rac-1,2-dioleoyl-3-N,N-dimethylaminopropane

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: rac-1,2-dioleoyl-3-N,N-dimethylaminopropane
• 英文别名: 1,2-dioleoyl-N,N-dimethyl-3-aminopropane；(9Z,29Z)-19-[(dimethylamino)methyl]octatriaconta-9,29-diene-18,21-dione
• 化学式: C₄₁H₇₇NO₂
• 分子量: 616.068
• InChiKey: FHRQPRSLYVZWMV-WRBBJXAJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.6
• 重原子数：
  44
• 可旋转键数：
  35
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  aqueous sodium chloride 、 草酰氯 、 油酸 、 3-二甲胺基-1,2-丙二醇 生成 rac-1,2-dioleoyl-3-N,N-dimethylaminopropane
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• CATIONIC LIPID
  申请人：NOF CORPORATION

  公开号：US20180155304A1

  公开（公告）日：2018-06-07

  The present invention aims to provide a cationic lipid that can be used as a nucleic acid delivery carrier, a lipid membrane structure using a cationic lipid, a nucleic acid-introducing agent using a cationic lipid, and a method of achieving nucleic acid introduction by using a nucleic acid-introducing agent containing a cationic lipid. A lipid membrane structure containing a cationic lipid represented by the formula (1) wherein each symbol is as defined in the DESCRIPTION, is superior in the stability in blood and tumor accumulation property. A nucleic acid-introducing agent using the cationic lipid can achieve high nucleic acid delivery efficiency of nucleic acid to be delivered into the cytoplasm.

  本发明旨在提供一种可用作核酸传递载体的阳离子脂质，使用阳离子脂质的脂质膜结构，使用阳离子脂质的核酸引入剂，以及通过使用含有阳离子脂质的核酸引入剂实现核酸引入的方法。含有由式（1）表示的阳离子脂质的脂质膜结构，在血液稳定性和肿瘤聚集性方面具有优越性。使用阳离子脂质的核酸引入剂可以实现将核酸高效传递到细胞质中。
• INTRAESOPHAGEAL ADMINISTRATION OF TARGETED NITROXIDE AGENTS FOR PROTECTION AGAINST IONIZING IRRADIATION-INDUCED ESOPHAGITIS
  申请人：University of Pittsburgh - Of the Commonwealth System of Higher Education

  公开号：US20190210969A1

  公开（公告）日：2019-07-11

  Provided herein are compositions and related methods useful for prevention or mitigation of ionizing radiation-induced esophagitis. The compositions comprise compounds comprising a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent or mitigate esophageal damage caused by radiation.

  本文提供了一种用于预防或缓解电离辐射诱导的食管炎的组合物和相关方法。这些组合物包括含有与线粒体靶向基团相连的亚硝基含有基团的化合物。这些化合物可以交联成二聚体而不丧失活性。该方法包括向患者输送本文所述的化合物，以有效预防或缓解由辐射引起的食道损伤。
• [EN] CATIONIC POLYMERS<br/>[FR] POLYMÈRES CATIONIQUES
  申请人：TRANSLATE BIO INC

  公开号：WO2019152802A1

  公开（公告）日：2019-08-08

  Disclosed are cationic polymers comprising monomers such as those described in Formula (I). Such polymers can be useful for the preparation of therapeutic compositions [e.g., compositions comprising nucleic acids such as m RNA). Additionally, therapeutic compositions comprising these cationic, biodegradable polymers can have improved properties and reduced toxicity.

  揭示了包括如公式(I)中所述单体的阳离子聚合物。这些聚合物可用于制备治疗性组合物（例如，包含核酸如mRNA的组合物）。此外，包含这些阳离子、可生物降解聚合物的治疗性组合物可能具有改善的性能和降低的毒性。
• NOVEL ION CHANNEL-FORMING PEPTIDES
  申请人：Yang Jerry

  公开号：US20110046020A1

  公开（公告）日：2011-02-24

  The invention pertains generally to novel compositions and methods for constructing chemically sensitive ion channels. The compositions and methods include, for example, novel gramicidin A derivatives and their use in constructing novel ion channels for use as biosensors.

  本发明涉及新型组合物和构建化学敏感离子通道的方法。该组合物和方法包括新型青霉素A衍生物及其在构建用作生物传感器的新型离子通道中的应用。
• NOVEL MULTIMODULAR ASSEMBLY USEFUL FOR INTRACELLULAR DELIVERY
  申请人：Pitard Bruno

  公开号：US20120058139A1

  公开（公告）日：2012-03-08

  A stabilized multimodular assembly for intracellular delivery comprising a complex of at least one cationic transfection agent and of at least one negatively charged macromolecule, wherein the complex has a theoretical charge ratio ranging from about 0 to about 4, and an efficient amount of at least one amphiphilic block co-polymer acting as a steric colloidal stabilizer with respect to the complex, the block co-polymer having hydrophilic and hydrophobic blocks wherein at least one hydrophilic block is conjugated with at least one targeting ligand.

  一种用于胞内递送的稳定的多模块组装体，包括至少一个阳离子转染剂和至少一个带负电荷的大分子的复合物，其中复合物的理论电荷比在大约0至4之间，以及至少一种有效量的两亲性嵌段共聚物作为对于复合物的立体胶体稳定剂，该嵌段共聚物具有亲水性和疏水性嵌段，其中至少一个亲水性嵌段与至少一个靶向配体结合。