸衍生物衍生的含有羰基基团的化合物、以及在反应中形成的氨气体引入到脲类生产反应容器中的冷凝器中，使羟基化合物和含有羰基基团的化合物冷凝，其中在冷凝的羟基化合物中所含有的羟基化合物与冷凝的含有羰基基团的化合物中所含有的羰基基团的化合物的比例为1或更多，而且在从冷凝器中回收的氨气体中所含有的羰基基团（—C(═O)—）数与氨分子数的比例为1或更少。
• N-Substituted Carbamic Acid Ester Production Method, Isocyanate Production Method Using Such N-Substituted Carbamic Acid Ester, and Composition for Transfer and Storage of N-Substituted Carbamic Acid Ester Comprising N-Substituted Carbamic Acid Ester and Aromatic Hydroxy Compound
  申请人：Asahi Kasei Chemicals Corporation

  公开号：US20140194650A1

  公开（公告）日：2014-07-10

  The present invention is a method for producing an N-substituted carbamic acid ester derived from an organic amine from an organic amine, a carbonic acid derivative and a hydroxy composition containing one or more types of hydroxy compounds, wherein the organic amine, the carbonic acid derivative and the hydroxy composition are reacted using a urethane production reaction vessel provided with a condenser, a gas containing the hydroxy composition, the compound having the carbonyl group derived from the carbonic acid derivative, and an ammonia formed as a by-product in the reaction, is introduced into the condenser provided in the urethane production reaction vessel, and the hydroxy composition and the compound having the carbonyl group derived from the carbonic acid derivative are condensed, and wherein a stoichiometric ratio of a hydroxy compound contained in the condensed hydroxy composition to the condensed compound having the carbonyl group derived from the carbonic acid derivative is 1 or more, and a ratio of number of carbonyl groups (—C(═O)—) contained in the compound having the carbonyl group derived from the carbonic acid derivative and number of ammonia molecules contained in the ammonia recovered as a gas from the condenser is 1 or less.

  本发明是一种从有机胺、碳酸酯衍生物和含有一种或多种羟基化合物中制备N-取代的氨基甲酸酯的方法，其中利用一种尿素生产反应容器反应有机胺、碳酸酯衍生物和羟基化合物，该反应容器配有冷凝器，将含有羟基化合物的气体、由碳酸酯衍生物产生的含有羰基基团的化合物以及在反应中生成的氨引入到尿素生产反应容器中的冷凝器中，将羟基化合物和含有羰基基团的碳酸酯衍生物冷凝，其中在冷凝的羟基化合物中所含的羟基化合物的化学计量比与所冷凝的含有羰基基团的化合物的化学计量比为1或更多，而且所含有羰基基团的化合物中所含的羰基基团（-C(═O)-）的数量与从冷凝器中回收的氨分子数量的比率为1或更小。
• Substituted N-methylene derivatives of thienamycin sulfoxide and sulfone and their preparation
  申请人：Merck & Co., Inc.

  公开号：EP0001264A1

  公开（公告）日：1979-04-04

  Disclosed are substituted N-methylene derivatives of thienamycin sulfoxide (1, n=1) and sulfone (I, n=2) which may be represented by the following structural formula: wherein X and Y are selected from the group consisting of hydrogen, R, OR, SR, and NR' R2 wherein, inter alia, R is substituted or unsubstituted: alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heterocyclyl, and heterocyclylalkyl; R1 and R2 are hydrogen or R. Such compounds and their pharmaceutically acceptable salt, ether, ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.

  本发明公开了噻喃霉素亚砜（1，n=1）和砜（I，n=2）的取代 N-亚甲基衍生物，其结构式如下： 其中 X 和 Y 选自由氢、R、OR、SR 和 NR' R2 组成的组，其中除其他外，R 是取代或未取代的：烷基、烯基、炔基、环烷基、环烷基烷基、芳基、芳烷基、杂芳基、杂芳基烷基、杂环烷基和杂环烷基；R1 和 R2 是氢或 R。此类化合物及其药学上可接受的盐、醚、酯和酰胺衍生物可用作抗生素。此外，还公开了制备此类化合物的工艺；包含此类化合物的药物组合物；以及治疗方法，包括在需要抗生素效果时施用此类化合物和组合物。