quercetin-3-O-(6''-O-α-L-rhamnopyranosyl)-β-D-glucoside

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: quercetin-3-O-(6''-O-α-L-rhamnopyranosyl)-β-D-glucoside
• 英文别名: quercetin 3-rutinoside；2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one
• 化学式: C₂₇H₃₀O₁₆
• 分子量: 610.526
• InChiKey: IKGXIBQEEMLURG-LOOCNDHYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  43
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  266
• 氢给体数：
  10
• 氢受体数：
  16

反应信息

• 作为反应物：
  描述：

  quercetin-3-O-(6''-O-α-L-rhamnopyranosyl)-β-D-glucoside 在 盐酸 、 水 、 溶剂黄146 作用下， 生成 O2,O3,O4-trimethyl-L-6-deoxy-mannose 、 3-羟基-3,4,5,7-四甲氧基黄酮
  参考文献：
  名称：

  Khatoon; Khabiruddin; Asif, Journal of the Indian Chemical Society, 1989, vol. 66, # 4, p. 287 - 288

  摘要：

  DOI：

文献信息

• Formulations of tocopherols and methods of making and using them
  申请人：——

  公开号：US20030022818A1

  公开（公告）日：2003-01-30

  Non-naturally-occuring compositions for use in amelioration of disruption of energy metabolism secondary to stress are described. The compositions comprise a tocopherol and/or a derivative thereof, and a synergist, and are particularly suited for use as nutritional supplements. Synergists include, but are not limited to, flavonoids and lactoferrin and/or derivatives thereof. Compositions comprising an optimized formulation comprising a tocopherol and an additional compound such as daidzein or biochanin A are also described. Methods of making these compositions and methods of ameliorating injury(ies) or disruption of energy metabolism secondary to stress, comprising administering such compositions, are also disclosed.

  本文描述了用于缓解由压力引起的能量代谢紊乱的非自然组合物。该组合物包括生育酚和/或其衍生物以及协同剂，并特别适用于用作营养补充剂。协同剂包括但不限于类黄酮和乳铁蛋白及/或其衍生物。本文还描述了包括生育酚和daidzein或biochanin A等额外化合物的优化配方的组合物。本文还公开了制备这些组合物的方法以及通过给予这些组合物来缓解由压力引起的损伤或能量代谢紊乱的方法。
• Formulations and methods for treatment or amelioration of inflammatory conditions
  申请人：Phinney Dodge Stephen

  公开号：US20050137253A1

  公开（公告）日：2005-06-23

  Formulations and methods for the treatment and/or amelioration of symptoms of inflammatory conditions and associated systemic inflammatory responses are described herein. The compositions comprise a non-alpha tocopherol (especially gamma-, beta-, or delta-tocopherol) and one or more of an omega-3 fatty acid, such as docosahexaenoic acid (DHA) or a flavonoid.

  本文描述了用于治疗和/或改善炎症状和相关全身炎症反应的配方和方法。这些组合物包括非α-生育酚（特别是γ-、β-或δ-生育酚）和一种或多种ω-3脂肪酸，例如二十二碳六烯酸（DHA）或类黄酮。
• Oxidative Färbemittel
  申请人：Henkel AG & Co. KGaA

  公开号：EP2301520A2

  公开（公告）日：2011-03-30

  Gegenstand der vorliegenden Anmeldung sind Mittel zur oxidativen Färbung keratinischer Fasern, insbesondere menschlicher Haare, enthaltend in einem kosmetisch akzeptablen Träger mindestens ein Oxidaionsfarbstoffvorprodukt sowie eine Wirkstoffkombination aus (a) mindestens einer basischen Aminosäure, (b) Pyrrolidoncarbonsäure oder einer ihrer physiologisch verträglichen Salze, wobei die Mittel im Wesentlichen frei von sauren Aminosäuren sind.

  本申请涉及用于角质纤维（尤其是人类头发）氧化染色的组合物，该组合物在 美容上可接受的载体中包含至少一种氧化染色前体和以下活性成分组合 (a) 至少一种碱性氨基酸、 (b) 吡咯烷酮羧酸或其生理上可接受的盐、 其中的制剂基本上不含酸性氨基酸。
• Compositions and methods for the prevention and treatment of tissue ischemia
  申请人：——

  公开号：US20020132845A1

  公开（公告）日：2002-09-19

  The present invention provides compositions and methods for the treatment of tissue ischemia, and in particular, cerebral ischemia. In particular, the present invention provides gamma-, beta-, or delta-tocopherol enriched tocopherol compositions and gamma-, beta-, or delta-tocopherol metabolite enriched compositions and/or flavonoid enriched and/or a flavonoid derivative enriched compositions and methods for their use in preventing or treating a tissue ischemic condition or a cerebral ischemic condition. The present invention also provides pharmaceutical compositions comprising gamma-, beta-, or delta-tocopherol enriched tocopherol composition, a gamma-, beta-, or delta-tocopherol metabolite enriched compositions or flavonoid enriched compositions or flavonoid derivative enriched compositions.

  本发明提供了治疗组织缺血，特别是脑缺血的组合物和方法。特别是，本发明提供了γ-、β-或δ-生育酚富集生育酚组合物和γ-、β-或δ-生育酚代谢物富集组合物和/或黄酮类富集和/或黄酮类衍生物富集组合物和方法，用于预防或治疗组织缺血病症或脑缺血病症。本发明还提供了包含γ-、β-或δ-生育酚富集生育酚组合物、γ-、β-或δ-生育酚代谢物富集组合物或类黄酮富集组合物或类黄酮衍生物富集组合物的药物组合物。
• Compositions and methods for reduction of inflammatory symptoms and/or biomarkers in female subjects
  申请人：——

  公开号：US20040048919A1

  公开（公告）日：2004-03-11

  Medicaments and methods for the treatment and/or amelioration of certain inflammatory symptoms related to premenstrual syndrome (PMS), premenstrual dysphoric disorder (PMDD), perimenopause, menopause, endometriosis, post-partum depression, or administration of hormonal contraceptives are described herein. Medicaments of the invention comprise a tocopherol, an omega-3 polyunsaturated fatty acid, such as docosahexaenoic acid (DHA), or omega-9 polyunsaturated fatty acid, optionally, a flavonoid, and, optionally, a mineral, such as magnesium. Methods for treating or ameliorating such symptoms and methods for reducing elevated CRP and/or white blood cell (WBC) associated with such conditions using medicaments of the invention are also described.

  本文描述了用于治疗和/或改善与经前期综合征（PMS）、经前期情感障碍（PMDD）、围绝经期、更年期、子宫内膜异位症、产后抑郁或服用激素避孕药有关的某些炎症症状的药物和方法。本发明的药物包括生育酚、ω-3 多不饱和脂肪酸（如二十二碳六烯酸 (DHA)）或ω-9 多不饱和脂肪酸、可选的类黄酮，以及可选的矿物质（如镁）。还描述了使用本发明药物治疗或改善此类症状的方法以及降低与此类病症相关的 CRP 和/或白细胞（WBC）升高的方法。