8-[(Benzylamino)methyl]-5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one | 1021312-22-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 8-[(Benzylamino)methyl]-5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one
• CAS: 1021312-22-0
• 化学式: C₂₄H₂₁NO₅
• 分子量: 403.434
• InChiKey: SHBYBASYBOOIOO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  88
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 千层纸素A 、 苄胺 以 异丙醇 为溶剂， 生成 8-[(Benzylamino)methyl]-5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one
  参考文献：
  名称：

  Synthesis and biological evaluation of novel 8-aminomethylated oroxylin A analogues as α-glucosidase inhibitors

  摘要：

  A series of 8-aminomethylated derivatives (1a-1j) were prepared by Mannich reaction of oroxylin A (1) with appropriate primary or secondary amines and para-formaldehyde. All the compounds were tested for their alpha-glucosidase inhibition activity against both yeast and rat intestinal alpha-glucosidase. Some of the compounds demonstrated significantly better alpha-glucosidase inhibitory activity than the parent compound (oroxylin A). (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.01.055