2,4,6-Trichlor-phenacylbromid | 56719-70-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,4,6-Trichlor-phenacylbromid
• 英文别名: 2-Bromo-1-(2,4,6-trichlorophenyl)ethan-1-one；2-bromo-2',4',6'-trichloroacetophenone；2-bromo-1-(2,4,6-trichloro-phenyl)-ethanone；2-Brom-1-(2,4,6-trichlor-phenyl)-aethanon；2-Bromo-1-(2,4,6-trichlorophenyl)ethanone
• CAS: 56719-70-1
• 化学式: C₈H₄BrCl₃O
• 分子量: 302.382
• InChiKey: NDRNGEZMYNKZQY-UHFFFAOYSA-N

物化性质

• 熔点：
  81 °C
• 沸点：
  303.6±37.0 °C(Predicted)
• 密度：
  1.778±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,4,6-Trichlor-phenacylbromid 在 formamide 作用下， 生成 4-(2,4,6-trichlorobenzoyl)imidazole
  参考文献：
  名称：

  Cyanoimidazole fungicides

  摘要：

  这项发明提供了式I中的化合物，其中X、R¹、R²和R³如描述中所定义。这些化合物具有有价值的杀真菌活性。

  公开号：

  EP0284277A1
• 作为产物：
  描述：

  1-(2,4,6-三氯苯基)乙酮 以94%的产率得到2,4,6-Trichlor-phenacylbromid
  参考文献：
  名称：

  4-Aminothiazole derivatives, their preparation and their use as inhibitors of cyclin-dependent kinases

  摘要：

  公开号：

  EP1215208B1

文献信息

• [EN] BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES USEFUL IN THE TREATMENT OF HYPER-PROLIFERATIVE DISORDERS<br/>[FR] DERIVES DE BENZOFURANE ET DE BENZOTHIOPHENE UTILISES DANS LE TRAITEMENT DE TROUBLES HYPERPROLIFERATIFS
  申请人：BAYER PHARMACEUTICALS CORP

  公开号：WO2003072561A1

  公开（公告）日：2003-09-04

  This invention relates to novel benzofuran and benzothiophene derivatives of the general formula and their use for the treatment of hyper-proliferative disorders.

  这项发明涉及一般式的新型苯并呋喃和苯并噻吩衍生物及其用于治疗高增殖性疾病的用途。
• Facile synthesis of indolizines using layered double hydroxides@poly( <i>p</i> ‐phenylenediamine) as a catalyst with a green tool (neat technology)
  作者：Zahra Karamshahi、Ramin Ghorbani‐Vaghei

  DOI：10.1002/aoc.5347

  日期：2020.3

  phenacyl bromide, dimethyl acetylenedicarboxylate and pyridine is catalyzed by layered double hydroxides@poly(p‐phenylenediamine) (LDHs@PpPDA), in a one‐pot reaction, in order to give the corresponding indolizines in excellent yields.

  苯甲酰溴，乙炔二羧酸二甲酯和吡啶的三组分反应是通过单反应锅中的层状双氢氧化物@聚对苯二胺（LDHs @ PpPDA）催化的，以便以优异的收率得到相应的吲哚嗪。
• Imidazable fungicides and use thereof
  申请人：Schering Agrochemicals Ltd.

  公开号：US05045557A1

  公开（公告）日：1991-09-03

  The invention provides compounds of formula I ##STR1## in which X, R.sup.1, R.sup.2 and R.sup.3 are as defined in the description. The compounds have valuable fungicidal activity.

  该发明提供了式I的化合物，其中X，R.sup.1，R.sup.2和R.sup.3如描述中所定义。这些化合物具有有价值的杀真菌活性。
• Method for the in situ preparation of chiral compounds derived from oxazaborolidine-borane complexes which are used in asymmetric reduction reactions
  申请人：Burgos Alain

  公开号：US20070055068A1

  公开（公告）日：2007-03-08

  A process for the in situ preparation of chiral compounds derived from oxazaborolidine-borane complexes, wherein a metal borohydride, a Lewis base and an inorganic acid ester are brought together and an optically active amino alcohol and optionally a halide are then added. The compound obtained is a complex that is useful as a catalyst in asymmetric reduction reactions. The reaction is performed by adding the substance to be reduced, particularly prochiral ketones or ether oximes, in order to synthesize chiral alcohols or chiral amines.

  一种用于原位制备从氧杂硼烷硼酸盐复合物中衍生的手性化合物的方法，其中将金属硼氢化物、路易斯碱和无机酸酯混合，然后加入手性活性氨基醇和可选的卤化物。所得化合物是一种复合物，可用作不对称还原反应中的催化剂。通过将待还原物质，特别是原始手性酮或醚肟加入以合成手性醇或手性胺来执行反应。
• Compounds, pharmaceutical compositions, and methods for inhibiting cyclin-dependent kinases
  申请人：——

  公开号：US20030220326A1

  公开（公告）日：2003-11-27

  Pharmaceutical compositions containing effective amounts of CDK-inhibiting diaminothiazole compounds of the following formula (where R 1 and R 2 are as defined in the specification) or their salts, or prodrugs or active metabolites of such compounds or salts, are useful for treating disorders and diseases such as cancer: 1 In preferred embodiments, R 1 and R 2 are independently unsubstituted or substituted carbocyclic or heterocyclic aryl ring structures. Compounds where R 2 is ortho-substituted aryl are especially potent inhibitors of CDKs such as CDK4.

  含有以下公式中CDK抑制二氨基噻唑化合物的有效量的药物组合物（其中R1和R2如规范所定义）或其盐，或这些化合物或盐的前药或活性代谢物，可用于治疗癌症等疾病和疾病。在首选实施例中，R1和R2分别是未取代或取代的碳环或杂环芳香环结构。其中R2为邻位取代芳香族的化合物特别是CDKs如CDK4的有效抑制剂。