11-碘十一烷酸乙酯 | 53821-20-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 11-碘十一烷酸乙酯
• 中文别名: 11-碘十一酸乙酯
• 英文名称: ethyl 11-iodoundecanoate
• 英文别名: ethyl 11-iodoundecoate；11-iodo-undecanoic acid ethyl ester；11-Jod-undecansaeure-aethylester；11-Jod-undecylsaeure-aethylester；Ethyl-11-iodundecanoat；Ethyl-11-iodoundecanoate
• CAS: 53821-20-8
• 化学式: C₁₃H₂₅IO₂
• 分子量: 340.245
• InChiKey: MSUXYGAHHGIEFE-UHFFFAOYSA-N

物化性质

• 沸点：
  175-179 °C(Press: 6 Torr)
• 密度：
  1.281±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  16
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2915900090

反应信息

• 作为反应物：
  描述：

  11-碘十一烷酸乙酯 在 potassium carbonate 、 2-戊酮 作用下， 生成 戊酸,2-甲基-4-羰基-,甲基酯,(2S)-
  参考文献：
  名称：

  Bergstroem et al., Acta Chemica Scandinavica (1947), 1952, vol. 6, p. 1157,1160, 1169

  摘要：

  DOI：
• 作为产物：
  描述：

  11-溴代十一烷酸乙酯 在 sodium iodide 作用下， 以 丁酮 为溶剂， 生成 11-碘十一烷酸乙酯
  参考文献：
  名称：

  Synthesis of 13-Oxo-(Z)-9-octadecenoic Acid and 15-Oxo-(Z)-11-icosenoic Acid, Arrestants ofOryzaephilus surinamensisL.

  摘要：

  首次利用 Z 选择性维蒂希反应合成了锯齿禾甲虫（Oryzaephilus surinamensis L.）的两种捕食剂 13-氧代-(Z)-9-十八烯酸和 15-氧代-(Z)-11-二十烯酸。

  DOI：

  10.1271/bbb.61.551

文献信息

• 1, 2-Dioxetane derivatives and reagents employing them
  申请人：TOSOH CORPORATION

  公开号：US20030207329A1

  公开（公告）日：2003-11-06

  A 1,2-dioxetane derivative of the formula (I): 1 wherein Ar is an aryl group which may have an alkyl group, an aryl group, a halogen atom, an alkoxyl group, a carboxyl group, a formyl group, an alkyl ester, an aryl ester, an alkylketone, an arylketone or a hetero ring bonded thereto, X is a substituent capable of labeling an organic compound or a biological molecule, or an ester, Y is a hydrogen atom, an acyl group or a group of the formula —Si(R 4 R 5 R 6 ) (wherein each of R 4 , R 5 and R 6 which are independent of one another, is an alkyl group or an aryl group), Z is an alkyl group, an aryl group, an oxygen atom, a sulfur atom, a carbonyl group, —(CO)—O—, —O—(CO)—, —NH—, —NH—CO—, —CO—NH—, —OSi(R 7 R 8 )— (wherein each of R 7 and R 8 which are independent of each other, is an alkyl group or aryl group) or a group of the formula —(R 9 R 10 )SiO— (wherein each of R 9 and R 10 which are independent of each other, is an alkyl group or an aryl group), each of R 1 and R 2 is an alkyl group or an aryl group, and R 3 is a spacer.

  Ar是一个可能带有烷基，芳香基，卤素原子，烷氧基，羧基，甲酰基，烷基酯，芳基酯，烷基酮，芳基酮或异环与之结合的芳基，X是能够标记有机化合物或生物分子的取代基，或酯，Y是氢原子，酰基或式—Si(R4R5R6)的基团（其中R4、R5和R6各自独立，是烷基或芳基），Z是烷基，芳基，氧原子，硫原子，羰基，—(CO)—O—，—O—(CO)—，—NH—，—NH—CO—，—CO—NH—，—OSi(R7R8)—（其中R7和R8各自独立，是烷基或芳基）或式—(R9R10)SiO—（其中R9和R10各自独立，是烷基或芳基），R1和R2各自是烷基或芳基，R3是一个间隔物。
• 1, 2-dioxetane derivatives and reagents employing them
  申请人：Matsumoto Masakatsu

  公开号：US20050153365A1

  公开（公告）日：2005-07-14

  A 1,2-dioxetane derivative of the formula (I): wherein Ar is an aryl group which may have an alkyl group, an aryl group, a halogen atom, an alkoxyl group, a carboxyl group, a formyl group, an alkyl ester, an aryl ester, an alkylketone, an arylketone or a hetero ring bonded thereto, X is a substituent capable of labeling an organic compound or a biological molecule, or an ester, Y is a hydrogen atom, an acyl group or a group of the formula —Si(R 4 R 5 R 6 ) (wherein each of R 4 , R 5 and R 6 which are independent of one another, is an alkyl group or an aryl group), Z is an alkyl group, an aryl group, an oxygen atom, a sulfur atom, a carbonyl group, —(CO)—O—, —O—(CO)—, —NH—, —NH—CO—, —CO—NH—, —OSi(R 7 R 8 )— (wherein each of R 7 and R 8 which are independent of each other, is an alkyl group or aryl group) or a group of the formula —(R 9 R 10 )SiO— (wherein each of R 9 and R 10 which are independent of each other, is an alkyl group or an aryl group), each of R 1 and R 2 is an alkyl group or an aryl group, and R 3 is a spacer.

  化合物的化学式为(I)的1,2-二氧杂环丙烷衍生物，其中Ar是一个芳基基团，可以带有一个烷基，一个芳基，一个卤素原子，一个烷氧基，一个羧基，一个甲酰基，一个烷基酯，一个芳基酯，一个烷基酮，一个芳基酮或与之结合的杂环，X是一个能够标记有机化合物或生物分子的取代基或酯基，Y是氢原子，酰基或公式—Si(R4R5R6)的基团（其中R4，R5和R6各自独立地是烷基或芳基），Z是烷基，芳基，氧原子，硫原子，羰基，—(CO)—O—，—O—(CO)—，—NH—，—NH—CO—，—CO—NH—，—OSi(R7R8)—（其中R7和R8各自独立地是烷基或芳基）或公式—(R9R10)SiO—的基团（其中R9和R10各自独立地是烷基或芳基），R1和R2各自是烷基或芳基，而R3是一个间隔基团。
• Lipids and lipid assemblies comprising transfection enhancer elements
  申请人：Panzner Steffen

  公开号：US20080306153A1

  公开（公告）日：2008-12-11

  Lipid assemblies, such as liposomes, comprising transfection enhancer elements (TEE's), which are complexed with the lipid assemblies by means of ionic interactions, or lipids incorporating such TEE's are disclosed for enhancing the fusogenicity of the lipid assemblies. The TEE's have the formula: hydrophobic moiety-pH sensitive hydrophilic moiety  (II) The pH sensitive hydrophilic moiety of each TEE is a weak acid having a pka of between 2 and 6 or a zwitterionic structure comprising a combination of acidic groups with weak bases having a pKa of between 3 and 8. Lipids incorporating one or more such TEEs have the formula (I): Lipid moiety-[Hydrophobic moiety-pH sensitive hydrophilic moiety]  (I)

  本发明揭示了包含转染增强元素（TEE）的脂质组装体，例如脂质体，这些TEE通过离子相互作用与脂质组装体形成复合物，或者包含此类TEE的脂质。这些TEE的公式为：疏水基团-pH敏感亲水基团（II）。每个TEE的pH敏感亲水基团是一种弱酸，其pka在2到6之间，或者是包含酸性基团和pKa在3到8之间的弱碱性基团的双电离结构的组合。包含一个或多个此类TEE的脂质的公式为（I）：脂质基团-[疏水基团-pH敏感亲水基团]（I）。该发明旨在提高脂质组装体的融合性。
• 1,2-dioxetane derivates and reagents employing them
  申请人：Tosoh Corporation

  公开号：EP1342724A1

  公开（公告）日：2003-09-10

  A 1,2-dioxetane derivative of the formula (I): wherein Ar is an aryl group which may have an alkyl group, an aryl group, a halogen atom, an alkoxyl group, a carboxyl group, a formyl group, an alkyl ester, an aryl ester, an alkylketone, an arylketone or a hetero ring bonded thereto, X is a substituent capable of labeling an organic compound or a biological molecule, or an ester, Y is a hydrogen atom, an acyl group or a group of the formula -Si(R4R5R6) (wherein each of R4, R5 and R6 which are independent of one another, is an alkyl group or an aryl group), Z is an alkyl group, an aryl group, an oxygen atom, a sulfur atom, a carbonyl group, -(CO)-O-, -O-(CO)-, -NH-, -NH-CO-, -CO-NH-, -OSi(R7R8)- (wherein each of R7 and R8 which are independent of each other, is an alkyl group or aryl group) or a group of the formula -(R9R10) SiO- (wherein each of R9 and R10 which are independent of each other, is an alkyl group or an aryl group), each of R1 and R2 is an alkyl group or an aryl group, and R3 is a spacer.

  式(I)的 1,2-二氧杂环丁烷衍生物： 其中 Ar 是芳基，可具有烷基、芳基、卤素原子、烷氧基、羧基、甲酰基、烷基酯、芳基酯、烷基酮、芳基酮或以其键合的杂环、Y 是氢原子、酰基或式 -Si(R4R5R6)的基团（其中 R4、R5 和 R6 各自独立、是烷基或芳基），Z 是烷基、芳基、氧原子、硫原子、羰基、-(CO)-O-、-O-(CO)-、-NH-、-NH-CO-、-CO-NH-、-OSi(R7R8)-（其中 R7 和 R8 各自独立、或式 -(R9R10) SiO- 的基团（其中 R9 和 R10 彼此独立，各自为烷基或芳基），R1 和 R2 各自为烷基或芳基，R3 为间隔物。
• Buu-Hoi; Cagniant; Royer, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1946, vol. 222, p. 224
  作者：Buu-Hoi、Cagniant、Royer

  DOI：——

  日期：——