6′-α-D-glucosylleucrose

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6′-α-D-glucosylleucrose
• 英文别名: Glc(a1-6)Glc(a1-5)Fru；(3S,4S,5R)-2-(hydroxymethyl)-5-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxyoxane-2,3,4-triol
• 化学式: C₁₈H₃₂O₁₆
• 分子量: 504.442
• InChiKey: JIOORPIMDXSDRJ-MJNMIMQHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.6
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  269
• 氢给体数：
  11
• 氢受体数：
  16

反应信息

• 作为产物：
  描述：

  蔗糖 在 Lactobacillus reuteri 121 reuteransucrase 作用下， 以 aq. acetate buffer 为溶剂， 反应 72.0h， 生成 可溶性淀粉 、 α-D-Glcp-(1→4)-α-D-Glcp-(1→4)-α-D-Glcp-(1↔2)-β-D-Fruf 、 α-D-Glcp-(1→6)-α-D-Glcp-(1→4)-α-D-Glcp-(1→4)-α-D-Glcp-(1↔2)-β-D-Fruf 、 6′-α-D-glucosylleucrose 、 4′-α-D-glucosylleucrose 、 、 、 、 α-D-Glcp-(1→6)-α-D-Glcp-(1→4)-α-D-Glcp-(1→6)-α-D-Glcp-(1→4)-α-D-Glcp-(1→4)-α-D-Glcp-(1↔2)-β-D-Fruf
  参考文献：
  名称：

  Synthesis of oligo- and polysaccharides by Lactobacillus reuteri 121 reuteransucrase at high concentrations of sucrose

  摘要：

  GTFA, a glucansucrase enzyme of the probiotic bacterium Lactobacillus reuteri 121, is capable of synthesizing an alpha-glucan polysaccharide with (1/4) and (1/6) linkages from sucrose. With respect to its biosynthesis, the present study has shown that the ratio of oligosaccharide versus polysaccharide synthesized was directly proportional to the concentration of sucrose. It appears that the size distribution of products is kinetically controlled, but the linkage distribution in the polysaccharide material is not changed. At high sucrose concentrations the sucrose isomers leucrose and trehalulose were synthesized, using the accumulated fructose as acceptor, together with 4'- and 6'-alpha-D-glucosyl-leucrose and 6'-alpha-D-glucosyl-trehalulose. The finding of an additional branched hexasaccharide demonstrates that the enzyme is able to introduce branch-points already in relatively short oligosaccharides. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2015.07.011

文献信息

• Synthesis of oligo- and polysaccharides by Lactobacillus reuteri 121 reuteransucrase at high concentrations of sucrose
  作者：Xiangfeng Meng、Justyna M. Dobruchowska、Gerrit J. Gerwig、Johannis P. Kamerling、Lubbert Dijkhuizen

  DOI：10.1016/j.carres.2015.07.011

  日期：2015.9

  GTFA, a glucansucrase enzyme of the probiotic bacterium Lactobacillus reuteri 121, is capable of synthesizing an alpha-glucan polysaccharide with (1/4) and (1/6) linkages from sucrose. With respect to its biosynthesis, the present study has shown that the ratio of oligosaccharide versus polysaccharide synthesized was directly proportional to the concentration of sucrose. It appears that the size distribution of products is kinetically controlled, but the linkage distribution in the polysaccharide material is not changed. At high sucrose concentrations the sucrose isomers leucrose and trehalulose were synthesized, using the accumulated fructose as acceptor, together with 4'- and 6'-alpha-D-glucosyl-leucrose and 6'-alpha-D-glucosyl-trehalulose. The finding of an additional branched hexasaccharide demonstrates that the enzyme is able to introduce branch-points already in relatively short oligosaccharides. (C) 2015 Elsevier Ltd. All rights reserved.