(2S)-(-)-Natrium-2-hydroxyvalerat

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2S)-(-)-Natrium-2-hydroxyvalerat
• 英文别名: (S)-2-hydroxy-valeric acid ; sodium-salt；(S)-2-Hydroxy-valeriansaeure; Natrium-Salz；sodium;(2S)-2-hydroxypentanoate
• 化学式: C₅H₉O₃*Na
• 分子量: 140.114
• InChiKey: DILAZWBRGXXDCF-WCCKRBBISA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -4.1
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  60.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  L-正缬氨酸 在 硫酸 、 sodium nitrite 作用下， 生成 (2S)-(-)-Natrium-2-hydroxyvalerat
  参考文献：
  名称：

  Cyanoalkyl difluoro-terphenyl-carboxylate chiral dopants

  摘要：

  A liquid crystal like difluoroterphenyl chiral dopant was synthesized to match the dimensions of a host chiral dopant mixture. The melting point of the chiral dopants was decreased by increasing the length of the alkyl chain. The melting point of the chiral dopants also decreased when fluorine was on the same ring as the ester i.e. at 2 '', 3 '' position. These dopants were formulated with terphenyl host mixture and liquid crystal properties were assessed. New dopants, when added to the host mixture, maintain SmA(1) but the SmC2 phase was reduced markedly. There was a decrease in spontaneous polarisation when fluorine was on the same ring as the ester i.e. at 2 '', 3 '' position. As the molecular weight of the chiral dopant increased (pentyl -> heptyl -> nonyl), spontaneous polarisation decreased. (C) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molliq.2012.03.018

文献信息

• Antibiotika aus Gleitenden Bakterien, XXVI. Konstitution und absolute Konfiguration der epimeren Myxovirescine A1 und A2
  作者：Wolfram Trowitzsch、Katrin Borgschulte、Victor Wray、Dietmar Schomburg、Gerhard Höfle

  DOI：10.1002/jlac.198519850809

  日期：1985.8.12

  Röntgenstrukturanalyse mit Kenntnis der absoluten Konfiguration des Abbauproduktes (2S)-(–)-Natrium-2-hydro-xyvalerat (9) von 1a, b die Zuordnung der absoluten Konfigurationen der sieben Asymmetriezentren im Myxovirescin A1 als 2S, 6S, 8S, 9R, 16R, 25R und 27S. Die Isolierung des rechtsdrehenden Dimethylesters der (2S, 4S)-2,4-Dimethyl-1,9-nonandisäure (10), erhalten aus Myxovirescin A2 durch oxidativen Abbau

  详述1D和2D 1 H和13上myxovirescins A C-NMR研究1和A 2（1A，B）和衍生物28，具有降解反应的结果一起，导致了一个28元的规定的构成内酰胺-内酯体系。构成的确定可以通过对粘菌素A 1（8）的双缩醛的X射线结构分析来确认。此外，借助1a，b的降解产物（2 S）-（-）-2-羟基戊酸钠（9）的绝对构型知识，X射线结构分析成为可能。七个粘蛋白的A 1 2 S，6 S，8 S，9 R，16 R，25 R和27 S的不对称中心的绝对构型的分配。通过氧化降解分离自粘霉素A 2获得的（2 S，4 S）-2,4-二甲基-1,9-壬二酸右旋二甲基酯（10），形成差向异构体A 2，（25 S）-固定配置。
• Cyanoalkyl difluoro-terphenyl-carboxylate chiral dopants
  作者：Zohra N. Kayani、Robert A. Lewis、Shahzad Naseem

  DOI：10.1016/j.molliq.2012.03.018

  日期：2012.6

  A liquid crystal like difluoroterphenyl chiral dopant was synthesized to match the dimensions of a host chiral dopant mixture. The melting point of the chiral dopants was decreased by increasing the length of the alkyl chain. The melting point of the chiral dopants also decreased when fluorine was on the same ring as the ester i.e. at 2 '', 3 '' position. These dopants were formulated with terphenyl host mixture and liquid crystal properties were assessed. New dopants, when added to the host mixture, maintain SmA(1) but the SmC2 phase was reduced markedly. There was a decrease in spontaneous polarisation when fluorine was on the same ring as the ester i.e. at 2 '', 3 '' position. As the molecular weight of the chiral dopant increased (pentyl -> heptyl -> nonyl), spontaneous polarisation decreased. (C) 2012 Elsevier B.V. All rights reserved.