A palladium catalyzed atom-efficient cross-coupling reactivity of triarylbismuths with α,β-unsaturated acyl chlorides
作者:Maddali L.N. Rao、Varadhachari Venkatesh、Deepak N. Jadhav
DOI:10.1016/j.jorganchem.2008.05.012
日期:2008.7
An atom-efficientcross-coupling reactivity of triarylbismuths (1 equiv) was demonstrated by cross-couplingreaction with 3 equiv of α,β-unsaturated acylchlorides under palladium catalysis in the synthesis of a series of functionalized α, β-unsaturated ketones in high isolated yields.
In an effort to develop new antimicrobial agents, a series of chalconederivatives, 3-60, were prepared by Claisen-Schmidt condensation of appropriate acetophenones and 2-furyl methyl ketones with appropriate aromatic aldehydes, furfural, and thiophene-2-carbaldehyde in an aqueous solution of NaOH and EtOH at room temperature. The synthesized compounds were characterized by means of their IR- and NMR-spectral
A New and Direct Synthesis of Chalcones Via TFAA-H3PO4 Mediated C-C Bond Forming Reaction
作者:Kavitha Kankanala、Lingam Venkata Reddy、Vangala Ranga Reddy、Khagga Mukkanti、Sarbani Pal
DOI:10.2174/157017811794557750
日期:2011.1.1
A number of α,β-unsaturated carboxylic acids were reacted with electron rich arenes or heteroarene in the presence of trifluoroacetic anhydride (TFAA) and H3PO4 at room temperature to give a variety of chalcone derivatives in good to excellent yields. The methodology was used to prepare novel compounds of potential pharmacological significances.
CBr<sub>4</sub> as a Halogen Bond Donor Catalyst for the Selective Activation of Benzaldehydes to Synthesize α,β-Unsaturated Ketones
作者:Imran Kazi、Somraj Guha、Govindasamy Sekar
DOI:10.1021/acs.orglett.7b00348
日期:2017.3.3
CBr4 has been employed as a halogen bond donor catalyst for the selective activation of aldehyde, to achieve an efficient solvent- and metal-free C═C bond forming reaction in the presence of strong acid sensitive groups such as methoxy, cyanide, ester, and ketal for the synthesis of α,β-unsaturated ketones. This unique capability of CBr4 to act as a halogen bond donor has been explored and established
Regioselective Synthesis of 1,3,5-Trisubstituted Pyrazoles
作者:Vidya G. Desai、Pooja C. Satardekar、Sampada Polo、Kashinath Dhumaskar
DOI:10.1080/00397911.2010.531492
日期:2012.3.15
Abstract A new and a simple approach toward synthesis of 1,3,5-trisubstitutedpyrazoles from chalcone arylhydrazones via oxidative cyclization has been achieved. 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone was successfully used as an oxidizing agent to give excellent yields of pyrazoles. GRAPHICAL ABSTRACT