Light, GSH, action! Glutathione (GSH) fulfills a universal role as redox factor, scavenger of reactive oxygen species, and as an essential substrate in the conjugation, detoxification, and reduction reactions catalyzed by glutathione S‐transferase (GST). A photoactivatable glutathione allows the GSH‐GST network to be triggered by light. GST fusion proteins can be assembled in situ at variable density
[EN] COMPOUNDS FOR DELIVERING GLUTATHIONE TO A TARGET AND METHODS OF MAKING AND USING THE SAME<br/>[FR] COMPOSÉS POUR L'ADMINISTRATION DE GLUTATHION À UNE CIBLE ET PROCÉDÉS POUR LES PRÉPARER ET LES UTILISER
申请人:UNIV OREGON STATE
公开号:WO2017214297A1
公开(公告)日:2017-12-14
Disclosed herein are embodiments of compounds that can be used to target glutathione to various target sites, such as cells, mitochondria, and other organelles. Also disclosed herein are embodiments of methods for making and using the compounds. In particular disclosed embodiments, the compounds can be used to treat, ameliorate, and/or prevent diseases or conditions associated with low or reduced glutathione levels, as well as other types of diseases/conditions.
Novel derivatives of morphine-6-glucuronide, pharmaceutical compositions containing them, their preparation method and their uses
申请人:Temsamani Jamal
公开号:US20070116665A1
公开(公告)日:2007-05-24
The invention relates to novel derivatives of morphine-6-glucuronide, the preparation method thereof and the uses of same in therapy, for example, as analgesics.
Efficient Esterification of Oxidized l-Glutathione and Other Small Peptides
作者:Emily Vogel、William Jackson、Douglas Masterson
DOI:10.3390/molecules200610487
日期:——
tetra methyl ester using thionylchloride in methanol solvent. Other alcohols were tested and the reaction progress was monitored via ESI-MS. This procedure proved to be compatible with other small peptides not containing serine and cysteine residues. In contrast to previously reported methods this procedure provided convenient access to esterified peptides requiring no purification, extended reaction times
The comprehensive acid–base characterization of glutathione
作者:Arash Mirzahosseini、Máté Somlyay、Béla Noszál
DOI:10.1016/j.cplett.2015.01.020
日期:2015.2
Glutathione in its thiol (GSH) and disulfide (GSSG) forms, and 4 related compounds were studied by 1H NMR-pH titrations and a case-tailored evaluation method. The resulting acid-base properties are quantified in terms of 128 microscopic protonation constants; the first complete set of such parameters for this vitally important pair of compounds. The concomitant 12 interactivity parameters were also determined. Since biological redox systems are regularly compared to the GSH-GSSG pair, the eight microscopic thiolate basicities determined this way are exclusive means for assessing subtle redox parameters in a wide pH range. (c) 2015 Elsevier B.V. All rights reserved.