6-十四烷酮 | 6836-42-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 6-十四烷酮
• 英文名称: 6-tetradecanone
• 英文别名: tetradecan-6-one
• CAS: 6836-42-6
• 化学式: C₁₄H₂₈O
• 分子量: 212.376
• InChiKey: OAFHCOXSIJKFEV-UHFFFAOYSA-N

物化性质

• 熔点：
  38.18°C (estimate)
• 沸点：
  277.23°C (estimate)
• 密度：
  0.8256 (estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  15
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2914190090

反应信息

• 作为反应物：
  描述：

  6-十四烷酮 在 lithium aluminium deuteride 作用下， 生成
  参考文献：
  名称：

  Enantiomeric Analysis of Homologous Series of Secondary Alcohols by Deuterium NMR Spectroscopy in a Chiral Nematic Liquid Crystal: Influence of Molecular Geometry on Chiral Discrimination

  摘要：

  NMR measurements of the differential ordering effect (DOE) are presented for homologous series of 22 chiral secondary aliphatic alcohols dissolved in a poly-(gamma-benzyl-L-glutamate) (PBLG)/dichloromethane liquid-crystalline solvent. The quadrupolar splittings of the solutes, which were deuterated at their chiral centres, were measured as a function of the PBLG concentration and temperature. The proton dipolar splittings of the dichloromethane in each sample were also measured and used as a reference. The results are analysed qualitatively in terms of the structures of the molecules and their asymmetric (or chiral) characteristics. Emphasis is put on comparative analysis of the chiral discrimination in members of each particular homologous series and on evaluating the Limits of the technique for molecules that have two very similar groups attached to their stereogenic centres.

  DOI：

  10.1002/(sici)1521-3765(19980710)4:7<1142::aid-chem1142>3.0.co;2-q
• 作为产物：
  描述：

  正辛基镁溴盐 在 potassium dichromate 、 硫酸 作用下， 以 乙醚 为溶剂， 生成 6-十四烷酮
  参考文献：
  名称：

  Studt,P., Justus Liebigs Annalen der Chemie, 1966, vol. 693, p. 90 - 98

  摘要：

  DOI：

文献信息

• Facile synthesis of ketones from 1,1-disilylethenes via oxidation of gem-disilylalkanes
  作者：Atsushi Inoue、Junichi Kondo、Hiroshi Shinokubo、Koichiro Oshima

  DOI：10.1039/b109656g

  日期：2002.1.18

  The oxidation of gem-disilylalkanes, which can be derived from 1,1-disilylethene, alkyllithiums and alkyl halides, affords the corresponding ketones.

  可以衍生自1，1-二甲硅烷基乙烯，烷基锂和卤代烷的宝石-二甲硅烷基烷烃的氧化得到相应的酮。
• A Novel Synthesis of Internal Alkenyldialkylborane by the Reaction of 1-Halo-1-alkenyldialkylborane with Grignard Reagent
  作者：Akira Arase、Masayuki Hoshi、Yuzuru Masuda

  DOI：10.1246/bcsj.57.209

  日期：1984.1

  To synthesize internal alkenyldialkylboranes, coupling reactions were carried out by using 1-halo-l-alkenyldialkylboranes and Grignard reagents. Hydrogen peroxide oxidation and protonolysis with acetic acid of the reaction product revealed that internal (E)-alkenyldialkylborane was formed in 60–90% yield.

  为了合成内部烯基二烷基硼烷，通过使用 1-卤代-l-烯基二烷基硼烷和格氏试剂进行偶联反应。过氧化氢氧化和反应产物的乙酸质子分解表明，内部 (E)-烯基二烷基硼烷以 60-90% 的产率形成。
• [EN] NEW AZASPIRODECANONE COMPOUNDS AS HSL INHIBITORS<br/>[FR] NOUVEAUX COMPOSÉS D'AZASPIRODÉCANONE EN TANT QU'INHIBITEURS DE LA HSL
  申请人：HOFFMANN LA ROCHE

  公开号：WO2012130679A1

  公开（公告）日：2012-10-04

  The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5 and A are as described herein, compositions including the compounds and methods of using the compounds.

  这项发明提供了具有通式（I）的新化合物，其中R1、R2、R3、R4、R5和A如本文所述，包括这些化合物的组合物以及使用这些化合物的方法。
• Reaction of Unstabilized Iodonium Ylides with Organoboranes
  作者：Masahito Ochiai、Yoshimi Tuchimoto、Nobuyuki Higashiura

  DOI：10.1021/ol0495669

  日期：2004.4.1

  [reaction: see text] Exposure of monocarbonyl iodonium ylides, generated by the ester exchange of (Z)-(2-acetoxyvinyl)-lambda(3)-iodanes with EtOLi, to organoboranes results in a 1,2-shift of a carbon ligand from boron to the ylide carbons, which probably generates hitherto uncharacterized alpha-boryl ketones.

  [反应：请参阅文本]通过（Z）-（2-乙酰氧基乙烯基）-λ（3）-碘酮与EtOLi的酯交换产生的单羰基碘鎓烷基化物暴露于有机硼烷会导致碳的1,2-转移从硼到内含碳的配体，可能会产生迄今未表征的α-硼基酮。
• [EN] SEC-HYDROXYCYCLOHEXYL DERIVATIVES AS HSL INHIBITORS FOR THE TREATMENT DIABETES<br/>[FR] DÉRIVÉS SEC-HYDROXYCYCLOHEXYLES EN TANT QU'INHIBITEUR DE HSL POUR LE TRAITEMENT DU DIABÈTE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2012123432A1

  公开（公告）日：2012-09-20

  The invention provides novel compounds having the general formula (I) wherein R1, R2 and R3 are as described herein, and compositions including the compounds. The use of the compounds as inhibitors of hormone sensitive lipose (HSL) for the treatment of diseases such as diabetes and metabolic symdrome is also disclosed.

  这项发明提供了具有通式（I）的新化合物，其中R1、R2和R3如本文所述，并包括这些化合物的组合物。还披露了将这些化合物用作激素敏感性脂肪酶（HSL）的抑制剂，用于治疗糖尿病和代谢综合征等疾病。

表征谱图