alpha-D-半乳糖醛酸 1-磷酸酯锂盐 | 58865-20-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: alpha-D-半乳糖醛酸 1-磷酸酯锂盐
• 中文别名: alpha-D-半乳糖醛酸1-磷酸酯锂盐
• 英文名称: α-D-galactopyranosyluronic acid phosphate
• 英文别名: α-D-galactopyranuronic acid 1-phosphate；galacturonic acid 1-phosphate；galacturonic acid-1-phosphate；ο-D-GalA-1-P；GalA-1-P；1-phospho-alpha-D-galacturonic acid；(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-phosphonooxyoxane-2-carboxylic acid
• CAS: 58865-20-6
• 化学式: C₆H₁₁O₁₀P
• 分子量: 274.121
• InChiKey: AIQDYKMWENWVQJ-DTEWXJGMSA-N

物化性质

• 沸点：
  685.1±65.0 °C(Predicted)
• 密度：
  2.05±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -3.4
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  174
• 氢给体数：
  6
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  氨甲酸,(2-氟环丙基)-,1,1-二甲基乙基酯,顺-(9CI) 在 recombinant Bifidobacterium infantis galactokinase 、 5’-三磷酸腺苷 、 magnesium chloride 作用下， 以 aq. buffer 为溶剂， 以92%的产率得到alpha-D-半乳糖醛酸 1-磷酸酯锂盐
  参考文献：
  名称：

  Improved one-pot multienzyme (OPME) systems for synthesizing UDP-uronic acids and glucuronides

  摘要：

  高效的一锅多酶（OPME）系统已经建立起来，用于从简单单糖合成UDP-GlcA、UDP-GalA和葡萄糖醛酸酯。

  DOI：

  10.1039/c4cc10306h

文献信息

• Efficient chemoenzymatic synthesis of novel galacto-N-biose derivatives and their sialylated forms
  作者：Lei Li、Yonghui Liu、Tiehai Li、Wenjun Wang、Zaikuan Yu、Cheng Ma、Jingyao Qu、Wei Zhao、Xi Chen、Peng G. Wang

  DOI：10.1039/c5cc03746h

  日期：——

  Novel galacto-N-biose derivatives and their sialylated form were efficiently synthesizedviaone-pot two-enzyme systems starting with monosaccharides.

  通过单糖开始，使用一锅两酶系统高效合成了新型半乳糖-N-生物素衍生物及其唾液酸化形式。

• A highly efficient galactokinase from Bifidobacterium infantis with broad substrate specificity
  作者：Lei Li、Yonghui Liu、Wenjun Wang、Jiansong Cheng、Wei Zhao、Peng Wang

  DOI：10.1016/j.carres.2012.04.022

  日期：2012.7

  Galactokinase (GalK), particularly GalK from Escherichia coli, has been widely employed for the synthesis of sugar-1-phosphates. In this study, a GalK from Bifidobacterium infantis ATCC 15697 (BiGalK) was cloned and over-expressed with a yield of over 80 mg/L cell cultures. The k(cat)/K-m value of recombinant BiGalK toward galactose (164 s (1) mM (1) ) is 296 times higher than that of GalK from E. coli, indicating that BiGalK is much more efficient in the phosphorylation of galactose. The enzyme also exhibits activity toward galacturonic acid, which has never been observed on other wild type GalKs. Further activity assays showed that BiGalK has broad substrate specificity toward both sugars and phosphate donors. These features make BiGalK an attractive candidate for the large scale preparation of galactose-1-phosphate and derivatives. (C) 2012 Elsevier Ltd. All rights reserved.
• Biomarkers Of Metabolic Responses To Hepatotoxicants And Carcinogens
  申请人：Berger Alvin

  公开号：US20080176266A1

  公开（公告）日：2008-07-24

  Methods for the measurement and prediction of response to hepatotoxicants and carcinogens through the detection of metabolites in a mammal are provided. The metabolites can be used as biomarkers, including efficacy biomarkers, surrogate biomarkers, and toxicity biomarkers. The methods find use for early prediction of toxicity, target identification/validation, and monitoring of drug efficacy.
• Probe Compound for Detecting and Isolating Enzymes and Means and Methods Using the Same
  申请人：Golyshin Peter N.

  公开号：US20120231972A1

  公开（公告）日：2012-09-13

  The present invention relates to a probe compound that can comprise any substrate or metabolite of an enzymatic reaction in addition to an indicator component, such as, for example, a fluorescence dye, or the like. Moreover, the present invention relates to means for detecting enzymes in form of an array, which comprises any number of probe compounds of the invention which each comprise a different metabolite of interconnected metabolites representing the central pathways in all forms of life. Moreover, the present invention relates to a method for detecting enzymes involving the application of cell extracts or the like to the array of the invention which leads to reproducible enzymatic reactions with the substrates. These specific enzymatic reactions trigger the indicator (e.g. a fluorescence signal) and bind the enzymes to the respective cognate substrates. Moreover, the invention relates to means for isolating enzymes in form of nanoparticles coated with the probe compound of the invention. The immobilisation of the cognate substrates or metabolites on the surface of nanoparticles by means of the probe compounds allows capturing and isolating the respective enzyme, e.g. for subsequent sequencing.
• [EN] PROBE COMPOUND FOR DETECTING AND ISOLATING ENZYMES AND MEANS AND METHODS USING THE SAME<br/>[FR] COMPOSÉ SONDE POUR DÉTECTER ET ISOLER DES ENZYMES ET MOYENS ET PROCÉDÉS POUR L'UTILISER
  申请人：HELMHOLTZ INFEKTIONSFORSCHUNG

  公开号：WO2010105851A1

  公开（公告）日：2010-09-23

  The present invention relates to a probe compound that can comprise any substrate or metabolite of an enzymatic reaction in addition to an indicator component, such as, for example, a fluorescence dye, or the like. Moreover, the present invention relates to means for detecting enzymes in form of an array, which comprises any number of probe compounds of the invention which each comprise a different metabolite of interconnected metabolites representing the central pathways in all forms of life. Moreover, the present invention relates to a method for detecting enzymes involving the application of cell extracts or the like to the array of the invention which leads to reproducible enzymatic reactions with the substrates. These specific enzymatic reactions trigger the indicator (e.g. a fluorescence signal) and bind the enzymes to the respective cognate substrates. Moreover, the invention relates to means for isolating enzymes in form of nanoparticles coated with the probe compound of the invention. The immobilisation of the cognate substrates or metabolites on the surface of nanoparticles by means of the probe compounds allows capturing and isolating the respective enzyme, e.g. for subsequent sequencing.