5-hydroxy-7-[6-(4-methyl-piperazin-1-yl)-hexyloxy]-2-phenyl-chromen-4-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 5-hydroxy-7-[6-(4-methyl-piperazin-1-yl)-hexyloxy]-2-phenyl-chromen-4-one
• 英文别名: 5-Hydroxy-7-[6-(4-methylpiperazin-1-yl)hexoxy]-2-phenylchromen-4-one
• 化学式: C₂₆H₃₂N₂O₄
• 分子量: 436.551
• InChiKey: QBCIVMIDOWQJTE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  62.2
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  白杨素 在 potassium carbonate 作用下， 以 丙酮 、 乙腈 为溶剂， 生成 5-hydroxy-7-[6-(4-methyl-piperazin-1-yl)-hexyloxy]-2-phenyl-chromen-4-one
  参考文献：
  名称：

  Synthesis and biological evaluation of novel C (7) modified chrysin analogues as antibacterial agents

  摘要：

  The natural product, chrysin (5,7-dihydroxy flavone), obtained from Oroxylum indicum, exhibits numerous biological activities including anticancer, anti-inflammatory, and antiallergic activities. Three series of chrysin analogues were prepared, in which chrysin and heterocyclic moieties are separated by 3-carbon, 4-carbon, and 6-carbon spacers. All the derivatives were screened for antibacterial activity against a panel of susceptible and resistant Gram-positive and Gram-negative organisms. It was observed that most of the derivatives displayed significant activity as compared to their parent compound (chrysin). (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.09.009

文献信息

• [EN] FLAVANOID COMPOUNDS AND PROCESS FOR PREPARATION THEREOF<br/>[FR] COMPOSÉS FLAVANOÏDES ET LEUR PROCÉDÉ DE PRÉPARATION
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2010097816A1

  公开（公告）日：2010-09-02

  The present invention relates to flavanoid compounds of general formula (X1) wherein: R1 is selected from a group consisting of morpholinyl, N-methyl piperizinyl, piperidinyl and N,N'-dimethylamino groups, and n ranges from 3 to 6, and process for preparation thereof. The present invention relates to the demonstration of anti Helicobacter pylori activity and gastric antisecretory activity of semisynthetically designed flavonoid compounds, to be used for the prevention and treatment of gastroduodenal disorders in general and peptic ulcer diseases in particular. The present invention also relates to a hetero-dimeric bi-functional molecule that can be used as monotherapy substituting/replacing/overcoming currently used triple/quadruple therapy, thereby implicating/ anticipating/envisaging its commercial applicability.

  本发明涉及一般式为（X1）的黄酮类化合物，其中：R1从包括吗啡啶基、N-甲基哌嗪基、哌啶基和N,N'-二甲基氨基等基团中选择，n的范围为3至6，并涉及其制备方法。本发明涉及半合成设计的黄酮类化合物展示抗幽门螺杆菌活性和胃分泌抑制活性，可用于预防和治疗胃十二指肠疾病，特别是消化性溃疡。本发明还涉及一种异源二聚体双功能分子，可用作单疗法替代/取代/克服目前使用的三联/四联疗法，从而暗示/预期/设想其商业适用性。
• Flavanoid Compounds and Process for Preparation Thereof
  申请人：Dab Pratap Kumar

  公开号：US20120022062A1

  公开（公告）日：2012-01-26

  The present invention relates to flavanoid compounds of general formula (X 1 ) wherein: R 1 is selected from a group consisting of morpholinyl, N-methyl piperizinyl, piperidinyl and N,N′-dimethylamino groups, and n ranges from 3 to 6, and process for preparation thereof. The present invention relates to the demonstration of anti Helicobacter pylori activity and gastric antisecretory activity of semisynthetically designed flavonoid compounds, to be used for the prevention and treatment of gastroduodenal disorders in general and peptic ulcer diseases in particular. The present invention also relates to a hetero-dimeric bi-functional molecule that can be used as monotherapy substituting/replacing/overcoming currently used triple/quadruple therapy, thereby implicating/anticipating/envisaging its commercial applicability.
• FLAVANOID COMPOUNDS AND PROCESS FOR PREPARATION THEREOF
  申请人：Council of Scientific & Industrial Research

  公开号：US20150174135A1

  公开（公告）日：2015-06-25

  The present invention relates to flavanoid compounds of general formula (X 1 ) wherein: R 1 is selected from a group consisting of morpholinyl, N-methyl piperizinyl, piperidinyl and N,N′-dimethylamino groups, and n ranges from 3 to 6, and process for preparation thereof. The present invention relates to the demonstration of anti Helicobacter pylori activity and gastric antisecretory activity of semisynthetically designed flavonoid compounds, to be used for the prevention and treatment of gastroduodenal disorders in general and peptic ulcer diseases in particular. The present invention also relates to a hetero-dimeric bi-functional molecule that can be used as monotherapy substituting/replacing/overcoming currently used triple/quadruple therapy, thereby implicating/anticipating/envisaging its commercial applicability.
• US8969384B2
  申请人：——

  公开号：US8969384B2

  公开（公告）日：2015-03-03
• US9642854B2
  申请人：——

  公开号：US9642854B2

  公开（公告）日：2017-05-09