5,5-二乙氧基-1-戊胺 | 21938-23-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 5,5-二乙氧基-1-戊胺
• 英文名称: 5-Aminopentanal Diethyl Acetal
• 英文别名: 5-amino-1,1-diethoxypentane；4,4-diethoxypentan-1-amine；5,5-diethoxypentylamine；5,5-diethoxy-pentylamine；5-Amino-valeraldehyd-diaethylacetal；5,5-Diaethoxy-pentylamin；5,5-Diethoxypentan-1-amine
• CAS: 21938-23-8
• 化学式: C₉H₂₁NO₂
• mdl: MFCD18377868
• 分子量: 175.271
• InChiKey: RUNMJSMLSGFSBB-UHFFFAOYSA-N

物化性质

• 沸点：
  232℃
• 密度：
  0.904
• 闪点：
  101℃
• 溶解度：
  氯仿（微溶）、乙酸乙酯（微溶）

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  12
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  44.5
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2922199090

反应信息

• 作为反应物：
  描述：

  5,5-二乙氧基-1-戊胺 在 对甲苯磺酸 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 生成 2-Ethoxy-piperidine-1-carboxylic acid benzyl ester
  参考文献：
  名称：

  Solid-Phase Synthesis of Piperidines by N-Acyliminium Ion Chemistry

  摘要：

  An efficient solid-phase procedure for the synthesis of a number of 2-substituted piperidines is reported. Starting from solid-supported carbamate-tethered delta-amino acetals, 2-benzotriazolyl-substituted (Bt-substituted) piperidines were obtained by acid-induced ring-closure followed by trapping of the transient N-acyliminium ions with benzotriazole. These 2-Bt-substituted piperidines were then used as precursors for the successful introduction of several C-nucleophiles by N-acyliminium. ion chemistry. (C) Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.

  DOI：

  10.1002/1099-0690(200209)2002:18<3133::aid-ejoc3133>3.0.co;2-h
• 作为产物：
  描述：

  4-氯丁醛缩二乙醇 在 乙醇 、 sodium 、 乙二醇 、 potassium iodide 作用下， 生成 5,5-二乙氧基-1-戊胺
  参考文献：
  名称：

  Anet et al., Australian Journal of Scientific Research, Series A: Physical Sciences, 1950, vol. 3, p. 336,339

  摘要：

  DOI：

文献信息

• Triflic acid-mediated phenylation of N-acylaminoalkyl diethylacetals and N-acyl-2-phenyl cyclic amides
  作者：Frank D. King、Stephen Caddick

  DOI：10.1039/c0ob01149e

  日期：——

  The reaction of N-acylaminoalkyl diethylacetals with triflic acid in benzene gave N-acylamino-diphenylalkyls. The proposed intermediates are the N-acyl-2-phenyl cyclic amides, which themselves are similarly converted to N-acylamino-diphenylalkyls.

  N-酰基氨基烷基二乙缩醛与三氟甲磺酸 在 苯得到N-酰基氨基-二苯基烷基。所提出的中间体是N-酰基-2-苯基环状酰胺，其本身被类似地转化为N-酰基氨基-二苯基烷基。
• A facile synthesis of quinolizidines and indolizidines
  作者：Frank D. King

  DOI：10.1016/s0040-4039(00)88158-7

  日期：1983.1

  A biomimetic synthesis of quinolizidines and indolizidines via an intramolecular Mannich reaction is described.

  描述了通过分子内曼尼希反应的仿生合成喹喔啉和吲哚并核苷。
• MENTHYL CARBAMATE COMPOUNDS AS SKIN AND/OR HAIR LIGHTENING ACTIVES
  申请人：Vielhaber Gabriele

  公开号：US20130129646A1

  公开（公告）日：2013-05-23

  The present invention relates to the cosmetic, dermatological or pharmaceutical (therapeutic) use of compounds of formula (I) or a cosmetically acceptable salt of a compound of formula (I) or a mixture containing two or more of these compounds or the salts thereof wherein R 1 denotes hydrogen or an organic radical having 1 to 14 carbon atoms, R 2 denotes an organic radical having 1 to 14 carbon atoms, and wherein optionally R 1 and R 2 are covalently bonded to one another, preferably so that a 3 to 8 membered ring is formed, for the lightening of skin and/or hair. The invention further relates to compositions and cosmetic, dermatological or pharmaceutical preparations (compositions) comprising one or more compounds of formula (I) suitable for lightening human skin and/or hair and corresponding methods. The invention further relates to compounds of formula (I) as a drug, their use for the preparation of a pharmaceutical composition for lightening human skin and/or hair and to certain novel compounds of formula (I).

  本发明涉及化妆品、皮肤科或药用（治疗）用途的化合物的使用，其化学式为（I）或者化学式（I）的化妆品可接受的盐，或者含有两种或更多这些化合物或其盐的混合物，其中R1代表氢或具有1至14个碳原子的有机基，R2代表具有1至14个碳原子的有机基，可选地R1和R2彼此共价结合，最好形成3至8成员环，用于美白皮肤和/或头发。该发明还涉及包含一种或多种化学式（I）化合物的组合物和适用于美白人类皮肤和/或头发的化妆品、皮肤科或药用制剂（组合物）及相应的方法。该发明还涉及化学式（I）化合物作为药物，其用于制备用于美白人类皮肤和/或头发的药用组合物以及某些新的化学式（I）化合物。
• A simple one pot procedure for the generation of homoallylic alcohols from acetals and amino acetals
  作者：Adam McCluskey、Debra M Mayer、David J Young

  DOI：10.1016/s0040-4039(97)01106-4

  日期：1997.7

  Treatment of acetals (1 and 2) and amino acetals (3–5) with either trifluoroacetic acid (TFA) or silica gel followed by tetraallyltin gave excellent yields of the corresponding homoallylic alcohols (68 – 100%).

  用三氟乙酸（TFA）或硅胶，再用四烯丙基甘油处理乙缩醛（1和2）和氨基乙缩醛（3-5），得到相应的均烯丙基醇（68-100％），产率极高。
• A novel synthesis of (±)-harmacine and (±)1,2,3,4,6,7,12,12b-octahydroindole[2,3-a]quinolizine
  作者：Frank D. King

  DOI：10.1002/jhet.5570440634

  日期：2007.11

  A three-step synthesis of (±)-harmacine is described from the readily available 4,4-diethoxybutan-1-amine via an acid-mediated acyl iminium ion cyclisation. The synthesis of the homologous (±)1,2,3,4,6,7,12,12b-octahydroindole[2,3-a]quinolizine from 5,5-diethoxypentan-1-amine is also described. Although similar, the two systems required very different cyclisation conditions.

  从容易获得的4,4-二乙氧基丁烷-1-胺经酸介导的酰基亚胺离子环化反应，描述了（±）-甜菜碱的三步合成法。还描述了由5，5-二乙氧基戊丹-1-胺合成同源的（±）1,2,3,4,6,7,12,12b-八氢吲哚[2,3- a ]喹诺嗪。尽管相似，但这两个系统需要非常不同的环化条件。