11-碘十一碳-10-酸苯酯 | 2020-25-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 中文名称: 11-碘十一碳-10-酸苯酯
• 英文名称: 11-Iod-10-undecynoesaeure-phenylester
• 英文别名: 11-Iod-10-undecin-saeurephenylester；Phenyliodoundecynoate；phenyl 11-iodoundec-10-ynoate
• CAS: 2020-25-9
• 化学式: C₁₇H₂₁IO₂
• 分子量: 384.257
• InChiKey: YXYXRFVXKCHITA-UHFFFAOYSA-N

物化性质

• 沸点：
  439.1±28.0 °C(Predicted)
• 密度：
  1.383±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  20
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2916190090

文献信息

• Imidazole derivatives and processes for their production
  申请人：Kaken Pharmaceutical Co., Ltd.

  公开号：EP0134578A2

  公开（公告）日：1985-03-20

  An imidazole derivative represented by the general formula I or a biologically acceptable acid addition salt thereof: where Ar is a phenyl group which may be substituted by alkyl having from 1 to 6 carbon atoms, alkoxy having from 1 .to 4 carbon atoms, alkylamino having from 1 to 4 carbon atoms, alkoxy carbonyl having from 1 to 4 carbon atoms, phenyl, halogen or hydroxyl; a naphthyl group; a furyl group; or a thienyl group which may be substituted by halogen or alkyl having from 1 to 4 carbon atoms, and R is an alkyl group having from 1 to 10 carbon atoms; an alkenyl group having from 1 to 6 carbon atoms; or a phenylalkyl group which may be substituted by halogen.

  通式 I 所代表的咪唑衍生物或其生物可接受的酸加成盐： 其中 Ar 是苯基，可被 1 至 6 个碳原子的烷基、1 .至 4 个碳原子的烷基、1 至 4 个碳原子的烷基氨基、1 至 4 个碳原子的烷氧基羰基、苯基、卤素或羟基；萘基；呋喃基；或可被卤素或 1 至 4 个碳原子的烷基取代的噻吩基；R 是 1 至 10 个碳原子的烷基；1 至 6 个碳原子的烯基；或可被卤素取代的苯基烷基。
• Azacycloalkane derivatives, absorption promoters containing the derivatives as the effective ingredient and external preparation containing the absorption promoters
  申请人：HISAMITSU PHARMACEUTICAL CO., INC.

  公开号：EP0241050A2

  公开（公告）日：1987-10-14

  An azacycloalkane derivative useful for promoting the absorption of a medicine, an absorption promoting agent comprising at least one of the azacycloalkane derivatives as the effective ingredient for promoting the absorption and an external preparation containing the absorption promoting agent, the derivative being represented by the following formula wherein A is -CH2-or -S-for example, B is sulfur or oxygen, R is -SR" in which R" is an alkyl group or alkylthioalkyl group for example, or -OR" in which R" is as defined above, an alkyl group or substituted amino group, R' is a hydrogen atom, alkyl group or alkyloxy group for example, m is an integer of 0-5 and n is an integer of 1-15.

  一种用于促进药物吸收的氮杂环烷烃衍生物，一种包含至少一种氮杂环烷烃衍生物作为促进吸收有效成分的吸收促进剂，以及一种含有该吸收促进剂的外用制剂，该衍生物由下式表示 其中 A 是-CH2-或-S-例如，B 是硫或氧，R 是-SR"，其中 R "是烷基或烷硫烷基（例如），或-OR"，其中 R "如上定义，是烷基或取代的氨基，R'是氢原子、烷基或烷氧基（例如），m 是 0-5 的整数，n 是 1-15 的整数。
• IODOPROPARGYL DERIVATIVES AND ANTIMICROBIAL AGENTS CONTAINING THEM AS THE ACTIVE INGREDIENT
  申请人：NAGASE & COMPANY, LTD.

  公开号：EP0987244A1

  公开（公告）日：2000-03-22

  The present invention provides novel iodopropargyl derivatives represented by the following formula (1): wherein R1 is a methoxy group or a cyano group, which have a reduced unpleasant smell and also have a wide antimicrobial spectrum and a high antimicrobial activity. Also, the present invention provides antimicrobial, antifungal and preservative or antimold agents comprising the above derivatives as an active ingredient.

  本发明提供了由下式（1）表示的新型碘丙炔基衍生物： 其中 R1 为甲氧基或氰基，这些衍生物具有较低的难闻气味，同时具有较广的抗菌谱和较高的抗菌活性。此外，本发明还提供由上述衍生物作为活性成分的抗菌剂、防霉剂和防腐剂或防霉剂。
• ADHESIVE PATCH FOR EXTERNAL USE ON SKIN
  申请人：HISAMITSU PHARMACEUTICAL CO., INC.

  公开号：EP1676895A1

  公开（公告）日：2006-07-05

  A pressure-sensitive adhesive composition which comprises three ingredients, i.e., polyisoprene, a styrene/isoprene/styrene copolymer, and solid polyisobutylene, in a proportion of (10-60) / (10-50) / (20-60) by weight and further contains a non-solid isobutylene polymer and a tackifier, characterized in that the amount of the non-solid isobutylene polymer is 1 to 30 pts.wt., excluding 30 pts.wt., per 100 pts.wt. of the sum of the three ingredients, i.e., the polyisoprene, styrene/isoprene/styrene copolymer, and solid polyisobutylene. When used in an adhesive patch for external use on the skin, the composition has satisfactory tackiness regardless of whether the temperature of the surrounding air is high or low, has excellent long-term storage stability, retains the necessary cohesive force, and does not unnecessarily irritate the skin.

  一种压敏粘合剂组合物，它包括三种成分，即聚异丁烯、苯乙烯/异戊二烯/苯乙烯共聚物和固体聚异丁烯，其重量比例为(10-60)/(10-50)/(20-60)，并进一步含有非固体异丁烯聚合物和增粘剂，其特征在于，非固体异丁烯聚合物的量为 1 至 30 pts.wt、不包括三种成分（即聚异戊二烯、苯乙烯/异戊二烯/苯乙烯共聚物和固体聚异丁烯）之和每 100 pts.wt. 30 pts.wt.。当用于皮肤外用粘贴剂时，无论周围空气的温度是高是低，该组合物都具有令人满意的粘性，具有极佳的长期储存稳定性，保持必要的内聚力，并且不会对皮肤产生不必要的刺激。
• LOWLY IRRITATIVE ADHESIVE PATCH
  申请人：HISAMITSU PHARMACEUTICAL CO., INC.

  公开号：EP1666032A1

  公开（公告）日：2006-06-07

  An adhesive patch for external use which is significantly inhibited from causing a rash, is less irritative to the skin, and sufficiently retains adhesion to the skin. The adhesive patch is characterized by employing a pressure-sensitive adhesive base into which a sucrose fatty acid ester has been incorporated. It does not exert physical influences on the skin, such as stresses imposed on the skin during wear and upon peeling, while sufficiently retaining adhesion to the skin. It is significantly inhibited from causing a rash, and the skin irritation thereof has been minimized. This adhesive patch for external use has ideal, lowly irritative properties which have been impossible to any conventional adhesive patch for external use.

  一种外用胶贴，它能明显抑制皮疹的产生，对皮肤的刺激性较小，并能充分保持与皮肤的粘附性。这种贴片的特点是采用压敏型粘合剂基底，其中加入了蔗糖脂肪酸酯。它不会对皮肤产生物理影响，例如在佩戴和剥离时对皮肤施加的压力，同时还能充分保持与皮肤的粘附性。它对皮疹的抑制作用明显，对皮肤的刺激也降到了最低。这种外用胶贴具有理想的低刺激性，是任何传统外用胶贴所不具备的。