7-(4-tert.-butyl-1-piperazinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-(4-tert.-butyl-1-piperazinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
• 英文别名: 7-(4-tert-butyl-1-piperazinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid；7-(4-tert-butylpiperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid
• 化学式: C₂₁H₂₆FN₃O₃
• 分子量: 387.454
• InChiKey: WUCSGFJKBKAOEP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  64.1
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  N-叔丁基哌嗪 、 1-环丙基-6,7-二氟-1,4-二氢-4-氧喹啉-3-羧酸 生成 7-(4-tert.-butyl-1-piperazinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
  参考文献：
  名称：

  PETERSEN, UWE;GROHE, KLAUS;ZEILER, HANS-JOACHIM;METZGER, KARL GEORG

  摘要：

  DOI：

文献信息

• 1-cyclopropy
  申请人：Bayer Aktiengesellschaft

  公开号：US04806539A1

  公开（公告）日：1989-02-21

  An antibacterial 1-cyclopropyl-6-fluoro-1,4- dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid of the formula ##STR1## in which R represents branched or straight-chain propyl or butyl which is optionally substituted by hydroxy or methoxy, unsubstituted tert.-butyl, 2-methylthioethyl, trifluoromethylthiomethyl, 2-trifluoromethylthioethyl, cycloalkyl with 3 to 6 carbon atoms, cycloalkenyl having 5 to 6 carbon atoms optionally substituted by hydroxyl, 1,1-dioxidotetrahydrothiophen-3-yl, cyclopropylmethyl, 1-phenethyl, furylmethyl, allyl or propargyl optionally substituted by phenyl and their pharmaceutically usable hydrates, acid addition salts, metal and guanidinium salts and prodrug forms.

  一种抗菌的1-环丙基-6-氟-1,4-二氢-4-氧基-7-(1-哌嗪基)-3-喹啉羧酸，其化学式为##STR1##其中R代表支链或直链的丙基或丁基，可选地被羟基或甲氧基取代，未取代的叔丁基，2-甲硫基乙基，三氟甲硫基甲基，2-三氟甲硫基乙基，环烷基（碳原子数为3至6），环戊烯基（碳原子数为5至6，可选地被羟基取代），1,1-二氧代四氢噻吩-3-基，环丙基甲基，1-苯乙基，呋喃基甲基，烯丙基或丙炔基，可选地被苯基取代，以及它们的药用水合物、酸盐、金属盐和胍啶盐以及前药形式。
• Compounds that inhibit cholinesterase
  申请人：Rupniak Nadia M. J.

  公开号：US20080261950A1

  公开（公告）日：2008-10-23

  Compounds that inhibit cholinesterase activity and, upon hydrolysis release a pharmacologically active agent. The compounds of the invention are employed in methods to treat an individual. The pharmacologically active agent obtained by hydrolysis of the compound can treat, for example, a nervous system condition, a cholinergic deficiency and conditions or diseases associated with a deficiency in a pharmacologically active agent, such as acetylcholine.
• US4806539A
  申请人：——

  公开号：US4806539A

  公开（公告）日：1989-02-21
• US8101782B2
  申请人：——

  公开号：US8101782B2

  公开（公告）日：2012-01-24