Oxosurinamensin | 68143-85-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Oxosurinamensin
• 英文别名: 2-[2-methoxy-4-[(E)-prop-1-enyl]phenoxy]-1-(3,4,5-trimethoxyphenyl)propan-1-one
• CAS: 68143-85-1
• 化学式: C₂₂H₂₆O₆
• 分子量: 386.445
• InChiKey: UWSPBGKTPVZWIB-BQYQJAHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  28
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  63.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Oxosurinamensin 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 反应 24.0h， 以101 mg的产率得到2-[2-methoxy-4-[(E)-prop-1-enyl]phenoxy]-1-(3,4,5-trimethoxyphenyl)propan-1-ol
  参考文献：
  名称：

  In Vitro Evaluation of Antifungal Properties of 8.O.4‘-Neolignans

  摘要：

  Eighteen racemic 8.O.4'-neolignans with six different substitution patterns in rings A and B, in their ketone and in their erythro and three alcoholic forms, were evaluated for antifungal activity by the agar dilution method. Only the alcohols exhibited a broad spectrum of activities against Microsporum canis, Microsporum gypseum, Tricophyton mentagrophytes, Tricophyton rubrum, and Epidermophyton floccosum. (+/-)-erythro-3,4-(methylenedioxy)-7-hydroxy-1'-allyl-3'5'-dimethoxy-8.O.4'-neolignan (11) was the most active compound in the series, and E. floccosum was the most susceptible species.

  DOI：

  10.1021/np9605504
• 作为产物：
  描述：

  3,4,5-三甲氧基苯甲醛 在 溴 作用下， 以 氯仿 为溶剂， 生成 Oxosurinamensin
  参考文献：
  名称：

  Neolignans of Virola surinamensis

  摘要：

  DOI：

  10.1016/s0031-9422(00)94227-4

文献信息

• Neolignans of Virola surinamensis
  作者：Lauro E.S. Barata、Paul M. Baker、Otto R. Gottlieb、Edmundo A. Rùveda

  DOI：10.1016/s0031-9422(00)94227-4

  日期：1978.1
• In Vitro Evaluation of Antifungal Properties of 8.O.4‘-Neolignans
  作者：Susana Zacchino、Gladis Rodríguez、Germán Pezzenati、Gabriela Orellana、Ricardo Enriz、Manuel Gonzalez Sierra

  DOI：10.1021/np9605504

  日期：1997.7.1

  Eighteen racemic 8.O.4'-neolignans with six different substitution patterns in rings A and B, in their ketone and in their erythro and three alcoholic forms, were evaluated for antifungal activity by the agar dilution method. Only the alcohols exhibited a broad spectrum of activities against Microsporum canis, Microsporum gypseum, Tricophyton mentagrophytes, Tricophyton rubrum, and Epidermophyton floccosum. (+/-)-erythro-3,4-(methylenedioxy)-7-hydroxy-1'-allyl-3'5'-dimethoxy-8.O.4'-neolignan (11) was the most active compound in the series, and E. floccosum was the most susceptible species.