7-bromo-2,2-dimethylheptanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 7-bromo-2,2-dimethylheptanoic acid
• 英文别名: 2,2-Dimethyl-7-bromo-heptanoic acid
• 化学式: C₉H₁₇BrO₂
• 分子量: 237.137
• InChiKey: JWPJGIYPJDPHSH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,2-dimethyl-8-oxooctanoic acid 、 7-bromo-2,2-dimethylheptanoic acid 在 碘 、 magnesium 作用下， 以 四氢呋喃 为溶剂， 以77%的产率得到贝派地酸
  参考文献：
  名称：

  贝派地酸的制备方法

  摘要：

  本发明揭示了一种贝派地酸(Bempedoic acid)的制备方法，其步骤包括：异丁酸乙酯与2‑(5‑溴正戊基)‑1,3‑二氧环戊烷在碱促进剂作用下发生缩合反应，再经水解反应得到中间体8‑氧杂‑2,2‑二甲基辛酸，该中间体与7‑溴‑2,2‑二甲基庚酸发生格氏反应制得贝派地酸。该制备方法工艺简洁，条件温和，安全环保，为工业化生产提供了一条新途径。

  公开号：

  CN113149829B
• 作为产物：
  描述：

  7-benzyloxy-2,2-dimethylheptanoic acid 在 氢溴酸 、 十六烷基三丁基溴化磷 作用下， 以90 %的产率得到7-bromo-2,2-dimethylheptanoic acid
  参考文献：
  名称：

  CN116410086

  摘要：

  公开号：

文献信息

• [EN] FLAVIN DERIVATIVES<br/>[FR] DÉRIVÉS DE LA FLAVINE
  申请人：BIORELIX PHARMACEUTICALS INC

  公开号：WO2010019208A1

  公开（公告）日：2010-02-18

  The present invention relates novel flavin derivatives and other flavin derivatives, their use and compositions for use as riboswitch ligands and/or anti-infectives. The invention also provides method of making novel flavin derivatives.

  本发明涉及新型黄素衍生物和其他黄素衍生物，它们的用途以及用作核糖开关配体和/或抗感染剂的组合物。该发明还提供了制备新型黄素衍生物的方法。
• Substituted semicarbazone arthropodicides
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0377304A2

  公开（公告）日：1990-07-11

  Semicarbazone compounds of the general formula: wherein: Q is wherein A is a bond or a bridging group; R1-R4 are each H or a substituent group; V is O or S; n is 1 to 4; exhibit arthropodicidal activity.

  通式如下的半咔唑酮化合物 其中 Q 是 其中 A 是键或桥基； R1-R4 均为 H 或取代基； V 是 O 或 S n 为 1 至 4； 具有杀节肢动物活性。
• Thromboxane synthetase inhibitors (TXSI). Design, synthesis, and evaluation of a novel series of .omega.-pyridylalkenoic acids
  作者：Kaneyoshi Kato、Shigenori Ohkawa、Shinji Terao、Zenichi Terashita、Kohei Nishikawa

  DOI：10.1021/jm00381a005

  日期：1985.3

  A novel series of omega-pyridylalkenoic acids has been prepared by applying the Wittig reaction. Modifications were made in the omega-aryl moiety, the alkylene chain length, the alpha-methylene group adjacent to the carbonyl group, and the carboxyl group of the molecule. The compounds were tested as inhibitors of thromboxane synthetase in an in vitro assay and in ex vivo experiments with the rat. Most members of this new class of thromboxane synthetase inhibitors (TXSI) showed good activity in both assay systems. (E)-7-Phenyl-7-(3-pyridyl)-6-heptenoic acid (9c; CV-4151) was one of the most potent compounds in in vitro enzyme inhibition (IC50 = 2.6 X 10(-8) M) and, when orally administered, the most potent and long acting in the inhibition of blood thromboxane A2 production in the rat. New conceptual models I-III for the enzyme-substrate (prostaglandin H2, PGH2) and the enzyme-TXSI interactions are proposed for understanding the molecular design and structure-activity relations.
• SUBSTITUTED BICYCLIC BIS-ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B 4? ANTAGONIST ACTIVITY, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS
  申请人：RHONE-POULENC RORER S.A.

  公开号：EP0540604A1

  公开（公告）日：1993-05-12
• US5182303A
  申请人：——

  公开号：US5182303A

  公开（公告）日：1993-01-26