3,5,4’-trihydroxy-6,7,3’- trimethoxyflavone | 578-71-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 3,5,4’-trihydroxy-6,7,3’- trimethoxyflavone
• 英文别名: 3,5,4′-trihydroxy-6,7,3′-trimethoxy-flavone；3,5,4'-trihydroxy-6,7,3'-trimethoxyflavone；veronicafolin；3,5-dihydroxy-2-(4-hydroxy-3-methoxy-phenyl)-6,7-dimethoxy-chromen-4-one；Chrysosplenetin；3,4',5-Trihydroxy-3',6,7-trimethoxyflavone；3,5-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-6,7-dimethoxychromen-4-one
• CAS: 578-71-2
• 化学式: C₁₈H₁₆O₈
• 分子量: 360.32
• InChiKey: RQJFJWHHIIPKGW-UHFFFAOYSA-N

物化性质

• 沸点：
  607.9±55.0 °C(Predicted)
• 密度：
  1.482±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  115
• 氢给体数：
  3
• 氢受体数：
  8

安全信息

• 海关编码：
  2914509090

反应信息

• 作为反应物：
  描述：

  3,5,4’-trihydroxy-6,7,3’- trimethoxyflavone 生成 [4-(3,5-diacetyloxy-6,7-dimethoxy-4-oxochromen-2-yl)-2-methoxyphenyl] acetate
  参考文献：
  名称：

  HORIE, TOKUNARU;KAWAMURA, YASUHIKO;TSUKAYAMA, MASAO;YOSHIZAKI, SHIRO, CHEM. AND PHARM. BULL., 37,(1989) N, C. 1216-1220

  摘要：

  DOI：
• 作为产物：
  描述：

  4-(benzyloxy)-3-methoxybenzoic anhydride 在 palladium on activated charcoal aluminum tri-bromide 、 氢气 、 Potassium benzoate 、 potassium carbonate 作用下， 以 甲醇 、 乙酸乙酯 、 丙酮 、 乙腈 为溶剂， 反应 13.83h， 生成 3,5,4’-trihydroxy-6,7,3’- trimethoxyflavone
  参考文献：
  名称：

  Horie, Tokunaru; Kawamura, Yasuhiko; Tsukayama, Masao, Chemical and pharmaceutical bulletin, 1989, vol. 37, # 5, p. 1216 - 1220

  摘要：

  DOI：

文献信息

• [EN] COMPOUNDS FOR TREATING EYE DISEASES AND DISORDERS<br/>[FR] COMPOSÉS POUR LE TRAITEMENT DE MALADIES ET DE TROUBLES OCULAIRES
  申请人：THE STATE OF ISRAEL MINISTRY OF AGRICULTURE & RURAL DEVELOPMENT AGRICULTURAL RES ORGANIZATION ARO VO

  公开号：WO2022123573A1

  公开（公告）日：2022-06-16

  The invention concerns 3,5,4'-trihydroxy-6,7,3'-trimethoxyflavone (TTF) or a pharmaceutically acceptable salt or solvate thereof for use in treating, preventing, or ameliorating an eye disease or disorder, or for providing adjunct treatment to an ocular therapeutic procedure. The invention also concerns ophthalmic compositions comprising TTF.

  本发明涉及3,5,4'-三羟基-6,7,3'-三甲氧基黄酮（TTF）或其药学上可接受的盐或溶剂的用途，用于治疗、预防或缓解眼部疾病或紊乱，或为眼部治疗程序提供辅助治疗。本发明还涉及含有TTF的眼科组合物。
• Flavonol 3-O-robinobiosides and 3-O-(2″-O-α-rhamnopyranosyl)-robinobiosides from Sesuvium portulacastrum
  作者：Wannaporn Disadee、Chulabhorn Mahidol、Poolsak Sahakitpichan、Somkit Sitthimonchai、Somsak Ruchirawat、Tripetch Kanchanapoom

  DOI：10.1016/j.tet.2011.04.041

  日期：2011.6

  Six new flavonol 3-O-robinobiosides and 3-O-(2 ''-O-alpha-L-rhamnopyranosyl)-robinobiosides, sesuviosides A F, were isolated from the aerial portion of Sesuvium portulacastrum together with ecdysterone, adenosine, 2'-O-methyladenosine, and L-tryptophan. The structure elucidations were based on analyses of chemical and spectroscopic data including 1D and 2D-NMR. Sesuviosides A-F and their aglycones exhibited radical scavenging activity using DPPH and ORAC assays. (C) 2011 Elsevier Ltd. All rights reserved.
• ANTI-NEUROINFLAMMATORY AND PROTECTIVE COMPOUNDS IN ACHILLEA FRAGRANTISSIMA
  申请人：The State of Israel - Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center)

  公开号：EP3074029A1

  公开（公告）日：2016-10-05
• [EN] ANTI-NEUROINFLAMMATORY AND PROTECTIVE COMPOUNDS IN ACHILLEA FRAGRANTISSIMA<br/>[FR] COMPOSÉS ANTINEURO-INFLAMMATOIRES ET PROTECTEURS DANS ACHILLEA FRAGANTISSIMA
  申请人：ISRAEL STATE

  公开号：WO2015079390A1

  公开（公告）日：2015-06-04

  The invention relates to 3,5,4'-trihydroxy-6,7,3'-trimethoxyflavone (T I F) and achillolid A in prevention or treatment of Alzheimer's disease as well as other neurodegenerative diseases such as Parkinson's disease, Amyotrophic Lateral Sclerosis (ALS), ischemia, immunodeficiency virus-1 (HTV-l)-associated dementia, Lewy body associated dementia, traumatic brain injury (TBI), glioma, epilepsy, Huntington's disease, multiple sclerosis, glaucoma and schizophrenia where neuroinflammation, oxidative stress, glutamate toxicity and amyloid beta toxicity are part of the pathophysiology.