(14R)-14-hydroxy-6-O-methylerythromycine A | 116836-41-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (14R)-14-hydroxy-6-O-methylerythromycine A
• 英文别名: (14R)-14-hydroxyclarithromycin；14(R)-hydroxy-clarithromycin；14-(R)-hydroxyclarithromycin；14-hydroxyclarithromycin；(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-(((2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-12,13-dihydroxy-4-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-14-((R)-1-hydroxyethyl)-7-methoxy-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione；(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-12,13-dihydroxy-14-[(1R)-1-hydroxyethyl]-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-7-methoxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione
• CAS: 116836-41-0
• 化学式: C₃₈H₆₉NO₁₄
• 分子量: 763.964
• InChiKey: BLPFDXNVUDZBII-KTDRUCRASA-N

物化性质

• 沸点：
  832.1±65.0 °C(Predicted)
• 密度：
  1.21±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  53
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  203
• 氢给体数：
  5
• 氢受体数：
  15

反应信息

• 作为反应物：
  描述：

  (14R)-14-hydroxy-6-O-methylerythromycine A 在 potassium carbonate 作用下， 以 甲醇 为溶剂， 反应 48.0h， 生成 (1S,2R,3R,6R,7S,8S,9R,10R,12R,14R,15R)-9-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2,13,15-trihydroxy-7-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-10-methoxy-1,3,6,8,10,12,14-heptamethyl-4,16-dioxabicyclo[11.2.1]hexadecan-5-one 、 (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R,15R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-12,13,14-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-7-methoxy-3,5,7,9,11,13,15-heptamethyl-oxacyclopentadecane-2,10-dione
  参考文献：
  名称：

  15-Membered macrolides via translactonization in 14-hydroxy-6-O-methylerythromycin A

  摘要：

  DOI：

  10.1021/jo00275a051

文献信息

• ADACHI, TAKASHI, J. ORG. CHEM., 54,(1989) N4, C. 3507-3510
  作者：ADACHI, TAKASHI

  DOI：——

  日期：——