6-hydroxyhexanoic acid dodecyl amide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 6-hydroxyhexanoic acid dodecyl amide
• 英文别名: 6-hydroxy-N-laurylhexylamide；N-dodecyl-6-hydroxyhexanamide
• 化学式: C₁₈H₃₇NO₂
• 分子量: 299.497
• InChiKey: BLRXUEBCZRKDKH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  21
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-hydroxyhexanoic acid dodecyl amide 、 氯甲酸三氯甲酯 在 吡啶 作用下， 以 四氢呋喃 为溶剂， 以63%的产率得到bis(5-dodecylaminocarbonylpentyl) carbonate
  参考文献：
  名称：

  Synthesis and transdermal penetration-enhancing activity of carbonic and carbamic acid esters—Comparison with transkarbam 12

  摘要：

  Transkarbam 12 (T12) is a novel transdermal penetration enhancer with high activity. Its polar head group is formed by carbamic acid salt that is unstable in acidic environment and releases CO2 To find out whether this property influences its high activity, two series of compounds with CO2 stronger bound in the polar head have been prepared-carbonic and carbamic acid esters. The carbamate salt in the polar head was found to be essential for the enhancing activity and its decomposition in an acidic environment suggested relating to the mode of action of T12. (C) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.12.086
• 作为产物：
  描述：

  6-己内酯 、 十二烷基伯胺 在 sodium methylate 作用下， 反应 1.0h， 生成 6-hydroxyhexanoic acid dodecyl amide
  参考文献：
  名称：

  COSMETIC BASE INCLUDING AMIDE ALCOHOL, AND COSMETIC

  摘要：

  本发明的目的是提供一种可用作化妆品基础成分的新型酰胺醇。一种由式（I）所表示的酰胺醇。

  公开号：

  US20190343745A1

文献信息

• COSMETIC BASE INCLUDING AMIDE ALCOHOL, AND COSMETIC
  申请人：Kokyu Alcohol Kogyo Co., Ltd.

  公开号：US20190343745A1

  公开（公告）日：2019-11-14

  The purpose of the present invention is to provide a novel amide alcohol that can be used as a cosmetic base ingredient. An amide alcohol represented by formula (I).

  本发明的目的是提供一种可用作化妆品基础成分的新型酰胺醇。一种由式（I）所表示的酰胺醇。
• Complex and emulsion composition
  申请人：Kokyu Alcohol Kogyo Co., Ltd.

  公开号：US10729629B2

  公开（公告）日：2020-08-04

  [Problem] An object of the invention is to provide a novel complex that can be used as an emulsifier. [Solving means] A complex in which an amide alcohol and a carboxyl group-containing polymer exerts an excellent emulsifying power for oil having a wide range of required HLB.

  [问题] 本发明的目的是提供一种可用作乳化剂的新型复合物。 [解决方法]一种酰胺醇和含羧基聚合物的复合物对具有广泛 HLB 要求的油类具有极佳的乳化能力。
• Cosmetic base including amide alcohol, and cosmetic
  申请人：Kokyu Alcohol Kogyo Co., Ltd.

  公开号：US11083677B2

  公开（公告）日：2021-08-10

  The purpose of the present invention is to provide a novel amide alcohol that can be used as a cosmetic base ingredient. An amide alcohol represented by formula (I).

  本发明的目的是提供一种可用作化妆品基础成分的新型酰胺醇。由式（I）代表的酰胺醇。
• EP3756645A1
  申请人：——

  公开号：EP3756645A1

  公开（公告）日：2020-12-30
• NOVEL COMPLEX AND EMULSION COMPOSITION
  申请人：KOKYU ALCOHOL KOGYO CO., Ltd.

  公开号：US20190125644A1

  公开（公告）日：2019-05-02

  [Problem] An object of the invention is to provide a novel complex that can be used as an emulsifier. [Solving means] A complex in which an amide alcohol and a carboxyl group-containing polymer exerts an excellent emulsifying power for oil having a wide range of required HLB.