N-n-octadecanoyl methyl (L)-tryptophanate | 103583-16-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-n-octadecanoyl methyl (L)-tryptophanate
• 英文别名: stearic-Trp-OMe；N-stearoyltryptophan methyl ester；methyl (2S)-3-(1H-indol-3-yl)-2-(octadecanoylamino)propanoate
• CAS: 103583-16-0
• 化学式: C₃₀H₄₈N₂O₃
• 分子量: 484.723
• InChiKey: NYCSUTVQAXSILO-NDEPHWFRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.8
• 重原子数：
  35
• 可旋转键数：
  21
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  71.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-n-octadecanoyl methyl (L)-tryptophanate 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 反应 10.0h， 以90%的产率得到N-stearoyl-L-tryptophan
  参考文献：
  名称：

  通过使用具有氧化还原活性的两亲物原位合成金和银纳米粒子，并将其相转移到有机溶剂中。

  摘要：

  描述了一种通过在碱性pH下使用一系列新设计的氧化还原活性两亲物来原位合成金和银纳米粒子的方法。这些两亲物是脂肪酸（例如油酸，硬脂酸和月桂酸）和氧化还原活性氨基酸（例如色氨酸或酪氨酸）的缀合物。然后，仅通过酸处理就可以将两亲涂层纳米颗粒从水中有效转移到不同的非极性有机介质（例如苯，甲苯，二甲苯，环己烷和己烷）中。通过紫外/可见光谱和透射电子显微镜监测相转移过程，结果表明，转移到有机介质后，平均粒径和粒径分布几乎保持不变。通过FTIR光谱和热重分析证实了两亲物对纳米颗粒表面的锚定。提出了一种机制来描述原位形成的胶态金纳米粒子和银纳米粒子的稳定性以及它们向有机溶剂中的相转移。两亲物的存在增加了胶体金纳米颗粒共轭物在有机溶剂中的热稳定性。

  DOI：

  10.1002/chem.200701014
• 作为产物：
  描述：

  L-色氨酸 在 氯化亚砜 、 potassium hydrogencarbonate 、 三乙胺 作用下， 以 氯仿 、 水 为溶剂， 反应 11.0h， 生成 N-n-octadecanoyl methyl (L)-tryptophanate
  参考文献：
  名称：

  Molecular mechanism of physical gelation of hydrocarbons by fatty acid amides of natural amino acids

  摘要：

  A variety of fatty acid amides of different naturally occurring L-amino acids have been synthesized and they are found to form gels with various hydrocarbons. The gelation properties of these compounds were studied by a number of physical methods including FTIR spectroscopy, X-ray diffraction, scanning electron microscopy, differential scanning calorimetry, rheology, and it was found that gelation depended critically on the fatty acid chain length and the nature of the amino acid. Among them L-alanine based gelators were found to be the most efficient and versatile gelators as they self-assemble into a layered structure to form the gel network. Mechanisms for the assembly and formation of gels from these molecules are discussed. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.05.028

文献信息

• PHARMACEUTICAL COMPOSITION WITH GELLING PROPERTIES CONTAINING A TYROSINE DERIVATIVE
  申请人：Leroux Jean-Christophe

  公开号：US20110207813A1

  公开（公告）日：2011-08-25

  The present invention relates to an injectable pharmaceutical composition with gelling properties containing:—an active principle; a hydrophobic and bio-compatible organic liquid; and an organogelling substance, the molecules of which have the capacity to bind together via bonds of low energy, wherein said organogelling substance is chosen among L-tyrosine derivatives responding to the following formula (I) wherein: R1 is an alkyl group containing 1 to 3 carbon atoms, linear or branched; and R2 is a hydrophobic group chosen among aliphatic saturated or unsaturated fatty chains or aryl or arylalkyl groups, Its use as a vector for the release of active principles, as well as its process of preparation.
• US8815944B2
  申请人：——

  公开号：US8815944B2

  公开（公告）日：2014-08-26