17-Chloro-16,18-dioxa-17-phosphaheptacyclo[17.12.0.02,15.03,8.09,14.020,25.026,31]hentriaconta-1(19),2(15),3,5,7,9,11,13,20,22,24,26,28,30-tetradecaene

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 17-Chloro-16,18-dioxa-17-phosphaheptacyclo[17.12.0.02,15.03,8.09,14.020,25.026,31]hentriaconta-1(19),2(15),3,5,7,9,11,13,20,22,24,26,28,30-tetradecaene
• 化学式: C₂₈H₁₆ClO₂P
• 分子量: 450.861
• InChiKey: BAYJBHBEHHMAQQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.1
• 重原子数：
  32
• 可旋转键数：
  0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  亚氨基芪 、 17-Chloro-16,18-dioxa-17-phosphaheptacyclo[17.12.0.02,15.03,8.09,14.020,25.026,31]hentriaconta-1(19),2(15),3,5,7,9,11,13,20,22,24,26,28,30-tetradecaene 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 1.0h， 生成 (+)-5-((11bS)-diphenanthro[9,10-d:9',10'-f][1,3,2]dioxaphosphepin-2-yl)-5H-dibenzo[b,f]azepine
  参考文献：
  名称：

  外消旋烯丙醇的直接，对映选择性铱催化的烯丙基胺化

  摘要：

  直接途径：铱催化的支链烯丙基醇直接转化为对映体富集的支链伯烯丙基胺具有很高的区域和对映选择性（见方案； coe =环辛烯）。

  DOI：

  10.1002/anie.201108287
• 作为产物：
  描述：

  rac-10,10'-dihydroxy-9,9'-biphenanthryl 在 吡啶 、 三氯化磷 作用下， 以 甲苯 为溶剂， 生成 17-Chloro-16,18-dioxa-17-phosphaheptacyclo[17.12.0.02,15.03,8.09,14.020,25.026,31]hentriaconta-1(19),2(15),3,5,7,9,11,13,20,22,24,26,28,30-tetradecaene
  参考文献：
  名称：

  用于铜的对映选择性铜催化的1,4-加成的新手性恶唑啉-亚磷酸酯配体

  摘要：

  制备了一系列具有联萘基和恶唑啉部分的新的P，N-配体，它们是对映选择性铜催化的有机锌试剂向烯酮的1,4-加成反应的有效配体。在二乙基锌与环戊烯酮的反应中，将联萘的3,3'-位的空间体积从H增加到联苯基部分，可将ee从65％提高到94％。

  DOI：

  10.1016/s0040-4020(00)00143-5

文献信息

• Catalytic Asymmetric Intramolecular Hydroacylation with Rhodium/Phosphoramidite-Alkene Ligand Complexes
  作者：Thomas J. Hoffman、Erick M. Carreira

  DOI：10.1002/anie.201104595

  日期：2011.11.4

  Give me a P: An asymmetric intramolecular Rh‐catalyzed hydroacylation reaction of pent‐4‐enals for the preparation of functionalized cyclopentanones in good yield and high enantioselectivity is described (see scheme, DCE=dichloroethane). This process uses rhodium complexes featuring novel modular phosphoramidite–alkene ligands and achiral phosphine coligands.

  给我一个P：描述了戊4-烯醛的不对称分子内Rh催化加氢酰化反应，以高收率和高对映选择性制备官能化的环戊酮（参见方案，DCE =二氯乙烷）。该工艺使用具有新型模块化亚磷酰胺-烯烃配体和非手性膦大分子配体的铑配合物。
• Phosphine compounds, complexes containing the phosphine compounds as ligands, process for producing optically active aldehydes using the phosphine compounds, or complexes, and 4-[(R)-1' formylethyl]azetidin-2-one derivatives
  申请人：Takasago International Corporation

  公开号：EP0614903A2

  公开（公告）日：1994-09-14

  Novel phosphine compounds are represented by formulae (I) and (II): wherein the R substituents have the significations defined in the specification and are useful in the form of their transition metal complexes, or of compounds with transition metals, in producing an optically active aldehyde by hydroformylation of an olefin with high positional and steric selectivities. A 4-[(R)-1'-formylethyl]azetidin-2-one derivative obtainable by the process is particularly useful as an intermediate for the preparation of carbapenem antibiotics.

  新颖的膦化合物由式 (I) 和 (II) 表示： 其中 R 取代基具有说明书中定义的含义，以其过渡金属络合物或与过渡金属的化合物的形式，通过烯烃的氢甲酰化生产光学活性醛，具有高位置选择性和立体选择性。通过该工艺获得的 4-[(R)-1'-甲酰基乙基]氮杂环丁烷-2-酮衍生物尤其可用作制备碳青霉烯类抗生素的中间体。
• Phosphine compounds, complexes containing the phosphine compounds as ligands, and process for producing optically active aldehydes using the phosphine compounds or complexes
  申请人：Takasago International Corporation

  公开号：EP0684249A1

  公开（公告）日：1995-11-29

  Novel phosphine compounds are represented by formulae (I) and (II): wherein the R substituents have the significations defined in the specification and are useful in the form of their transition metal complexes, or of compounds with transition metals, in producing an optically active aldehyde by hydroformylation of an olefin with high positional and steric selectivities.

  新颖的膦化合物由式 (I) 和 (II) 表示： 其中 R 取代基具有说明书中定义的含义，以其过渡金属络合物或与过渡金属的化合物的形式，通过烯烃的氢甲酰化反应生产光学活性醛时，具有高位置选择性和立体选择性。
• Synthesis and Catalytic Application of Chiral 1,1‘-Bi-2-naphthol- and Biphenanthrol-Based Pincer Complexes:  Selective Allylation of Sulfonimines with Allyl Stannane and Allyl Trifluoroborate
  作者：Juhanes Aydin、K. Senthil Kumar、Mahmoud J. Sayah、Olov A. Wallner、Kálmán J. Szabó

  DOI：10.1021/jo070288b

  日期：2007.6.1

  New easily accessible 1,1'-bi-2-naphthol- (BINOL-) and biphenanthrol-based chiral pincer complex catalysts were prepared for selective (up to 85% enantiomeric excess) allylation of sulfonimines. The chiral pincer complexes were prepared by a flexible modular approach allowing an efficient tuning of the selectivity of the catalysts. By employment of the different enantiomeric forms of the catalysts, both enantiomers of the homoallylic amines could be selectively obtained. Both allyl stannanes and allyl trifluoroborates can be employed as allyl sources in the reactions. The biphenanthrol-based complexes gave higher selectivity than the substituted BINOL-based analogues, probably because of the well-shaped chiral pocket generated by employment of the biphenanthrol complexes. The enantioselective allylation of sulfonimines presented in this study has important implications for the mechanism given for the pincer complex-catalyzed allylation reactions, confirming that this process takes place without involvement of palladium(0) species.
• Process for producing optically active aldehydes using transition metal-phosphine complexes, and process for producing intermediates for carbapenem antibiotics using the same complexes
  申请人：Takasago International Corporation

  公开号：EP0614903B1

  公开（公告）日：2000-09-20