双酚A二甲醚 | 1568-83-8

• 物质功能分类: 化学试剂 - 有机试剂 - 醚类
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 双酚A二甲醚
• 英文名称: 2,2-bis(4-methoxyphenyl)propane
• 英文别名: 1-methoxy-4-[1-(4-methoxyphenyl)-1-methylethyl]benzene；2,2'-bis(4-methoxyphenyl)propane；bisphenol A dimethyl ether；dimethyl-bisphenol A；methoxybisphenol A；dimethyl BPA；Benzene, 1,1'-(1-methylethylidene)bis[4-methoxy-；1-methoxy-4-[2-(4-methoxyphenyl)propan-2-yl]benzene
• CAS: 1568-83-8
• 化学式: C₁₇H₂₀O₂
• mdl: MFCD00984727
• 分子量: 256.345
• InChiKey: OJYIBEYSBXIQOP-UHFFFAOYSA-N

物化性质

• 熔点：
  54-59 °C
• 沸点：
  359.58°C (rough estimate)
• 密度：
  1.0421 (rough estimate)
• 保留指数：
  2111
• 稳定性/保质期：

  在常温常压下，该物质是稳定的。

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.294
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S37/39
• 危险类别码：
  R36/37/38
• 海关编码：
  2909309090
• 储存条件：
  密封储存，应存放在阴凉干燥的库房中。

SDS

Name:	Bisphenol A Dimethylether 98% Material Safety Data Sheet
Synonym:	4,4'-Isopropylidinediphenol Dimethylethe
CAS:	1568-83-8

Section 1 - Chemical Product MSDS Name:Bisphenol A Dimethylether 98% Material Safety Data Sheet
Synonym:4,4'-Isopropylidinediphenol Dimethylethe

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
1568-83-8	Bisphenol A Dimethylether	98%	unlisted

Hazard Symbols: XI
Risk Phrases: 36/37/38

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin.
Potential Health Effects
Eye:
Causes eye irritation. May cause chemical conjunctivitis.
Skin:
Causes skin irritation.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea.
Inhalation:
Causes respiratory tract irritation. Can produce delayed pulmonary edema.
Chronic:
Effects may be delayed.

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Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation.
Notes to Physician:
Treat symptomatically and supportively.

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

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Section 7 - HANDLING and STORAGE
Handling:
Minimize dust generation and accumulation. Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing.
Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Wash clothing before reuse.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 1568-83-8: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Crystalline powder
Color: white to off-white
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 58-60 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: Insoluble.
Specific Gravity/Density:
Molecular Formula: C17H20O2
Molecular Weight: 256.14

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Incompatible materials, dust generation, excess heat.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 1568-83-8 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
Bisphenol A Dimethylether - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 37/39 Wear suitable gloves and eye/face
protection.
WGK (Water Danger/Protection)
CAS# 1568-83-8: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 1568-83-8 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 1568-83-8 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

二甲基双酚A（DMBPA）是一种有效的HIF-1α抑制剂，可以降低Vegfa mRNA的表达。

反应信息

• 作为反应物：
  描述：

  双酚A二甲醚 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 以93%的产率得到双酚A
  参考文献：
  名称：

  通过光驱动 C-C 键裂解对羟基化聚合物进行解聚

  摘要：

  环境中持久性塑料废物的积累被广泛认为是一种生态危机。新的化学技术对于将现有的塑料废物流回收成高价值的化学原料和开发可按设计降解的下一代材料都是必要的。在这里，我们报告了一种催化方法，用于在接近环境温度的可见光照射下解聚商业苯氧基树脂和高分子量羟基化聚烯烃衍生物。沿着聚合物主链周期性间隔的羟基的质子耦合电子转移 (PCET) 活化提供了反应性烷氧基自由基，通过 C-C 键 β 断裂促进链断裂。解聚产生定义明确且可分离的产物混合物，这些混合物易于多样化为缩聚单体。除了控制解聚外，羟基还调节这些聚烯烃衍生物的热机械性能，从而产生具有多种性能的材料。这些结果证明了一种基于光驱动 C-C 键裂解的聚合物回收新方法，该方法有可能在循环聚合物经济中建立新的联系，并影响新的可设计降解聚烯烃材料的开发。

  DOI：

  10.1021/jacs.1c05330
• 作为产物：
  描述：

  双酚A 、 碘甲烷 在 potassium carbonate 作用下， 以72%的产率得到双酚A二甲醚
  参考文献：
  名称：

  Preparation of 4,13,19,28-Tetrahydroxy-9,9,24,24-tetramethyl[2.1.2.1]metacyclophane, a Novel exo-Hydroxycalixarene Analogue

  摘要：

  一种新型 4,13,19,28- 四羟基-9,9,24,24-四甲基[2.1.2.1]偏环烷由双酚 A 经过六个步骤制备而成，并发现其在固态下具有鞍状结构。

  DOI：

  10.1039/a901502g

文献信息

• COMPOUND COMPRISING PHENYL PYRIDINE UNITS
  申请人：Ye Qing

  公开号：US20090289547A1

  公开（公告）日：2009-11-26

  Organic compounds of formula I may be used in optoelectronic devices wherein R 1 is, independently at each occurrence, a C 1 -C 20 aliphatic radical, a C 3 -C 20 aromatic radical, or a C 3 -C 20 cycloaliphatic radical; R2 is, independently at each occurrence, a C 1 -C 20 aliphatic radical, a C 3 -C 20 aromatic radical, or a C 3 -C 20 cycloaliphatic radical; a is, independently at each occurrence, an integer ranging from 0-4; b is, independently at each occurrence, an integer ranging from 0-3; Ar 1 is a direct bond or heteroaryl, aryl, or alkyl or cycloalkyl; Ar 2 is heteroaryl, aryl, or alkyl or cycloalkyl; c is 0, 1 or 2; and n is an integer ranging from 2-4.

  化学式I的有机化合物可用于光电子器件，其中R1在每次出现时独立地是C1-C20脂肪基、C3-C20芳香基或C3-C20环脂肪基；R2在每次出现时独立地是C1-C20脂肪基、C3-C20芳香基或C3-C20环脂肪基；a在每次出现时独立地是0-4之间的整数；b在每次出现时独立地是0-3之间的整数；Ar1是直接键或杂环芳基、芳基、烷基或环烷基；Ar2是杂环芳基、芳基、烷基或环烷基；c为0、1或2；n是2-4之间的整数。
• [EN] DIGLYCIDIC ETHER DERIVATIVE THERAPEUTICS AND METHODS FOR THEIR USE<br/>[FR] PRODUITS THÉRAPEUTIQUES DÉRIVÉS D'ÉTHERS DIGLYCIDIQUES ET LEURS PROCÉDÉS D'UTILISATION
  申请人：BRITISH COLUMBIA CANCER AGENCY

  公开号：WO2010000066A1

  公开（公告）日：2010-01-07

  This invention provides compound having a structure of Formula I or Formula II. Uses of such compounds for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are also provided.

  这项发明提供了具有化学结构为式I或式II的化合物。还提供了这些化合物用于治疗各种适应症，包括前列腺癌的用途，以及涉及这些化合物的治疗方法。
• An Alternative to the Sandmeyer Approach to Aryl Iodides
  作者：Bao Hu、William H. Miller、Kiel D. Neumann、Ethan J. Linstad、Stephen G. DiMagno

  DOI：10.1002/chem.201500151

  日期：2015.4.20

  compounds through the intermediacy of diaryliodonium salts. This process, which incorporates a phase separation that greatly simplifies product purification, is an attractive replacement for the Sandmeyer approach to iodoarenes that are otherwise difficult to access.

  碘代芳烃是广泛有机转化的重要合成子。在这里，我们报告了通过二芳基碘鎓盐的中间体制备单碘化的富电子芳族化合物的一般策略。该工艺结合了相分离，可大大简化产品纯化，是Sandmeyer方法对碘代芳烃的一种有吸引力的替代方法，否则该方法难以获得。
• A mild and practical method for deprotection of aryl methyl/benzyl/allyl ethers with HPPh₂ and ^<i>t</i>BuOK
  作者：Wenjing Pan、Chenchen Li、Haoyin Zhu、Fangfang Li、Tao Li、Wanxiang Zhao

  DOI：10.1039/d1ob01286j

  日期：——

  demethylation, debenzylation, and deallylation of aryl ethers using HPPh2 and tBuOK is reported. The reaction features mild and metal-free reaction conditions, broad substrate scope, good functional group compatibility, and high chemical selectivity towards aryl ethers over aliphatic structures. Notably, this approach is competent to selectively deprotect the allyl or benzyl group, making it a general and practical

  报道了使用 HPPh 2和t BuOK 对芳基醚进行去甲基化、去苄基化和去烯丙基化的通用方法。该反应具有温和且不含金属的反应条件、广泛的底物范围、良好的官能团相容性以及对芳基醚的化学选择性高于脂肪族结构。值得注意的是，这种方法能够选择性地去保护烯丙基或苄基，使其成为有机合成中通用且实用的方法。
• Cu‐Catalyzed Phenol O‐Methylation with Methylboronic Acid
  作者：Mairead E. Bartlett、Yingchuan Zhu、Uma Bhagwat Gaffney、Joyce Lee、Miranda Wu、Betemariam Sharew、Angela K. Chavez、David J. Gorin

  DOI：10.1002/ejoc.202100902

  日期：2021.11.8

  oxidative cross-coupling of phenols with methylboronic acid provides a synthetic route to aryl methyl ethers, expanding the scope of Chan-Evans-Lam alkylation. The reaction proceeds under “open flask” conditions with no additional oxidant. Electron-deficient phenol derivatives are methylated in high yields, and some N-heterocycles are tolerated.

  Cu催化苯酚与甲基硼酸的氧化交叉偶联提供了合成芳基甲基醚的途径，扩大了Chan-Evans-Lam烷基化的范围。反应在“开放烧瓶”条件下进行，无需额外的氧化剂。缺电子苯酚衍生物以高产率被甲基化，并且可以耐受一些 N-杂环。