octakis-(2,6-di-O-methyl)-γ-cyclodextrin | 78828-92-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: octakis-(2,6-di-O-methyl)-γ-cyclodextrin
• 英文别名: octakis(2,6-di-O-methyl)cyclomalto-octaose；octakis(2,6-di-O-methyl)cyclomaltooctaose；octakis(2,6-di-O-methyl)cyclomaltoctaose
• CAS: 78828-92-9
• 化学式: C₆₄H₁₁₂O₄₀
• 分子量: 1521.57
• InChiKey: FGIHMPRHVNMLBF-UOILSBOQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.94
• 重原子数：
  104.0
• 可旋转键数：
  24.0
• 环数：
  30.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  457.2
• 氢给体数：
  8.0
• 氢受体数：
  40.0

反应信息

• 作为产物：
  描述：

  octakis(3-O-benzyl-2,6-di-O-methyl)cyclomaltooctaose 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 、 溶剂黄146 为溶剂， 以92%的产率得到octakis-(2,6-di-O-methyl)-γ-cyclodextrin
  参考文献：
  名称：

  A convenient preparation of per-2,6-di-O-methylcyclomalto-oligosaccharides

  摘要：

  DOI：

  10.1016/0008-6215(90)84214-f

文献信息

• Isolation and characterization of hexakis(2,6-di-O-methyl)cyclomaltohexaose and octakis(2,6-di-O-methyl)cyclomalto-octaose, and their over-methylated homologues.
  作者：Toshiko TANIMOTO(nee UTAMURA)、Yoko KUBOTA、Noriko NAKANISHI、Kyoko KOIZUMI

  DOI：10.1248/cpb.38.318

  日期：——

  The methylation of cyclomaltohexaose (α-CD) and cyclomalto-octaose (γ-CD) gave two major components in each case. These methylated compounds were isolated by high-performance liquid chromatography and characterized by carbon-13 unclear magnetic resonance spectroscopy, fast-atom bombardment mass spectrometry, and fragmentation analysis. The two major products from α-CD were hexakis(2, 6-di-O-methyl)cyclomaltohexaose and pentakis(2, 6-di-O-methyl)-mono(2, 3, 6-tri-O-methyl)cyclomaltohexaose and those from γ-CD were octakis(2, 6-di-O methyl)cyclomalto-octaose and heptakis(2, 6-di-O-methyl)-mono(2, 3, 6-tri-O-methyl)cyclomalto-octaose.

  环状麦芽六糖（α-CD）和环状麦芽八糖（γ-CD）的甲基化分别产生了两种主要成分。这些甲基化化合物通过高效液相色谱法分离，并通过碳-13不清晰磁共振波谱、快速原子轰击质谱和碎片分析进行表征。α-CD产生的两种主要产物是六（2,6-二-O-甲基）环状麦芽六糖和五（2,6-二-O-甲基）-单（2,3,6-三-O-甲基）环状麦芽六糖，γ-CD产生的两种主要产物是八（2,6-二-O-甲基）环状麦芽八糖和七（2,6-二-O-甲基）-单（2,3,6-三-O-甲基）环状麦芽八糖。
• Armspach, Dominique; Ashton, Peter R.; Ballardini, Roberto, Chemistry - A European Journal, 1995, vol. 1, # 1, p. 33 - 55
  作者：Armspach, Dominique、Ashton, Peter R.、Ballardini, Roberto、Balzani, Vincenzo、Godi, Anna、et al.

  DOI：——

  日期：——
• A sensitive and specific enzyme immunoassay for the detection of methyl ether derivatives of cyclomaltoheptaose
  作者：Florence Djedaı̈ni-Pilard、Marie-Claire Nevers、Sandrine Weisse、Jacques Grassi、Bruno Perly、Christophe Créminon

  DOI：10.1016/s0008-6215(03)00311-2

  日期：2003.9

  We have raised antibodies against two methylated derivatives of beta-CD, heptakis(2,6-di-O-methyl)cyclomaltoheptaose (Dimeb) and heptakis(2,3,6-tri-O-methyl)cyclomaltoheptaose (Trimeb). These antibodies were used to develop two specific and sensitive enzyme immunoassays, presenting a detection limit close to 500 and 30 pg/mL for Trimeb and Dimeb, respectively. Cross reactivities of different linear and cyclic maltooligosaccharides were investigated, demonstrating a high specificity against the structural features of the secondary hydroxyls rim. Several commercial Dimeb samples, containing different mixtures of partially methylated beta-cyclodextrin derivatives including RAMEB, which contains only a few amount of pure Dimeb, could be easily evaluated by the Dimeb immunoassay. Both of these assays have been shown to allow accurate measurement in plasma and urine, thus appearing as useful tools for further applications in biological material. (C) 2003 Elsevier Ltd. All rights reserved.