2-氨基-3-苯基吡啶 | 87109-10-2

• 物质功能分类: 生物 - 细胞培养 - 添加剂
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-氨基-3-苯基吡啶
• 中文别名: 2-胺基-3-苯基吡啶；3-苯基-2-氨基吡啶
• 英文名称: 2-amino-3-phenyl pyridine
• 英文别名: 3-phenylpyridin-2-amine；3-Phenylpyridin-2-ylamine
• CAS: 87109-10-2
• 化学式: C₁₁H₁₀N₂
• mdl: MFCD04114119
• 分子量: 170.214
• InChiKey: OJXNUAWQULNUCP-UHFFFAOYSA-N

物化性质

• 沸点：
  320.3±22.0 °C(Predicted)
• 密度：
  1.133

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  38.9
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2933399090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335
• 储存条件：
  存储条件：2-8°C，避光、干燥密闭保存。

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 3-Phenyl-pyridin-2-ylamine
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: 3-Phenyl-pyridin-2-ylamine
CAS number: 87109-10-2

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C11H10N2
Molecular weight: 170.2

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  2-氨基-3-苯基吡啶 在 四丁基溴化铵 、 palladium diacetate 、 碳酸氢钠 、 potassium carbonate 、 4,5-双二苯基膦-9,9-二甲基氧杂蒽 作用下， 以 乙醇 、 N,N-二甲基乙酰胺 、 水 为溶剂， 反应 26.0h， 生成 3-phenyl-6H-benzo[b]imidazo[5,1,2-de]quinolizin-6-one
  参考文献：
  名称：

  通过C–H酰化和酰化作用的Pd催化串联环化反应，用于多环支架的构建

  摘要：

  提出了通过C–H芳基化和酰化反应，用2-氯苯甲醛将Pd催化的咪唑并[1,2- a ]吡啶串联环化反应，以有效合成新型6 H-苯并[ b ]咪唑并[5,1,2] -德〕喹6人。直接酰化反应在没有引导基团的帮助下并且在作为清洁和游离末端氧化剂的空气存在下顺利进行。

  DOI：

  10.1021/acs.orglett.6b02571
• 作为产物：
  描述：

  3-溴-2-氯吡啶 在 silver hexafluoroantimonate 、 四(三苯基膦)钯 、 bis(1,5-cyclooctadiene)diiridium(I) dichloride 、 hydrazine hydrate 、 potassium carbonate 、 溶剂黄146 、 sodium nitrite 作用下， 以 1,4-二氧六环 、 乙二醇二甲醚 、 水 、 苯 为溶剂， 反应 50.5h， 生成 2-氨基-3-苯基吡啶
  参考文献：
  名称：

  1,2,3,4-四唑通过电环化的 Ir 催化分子内环化/C(sp2)-H 胺化

  摘要：

  描述了一种对含有 C8 取代芳烃、杂芳烃和烯烃的 1,2,3,4-四唑进行分子内脱氮环化/C(sp2)-H 胺化的有效策略。该过程涉及通过 [Cp*IrCl2]2 和 AgSbF6 的组合从四唑生成金属-氮烯中间体。已经表明该反应通过前所未有的电环化过程进行。该方法已成功应用于合成各种 α-咔啉和 7-氮杂吲哚。

  DOI：

  10.1021/jacs.8b05343
• 作为试剂：
  描述：

  3-苯基吡啶 、 氨基钠 在 2-氨基-3-苯基吡啶 作用下， 以The 2-amino-3-phenylpyridine that is formed的产率得到2-氨基-3-苯基吡啶
  参考文献：
  名称：

  2,3-Dihydrocyclopenta[d]pyrido[1,2-a]pyrimidin-10(1H)-one and its

  摘要：

  提供了化学式为##SPC1##的化合物，可用作中枢神经系统抑制剂。

  公开号：

  US03965100A1

文献信息

• Synthesis and evaluation of the anticoccidial activity of trifluoropyrido[1,2-a]pyrimidin-2-one derivatives
  作者：Laurence Silpa、Alisson Niepceron、Fabrice Laurent、Fabien Brossier、Mélanie Pénichon、Cécile Enguehard-Gueiffier、Mohamed Abarbri、Anne Silvestre、Julien Petrignet

  DOI：10.1016/j.bmcl.2015.11.018

  日期：2016.1

  of our chemical library to discover new molecules exhibiting in vitro activity against the invasion of host cells by Eimeria tenella revealed a lead compound with an IC50 of 15μM. Structure-activity relationship studies were conducted with 34 newly synthesized compounds to identify more active molecules and enhance in vitro activity against the parasite. Four compounds were more effective in inhibiting

  筛选我们的化学文库以发现表现出抗艾美尔球虫侵袭宿主细胞的体外活性的新分子，发现了一种铅化合物，IC50为15μM。使用34种新合成的化合物进行了结构-活性关系研究，以鉴定更多活性分子并增强体外抗寄生虫活性。四种化合物在体外抑制MDBK细胞入侵方面比先导化合物更有效。
• PHYTOSANITARY COMPOSITIONS COMPRISING AN ETHER-AMIDE COMPOUND
  申请人：RHODIA OPERATIONS

  公开号：US20150208645A1

  公开（公告）日：2015-07-30

  The object of the present invention is phytosanitary compositions comprising an active phytosanitary product and an ether-amide compound. The ether-amide compound may natively be present as a solvent, co-solvent, crystallization inhibitor or an agent for increasing bioactivity of the active phytosanitary product.

  本发明的对象是包括活性植物保健产品和醚酰胺化合物的植物保健组合物。该醚酰胺化合物可以作为溶剂、共溶剂、结晶抑制剂或用于增加活性植物保健产品生物活性的剂。
• Pd-Catalyzed Suzuki coupling reactions of aryl halides containing basic nitrogen centers with arylboronic acids in water in the absence of added base
  作者：Zhao Li、Carol Gelbaum、Zachary S. Campbell、Paul C. Gould、Jason S. Fisk、Bruce Holden、Arvind Jaganathan、Gregory T. Whiteker、Pamela Pollet、Charles L. Liotta

  DOI：10.1039/c7nj03567e

  日期：——

  The Pd-catalyzed Suzuki coupling reactions of a series of aryl chlorides and aryl bromides containing basic nitrogen centers with arylboronic acids in water in the absence of added base are reported. The reactions proceed either partially or entirely under acidic conditions. After surveying twenty-two phosphorus ligands, high yields of products were obtained with aryl chlorides only when a bulky ligand

  据报道，在不添加碱的情况下，水中一系列含碱性氮中心的芳基氯化物和芳基溴化物与水中的芳基硼酸进行钯催化的Suzuki偶联反应。反应在酸性条件下部分或全部进行。在调查了二十二个磷配体后，只有在庞大的配体2-（二叔丁基-膦基）-1-苯基-1 H上，芳基氯化物才能获得高收率的产品。使用了吡咯（cataCXium®PtB）。相反，在不存在添加的碱和添加的配体的情况下，芳基溴化物产生高产率的产物。为了完全探索酸性条件下的Suzuki偶联过程，使用几种模型底物在缓冲的酸性介质中进行了一系列反应。在cataCXium®PtB的存在下，4-氯苄基胺在缓冲的pH 6.0下产生了高收率的产品；在缓冲pH 5.0和更低的条件下，产量急剧下降。产量的下降归因于Pd-配体络合物的分解，这是由于在较酸性的水性介质中配体的质子化所致。相反，在没有添加配体的情况下，4-氨基-2-氯吡啶在缓冲的pH 3.5和4下产生定量产率
• [EN] METHODS FOR EXTERNAL BASE-FREE SUZUKI COUPLINGS<br/>[FR] PROCÉDÉS DE COUPLAGE DE SUZUKI SANS BASE EXTERNE
  申请人：DOW GLOBAL TECHNOLOGIES LLC

  公开号：WO2017112576A1

  公开（公告）日：2017-06-29

  The present disclosure describes a method of coupling a first aromatic compound to a second aromatic compound, the method comprising: (a) preparing a reaction mixture comprising the first aromatic compound, the second aromatic compound, a catalyst and water; the reaction mixture does not contain an external base, the reaction mixture having an initial pH of from 11 to 1; the catalyst having at least one group 10 atom; the first aromatic compound having a halogen, triflate or sulfonate substituent; the second aromatic compound having a boron-containing substituent; wherein, at least one of the first aromatic compound or the second aromatic compound includes one or more heteroatom; and (b) reacting the first aromatic compound and the second aromatic compound in the reaction mixture, the reaction mixture having a final pH following reaction of the first aromatic compound and the second aromatic compound.

  本公开描述了一种将第一芳香化合物与第二芳香化合物耦合的方法，该方法包括：(a)制备一个反应混合物，包含第一芳香化合物、第二芳香化合物、催化剂和水；该反应混合物不含有外部碱，其具有从11到1的初始pH值；催化剂至少含有一个第10族元素原子；第一芳香化合物具有卤素、三氟甲磺酸盐或磺酸盐取代基；第二芳香化合物具有含硼取代基；其中，第一芳香化合物或第二芳香化合物中的至少一个包含一个或多个杂原子；以及(b)在反应混合物中使第一芳香化合物和第二芳香化合物反应，反应混合物在第一芳香化合物和第二芳香化合物反应后具有一个最终的pH值。
• Reagent Design and Ligand Evolution for the Development of a Mild Copper-Catalyzed Hydroxylation Reaction
  作者：Patrick S. Fier、Kevin M. Maloney

  DOI：10.1021/acs.orglett.7b01403

  日期：2017.6.2

  modular ligand library, high-throughput experimentation, and rational ligand evolution have led to a novel copper catalyst for the synthesis of phenols with a traceless hydroxide surrogate. The mild reaction conditions reported here enable the late-stage synthesis of numerous complex, druglike phenols.

  模块化配体库的并行合成和质量导向纯化，高通量实验和合理的配体演化，已经导致了一种新型的铜催化剂，可用于合成具有无痕氢氧化物的苯酚。此处报道的温和的反应条件使许多复杂的类药物酚的后期合成成为可能。