H-Ala-OH p-toluenesulfonic acid salt | 82819-30-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: H-Ala-OH p-toluenesulfonic acid salt
• 英文别名: DL-Alanine p-toluenesulfonate salt；DL-alanine p-toluenesulfonate；alanine p-toluenesulfonate；toluene-4-sulfonic acid ; DL-alanine-salt；Toluol-4-sulfonsaeure; DL-Alanin-Salz；2-Aminopropanoic acid;4-methylbenzenesulfonic acid
• CAS: 82819-30-5
• 化学式: C₃H₇NO₂*C₇H₈O₃S
• 分子量: 261.299
• InChiKey: INTPAHFQJIPREM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.66
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  126
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1,1'-羰基二(1H-苯并咪唑) 、 H-Ala-OH p-toluenesulfonic acid salt 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  Purygin, P. P., Journal of Organic Chemistry USSR (English Translation), 1985, vol. 21, # 4, p. 835 - 836

  摘要：

  DOI：
• 作为产物：
  描述：

  对甲苯磺酸 、 DL-丙氨酸 以 乙腈 为溶剂， 反应 1.5h， 以94%的产率得到H-Ala-OH p-toluenesulfonic acid salt
  参考文献：
  名称：

  Reagents and Synthetic Methods; 19. Synthesis ofN-(N-Aryl- orN-Alkylaminocarbonyl)-amino Acids by Addition ofN,O-Bis[trimethylsilyl]amino Acids to Isocyanates

  摘要：

  DOI：

  10.1055/s-1982-30060

文献信息

• [EN] COMPOSITIONS AND METHODS FOR ASSESSING EYE VASCULATURE<br/>[FR] COMPOSITIONS ET MÉTHODES POUR ÉVALUER LE SYSTÈME VASCULAIRE DE L'ŒIL
  申请人：MEDIBEACON INC

  公开号：WO2016183351A1

  公开（公告）日：2016-11-17

  The present disclosure relates to compositions and methods for assessing blood vessels and organs of the body, more specifically to methods for assessing the vasculature of the eye.

  本公开涉及用于评估人体血管和器官的组合物和方法，更具体地说是用于评估眼部血管的方法。
• α-Aminosulfonopeptides as possible functional analogs of penicillin; evidence for their extreme instability
  作者：Seunguk Paik、Emil H. White

  DOI：10.1016/0040-4020(96)00055-5

  日期：1996.4

  bearing an α-aminosulfonic acid moiety in the penultimate position have been synthesized using a Curtius rearrangement step. The sulfonopeptides were prepared and examined in aprotic solvents, but they proved to be exceedingly labile in protic solvents; for example, α-acylaminosulfonodipeptide 31 proved to be too unstable to isolate in pure form and its methyl ester, 34, decomposed with a half-life of ca

  已经使用Curtius重排步骤合成了在倒数第二个位置带有α-氨基磺酸部分的酰基-D-Ala-D-Ala的磺肽类似物。制备了磺肽并在质子惰性溶剂中进行了检测，但事实证明它们在质子惰性溶剂中极不稳定。例如，事实证明，α-酰基氨基磺基二肽31太不稳定，不能以纯净的形式分离出来，它的甲酯34的半衰期约为20。在pD = 5和25°C下于50％甲醇中放置8分钟。描述了与α-磺肽的稳定性有关的机理研究，包括对水溶液中分解产物的分析。
• Phosphoramidate Derivatives of Guanosine Nucleoside Compunds for Treatment of Viral Infections
  申请人：Chamberlain Stanley

  公开号：US20120052046A1

  公开（公告）日：2012-03-01

  Phosphoramidate compounds derived from guanine bases having enhanced therapeutic potency are provided, and these compounds in particular have enhanced potency with respect to treatment of viral infections, such as hepatitis C virus. Pharmaceutical compositions, methods of preparing the compounds, and methods of using the compounds and compositions to treat viral infections are also provided.

  本发明提供了从鸟嘌呤碱基衍生的磷酰胺化合物，具有增强的治疗效力，特别是对于治疗病毒感染，如丙型肝炎病毒，具有增强的效力。本发明还提供了制备该化合物的制药组合物、制备该化合物的方法以及使用该化合物和组合物治疗病毒感染的方法。
• MW‐Enhanced High‐Speed Deprotection of Boc Group Using<i>p</i>‐TsOH and Concommitant Formation of<i>N</i>‐Me‐Amino Acid Benzyl Ester<i>p</i>‐TsOH Salts
  作者：Vommina V. Suresh Babu、Basanagoud S. Patil、Ganga‐Ramu Vasanthakumar

  DOI：10.1081/scc-200063953

  日期：2005.7

  A high-speed, complete deprotection of Boc group from Boc amino acids and protected peptide esters employing p-TsOH in toluene under microwave irradiation is found to be complete in 30 s. The deprotection can be carried out in methanol and acetonitrile also. Under the present conditions, C-peptide benzyl esters and O-benzyl ethers have been found to be stable. This has permitted us to carry out the synthesis of [Leu] enkephalin employing the Boc/Bzl-group strategy. Further more, it has been found that both N-alpha-Fmoc and N-alpha-Z groups are completely stable. The present conditions can be extended for the concomitant removal of the Boc group and the formation of C-benzyl amino acid esters as well. This has been utilized for the synthesis of N-Me amino acid benzyl esters starting from Boc-N-Me amino acids in a single step.
• �ber die Einwirkung von aromatischen Sulfo- und Oxysulfos�uren auf ?- und ?-Aminos�uren
  作者：Guido Machek

  DOI：10.1007/bf01518107

  日期：1935.12