4-[2-(4-羟基苯基)丙烷-2-基]-2-甲基苯酚 | 14151-63-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-[2-(4-羟基苯基)丙烷-2-基]-2-甲基苯酚
• 英文名称: 2-(4-hydroxy-3-methylphenyl)-2-(4'-hydroxyphenyl)propane
• 英文别名: 2-Methyl-4.4'-isopropyliden-bisphenol；2-(3-methyl-4-hydroxyphenyl)-2-(4-hydroxyphenyl)propane；4-[2-(4-Hydroxyphenyl)propan-2-yl]-2-methylphenol
• CAS: 14151-63-4
• 化学式: C₁₆H₁₈O₂
• 分子量: 242.318
• InChiKey: HFRAJYYHALXFLZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 储存条件：
  室温

反应信息

• 作为反应物：
  描述：

  4-[2-(4-羟基苯基)丙烷-2-基]-2-甲基苯酚 、 potassium carbonate 、 4,4'-二氟二苯甲酮 、 甲苯 以 N,N-二甲基乙酰胺 为溶剂， 生成 methybisphenol-A benzophenone
  参考文献：
  名称：

  Electrophotographic photoconductors comprising polaryl ethers

  摘要：

  光电导体包括基板和至少一层。至少一层选自以下组中的一种：包括电荷转移分子、聚碳酸酯和第一种聚芳基醚的电荷转移层，所述第一种聚芳基醚选自聚芳基醚酮、聚(芳基-全氟芳基醚)、聚芳基醚酮-肼类、聚芳基醚酮-偶氮类及其混合物和共聚物；包括颜料、聚醇酸酯和第二种聚芳基醚的电荷生成层，所述第二种聚芳基醚选自聚芳基醚酮、聚芳基醚砜及其混合物和共聚物，以及它们的混合物。

  公开号：

  US06232025B1
• 作为产物：
  描述：

  对羟基苯甲酸甲酯 在 硫酸 作用下， 以 四氢呋喃 为溶剂， 生成 4-[2-(4-羟基苯基)丙烷-2-基]-2-甲基苯酚
  参考文献：
  名称：

  Structure–activity relationships of bisphenol A analogs at estrogen receptors (ERs): Discovery of an ERα-selective antagonist

  摘要：

  Our multi-template approach for drug discovery, focusing on protein targets with similar fold structures, has yielded lead compounds for various targets. We have also shown that a diphenylmethane skeleton can serve as a surrogate for a steroid skeleton. Here, on the basis of those ideas, we hypothesized that the diphenylmethane derivative bisphenol A (BPA) would bind to the ligand-binding domain of estrogen receptors (ERs) in a similar manner to estradiol and act as a steroid surrogate. To test this idea, we synthesized a series of BPA analogs and evaluated their structure-activity relationships, focusing on agonistic/antagonistic activities at ERs and ER alpha/ER beta subtype selectivity. Among the compounds examined, 18 was found to be a potent ER alpha-antagonist with high selectivity over ER beta and androgen receptor under our assay conditions. A computational docking study suggested that 18 would bind to the antagonistic conformation of ER alpha. ER alpha-selective antagonists, such as 18, are candidate agents for treatment of breast cancer. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.05.067

文献信息

• Fluorine-Containing Aromatic Compound and Method for Producing Same
  申请人：Nakatsuji Junya

  公开号：US20140194655A1

  公开（公告）日：2014-07-10

  Disclosed is a fluorine-containing aromatic compound represented by the following general formula (1) and its production method. In the formula (1), R 1 is a hydroxyl group or amino group, each of R 2 to R 5 is independently a hydrogen atom, or a C 1-4 straight chain or a C 3 or C 4 branched chain alkyl group, hydrogen atoms of the alkyl group may partially or totally be replaced with fluorine atoms, n is an integer of 0 to 2, and each of m and l is independently 0 or 1. A polymer derived from this fluorine-containing aromatic compound contains —C(CF 3 ) 2 OH group at a position away from the polymer main chain. Therefore, it is useful for resist use.

  揭示了一种含氟芳香化合物，其通式如下（1），以及其生产方法。在式（1）中，R1是羟基或氨基，R2至R5中的每一个独立地是氢原子，或者是C1-4直链或C3或C4支链烷基基团，烷基基团的氢原子可以部分或完全被氟原子取代，n是0到2的整数，m和l中的每一个独立地是0或1。从这种含氟芳香化合物衍生的聚合物在远离聚合物主链的位置含有—C(CF3)2OH基团。因此，它适用于抗蚀用途。
• Phosphazenium salt phase transfer catalysts
  申请人：Brunelle Joseph Daniel

  公开号：US20060069291A1

  公开（公告）日：2006-03-30

  A method for carrying out a chemical reaction between at least two reactants occupying separate phases within a multiphase reaction mixture has been discovered in which at least one phosphazenium salt is employed as a phase transfer catalyst. The remarkable utility of phosphazenium salts as phase transfer catalysts is illustrated by the preparation of aromatic ethers. The phosphazenium salt phase transfer catalysts are shown to be especially useful in the preparation of aromatic polyethers such as polyether sulfones.

  已经发现了一种在多相反应混合物中进行至少两种占据不同相位的反应物之间的化学反应的方法，其中至少一种磷氮盐被用作相转移催化剂。磷氮盐作为相转移催化剂的显著实用性可通过芳香醚的制备来说明。磷氮盐相转移催化剂在芳香聚醚如聚醚砜的制备中被证明特别有用。
• Study on the transesterification and mechanism of bisphenol A and dimethyl carbonate catalyzed by organotin oxide
  作者：Yanan Liang、Kunmei Su、Lei Cao、Yuan Gao、Zhenhuan Li

  DOI：10.1007/s11696-019-00759-0

  日期：2019.9

  were successfully synthesized for the transesterification of DMC with BPA. The products of mono-methylcarbonate-ended-BPA (MmC(1)) and two-methylcarbonate-ended-BPA (DmC(1)) were selectively synthesized over them. The catalysts were characterized by FT-IR, TG and XPS. When Ph2SnO was used as the catalyst at 170 °C, the BPA conversion reached to 28.60% and the transesterification selectivity reached

  成功地合成了（CF 3 C 6 H 4）2 SnO，（CH 3 C 6 H 4）2 SnO和Ph 2 SnO用于DMC与BPA的酯交换反应。在其上选择性地合成了单碳酸酯封端的BPA（MmC（1））和两碳酸酯封端的BPA（DmC（1））的产物。通过FT-IR，TG和XPS对催化剂进行了表征。当在170°C下使用Ph 2 SnO作为催化剂时，BPA转化率达到28.60％，酯交换选择性达到98.35％。至于（CF 3 C 6 H 4）2SnO，BPA转化率和酯交换选择性分别降至12.48％和64.74％。与（CF 3 C 6 H 4）2 SnO相比，BPA转化率增加到42.83％，但酯交换选择性下降到44.55％。值得注意的是，Ph 2 SnO的较高的酯交换选择性是由于其最低的Sn 4+电子结合能。更重要的是，DMC在（CF 3 C 6 H 4）2 SnO，（CH 3 C 6 H 4）2 SnO和Ph
• Polycarbonate compositions having improved barrier properties
  申请人：General Electric Company

  公开号：US04304899A1

  公开（公告）日：1981-12-08

  Polycarbonate compositions having improved barrier properties; i.e., low water vapor transmission and low gas permeability, are obtained by employing selected mono- and di-alkyl substituted monomers.

  采用特选的单烷基和双烷基取代单体，可以获得具有改进屏障性能的聚碳酸酯组合物，即低水蒸气透过率和低气体渗透性。
• Phoshazenium salt phase transfer catalysts
  申请人：Brunelle Joseph Daniel

  公开号：US20070112223A1

  公开（公告）日：2007-05-17

  A method for carrying out a chemical reaction between at least two reactants occupying separate phases within a multiphase reaction mixture has been discovered in which at least one phosphazenium salt is employed as a phase transfer catalyst. The remarkable utility of phosphazenium salts as phase transfer catalysts is illustrated by the preparation of aromatic ethers. The phosphazenium salt phase transfer catalysts are shown to be especially useful in the preparation of aromatic polyethers such as polyether sulfones.

  一种用于在多相反应混合物中进行至少两种占据不同相的反应物之间的化学反应的方法已被发现，其中至少使用一种磷氮盐作为相转移催化剂。磷氮盐作为相转移催化剂的显著实用性通过芳香醚的制备得到了说明。磷氮盐相转移催化剂在芳香族聚醚的制备中尤其有用，例如聚醚砜的制备。