1,1-dimethoxy-pentan-2-ol | 53662-58-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,1-dimethoxy-pentan-2-ol
• 英文别名: 1,1-Dimethoxypentan-2-ol
• CAS: 53662-58-1
• 化学式: C₇H₁₆O₃
• 分子量: 148.202
• InChiKey: GJPPZMAEWBSHDE-UHFFFAOYSA-N

物化性质

• 沸点：
  62 °C(Press: 23 Torr)
• 密度：
  0.955±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,1-dimethoxy-pentan-2-ol 在 PPA 、 Polyphosphoric acid (PPA) 、 四氯化钛 、 potassium carbonate 作用下， 反应 1.33h， 生成 3-Propyl-indole-1-carboxylic acid methyl ester
  参考文献：
  名称：

  Shono, Tatsuya; Matsumura, Yoshihiro; Inoue, Kenji, Journal of the Chemical Society. Perkin transactions I, 1986, p. 73 - 78

  摘要：

  DOI：
• 作为产物：
  描述：

  2-溴戊醛 、 sodium methylate 以 甲醇 为溶剂， 生成 1,1-dimethoxy-pentan-2-ol
  参考文献：
  名称：

  Kraus,J.-L.; Sturtz,G., Bulletin de la Societe Chimique de France, 1974, p. 943 - 952

  摘要：

  DOI：

文献信息

• Substrate specificity and carbohydrate synthesis using transketolase
  作者：Yoshihiro Kobori、David C. Myles、George M. Whitesides

  DOI：10.1021/jo00048a023

  日期：1992.10

  This paper describes the use of the enzyme transketolase as a catalyst in organic synthesis. The properties of transketolase from both yeast and spinach were investigated. The yeast enzyme was found to be more convenient for routine use. Examination of the substrate specificity of yeast transketolase demonstrated that the enzyme accepts a wide variety of 2-hydroxy aldehydes as substrates. A practical protocol for transketolase-catalyzed condensation of hydroxypyruvic acid with these aldehydes has been developed and used for the synthesis of four carbohydrates: L-idose, L-gulose, 2-deoxy-L-xylohexose, and L-xylose.
• Diastereoselectivity (enantioselectivity) of aldol condensations catalyzed by rabbit muscle aldolase at C-2 of RCHOHCHO if R has an appropriately placed negatively charged group
  作者：Watson J. Lees、George M. Whitesides

  DOI：10.1021/jo00059a047

  日期：1993.3

  D-Fructose 1,6-bis(phosphate) aldolase from rabbit muscle (RAMA, E.C. 4.1.2.13) catalyzes the aldol condensation between dihydroxyacetone phosphate (DHAP) and various aldehydes; the products are ketosugars with 3(S),4(R) stereochemistry. When racemic alpha-hydroxy aldehydes are condensed with DHAP, two diastereomeric products are formed. This paper demonstrates that RAMA can kinetically resolve alpha-hydroxy aldehydes with a negative charge removed four or five atoms from the aldehydic center. Kinetic resolution of either uncharged alpha-hydroxy aldehydes, or of alpha-hydroxy aldehydes with a negative charge removed three or seven atoms from the aldehydic carbon, is generally not as successful.
• SHONO, TATSUYA;MATSUMURA, YOSHIHIRO;INOUE, KENJI;IWASAKI, FUMIAKI, J. CHEM. SOC. PERKIN TRANS., 1986, N 1, 73-77
  作者：SHONO, TATSUYA、MATSUMURA, YOSHIHIRO、INOUE, KENJI、IWASAKI, FUMIAKI

  DOI：——

  日期：——