1,1,2-三氯-2-乙氧基乙烷 | 687-44-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1,1,2-三氯-2-乙氧基乙烷
• 英文名称: 1,1,2-trichloro-2-ethoxy-ethane
• 英文别名: 1,2,2-Trichlor-diethylether；ethyl-(1,2,2-trichloro-ethyl)-ether；1-Aethoxy-1,2,2-trichlor-aethan；Aethyl-(1,2,2-trichlor-aethyl)-aether；Aethyl-(α.β.β-trichlor-aethyl)-aether；α.β.β-Trichlor-(α-aethoxy)-aethan；α.β.β-Trichlor-diaethylaether；Trichloraether；1,1,2-Trichloro-2-ethoxyethane
• CAS: 687-44-5
• 化学式: C₄H₇Cl₃O
• 分子量: 177.458
• InChiKey: AHWDYEVOZYQTRK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1,1,2-三氯-2-乙氧基乙烷 在 mercury(II) fluoride 作用下， 生成 1-(三氟甲基)-1-环己烯
  参考文献：
  名称：

  Preparation and Properties of Some α-Fluoroethers^1,2

  摘要：

  DOI：

  10.1021/ja01589a052
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氯 作用下， 生成 1,1,2-三氯-2-乙氧基乙烷
  参考文献：
  名称：

  Godefroy, Jahresbericht ueber die Fortschritte der Chemie und Verwandter Theile Anderer Wissenschaften, 1886, p. 1173

  摘要：

  DOI：

文献信息

• Synthesis, Acidity Constants and Tautomeric Structure of 7-Arylhydrazono[1,2,4]Triazolo[3,4-b][1,3,4]thiadiazines in Ground and Excited States
  作者：Ahmad S. Shawali、Ibrahim F. Zeid、Mahmoud H. Abdelkader、Alsayed A. Elsherbini、Farag M. A. Altalbawy

  DOI：10.1002/jccs.200100012

  日期：2001.2

  7-Arylhydrazono[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines 4 were synthesized from the reactions of 4-amino-5-phenyl-4H-[1,2,4]triazole-3-thiol 2 and 2-(2-naphthyl)-2-oxoethanehydrazonoyl bromides 1 and their acid dissociation constants pK and pK*, in the ground and excited states, respectively, were determined. Both pK and pK* constants were correlated by Hammett equation. The pK and the spectral data

  7-芳基肼[1,2,4]三唑并[3,4-b][1,3,4]噻二嗪4由4-氨基-5-苯基-4H-[1,2,4]反应合成分别测定了三唑-3-硫醇 2 和 2-(2-萘基)-2-氧代乙烷腙酰溴 1 及其酸解离常数 pK 和 pK*，分别处于基态和激发态。pK 和 pK* 常数都通过 Hammett 方程相关。提供的 pK 和光谱数据表明标题化合物主要以腙互变异构形式存在。
• Effect of Long-Term Exposure to Fluoride in Drinking Water on Risks of Bone Fractures
  作者：Yiming Li、Chaoke Liang、Charles W. Slemenda、Rongdi Ji、Shuzhuang Sun、Jingxiang Cao、Christine L. Emsley、Feng Ma、Yunpeng Wu、Po Ying、Yan Zhang、Sujuan Gao、Wu Zhang、Barry P. Katz、Shiru Niu、Shouren Cao、Conrad C. Johnston

  DOI：10.1359/jbmr.2001.16.5.932

  日期：——

  Findings on the risk of bone fractures associated with long‐term fluoride exposure from drinking water have been contradictory. The purpose of this study was to determine the prevalence of bone fracture, including hip fracture, in six Chinese populations with water fluoride concentrations ranging from 0.25 to 7.97 parts per million (ppm). A total of 8266 male and female subjects ≥50 years of age were enrolled. Parameters evaluated included fluoride exposure, prevalence of bone fractures, demographics, medical history, physical activity, cigarette smoking, and alcohol consumption. The results confirmed that drinking water was the only major source of fluoride exposure in the study populations. A U‐shaped pattern was detected for the relationship between the prevalence of bone fracture and water fluoride level. The prevalence of overall bone fracture was lowest in the population of 1.00‐1.06 ppm fluoride in drinking water, which was significantly lower (p < 0.05) than that of the groups exposed to water fluoride levels ≥4.32 and ≤0.34 ppm. The prevalence of hip fractures was highest in the group with the highest water fluoride (4.32‐7.97 ppm). The value is significantly higher than the population with 1.00‐1.06 ppm water fluoride, which had the lowest prevalence rate. It is concluded that long‐term fluoride exposure from drinking water containing ≥4.32 ppm increases the risk of overall fractures as well as hip fractures. Water fluoride levels at 1.00‐1.06 ppm decrease the risk of overall fractures relative to negligible fluoride in water; however, there does not appear to be similar protective benefits for the risk of hip fractures.

  关于长期饮用水氟暴露与骨骨折风险之间关系的研究结果一直存在矛盾。本研究的目的是确定中国六个人群中骨骨折（包括髋部骨折）的普遍性，这些人群的饮用水氟浓度从0.25到7.97 ppm不等。共有8266名年龄≥50岁的男性和女性被纳入研究。评估的参数包括氟暴露、骨骨折的普遍性、人口统计学、病史、体力活动、吸烟和饮酒。结果证实，饮用水是研究人群中氟暴露的唯一主要来源。骨骨折普遍性与饮用水氟水平之间的关系呈现U型模式。总体骨骨折的普遍性在饮用水氟浓度为1.00-1.06 ppm的人群中最低，显著低于暴露于饮用水氟浓度≥4.32 ppm和≤0.34 ppm的人群（p < 0.05）。髋部骨折的普遍性在饮用水氟浓度最高（4.32-7.97 ppm）的人群中最高。这一数值显著高于饮用水氟浓度为1.00-1.06 ppm的人群，该人群中髋部骨折的普遍性最低。结论是，长期饮用含氟≥4.32 ppm的水会增加总体骨折和髋部骨折的风险。饮用水氟浓度为1.00-1.06 ppm时，相对于水中几乎不含氟的情况，降低了总体骨折的风险；然而，对于髋部骨折的风险，似乎没有类似的保护作用。
• Jacobsen, Chemische Berichte, 1871, vol. 4, p. 217
  作者：Jacobsen

  DOI：——

  日期：——
• Oddo; Mameli, Gazzetta Chimica Italiana, 1903, vol. 33 II, p. 402
  作者：Oddo、Mameli

  DOI：——

  日期：——
• Oddo; Mameli, Gazzetta Chimica Italiana, 1903, vol. 33 II, p. 411
  作者：Oddo、Mameli

  DOI：——

  日期：——