1-(4-tert-Butyl-phenyl)-5-hydroxy-3-(3-trifluoromethyl-phenoxy)-1H-indole-2-carboxylic acid ethyl ester | 870459-75-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-(4-tert-Butyl-phenyl)-5-hydroxy-3-(3-trifluoromethyl-phenoxy)-1H-indole-2-carboxylic acid ethyl ester
• CAS: 870459-75-9
• 化学式: C₂₈H₂₆F₃NO₄
• 分子量: 497.514
• InChiKey: CZSXREJIPOBLJH-UHFFFAOYSA-N

物化性质

• 沸点：
  529.2±50.0 °C(Predicted)
• 密度：
  1.23±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.62
• 重原子数：
  36.0
• 可旋转键数：
  5.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  60.69
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  1-(4-tert-Butyl-phenyl)-5-hydroxy-3-(3-trifluoromethyl-phenoxy)-1H-indole-2-carboxylic acid ethyl ester 在 sodium hydroxide 、 caesium carbonate 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 17.0h， 生成 1-(4-tert-Butyl-phenyl)-5-isobutoxy-3-(3-trifluoromethyl-phenoxy)-1H-indole-2-carboxylic acid
  参考文献：
  名称：

  Synthesis and biological activities of novel aryl indole-2-carboxylic acid analogs as PPARγ partial agonists

  摘要：

  A series of novel aryl indole-2-carboxylic acids has been identified as potent selective PPAR gamma modulators. Their chemical synthesis and in vitro activities are discussed. Compound 5 was selected for in vivo testing in the db/db mouse model of type 2 diabetes and resulted in reduction of hyperglycemia at comparable plasma exposure when compared to rosiglitazone. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.08.002
• 作为产物：
  描述：

  1-(4-tert-Butyl-phenyl)-5-methoxy-3-(3-trifluoromethyl-phenoxy)-1H-indole-2-carboxylic acid ethyl ester 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以80%的产率得到1-(4-tert-Butyl-phenyl)-5-hydroxy-3-(3-trifluoromethyl-phenoxy)-1H-indole-2-carboxylic acid ethyl ester
  参考文献：
  名称：

  Synthesis and biological activities of novel aryl indole-2-carboxylic acid analogs as PPARγ partial agonists

  摘要：

  A series of novel aryl indole-2-carboxylic acids has been identified as potent selective PPAR gamma modulators. Their chemical synthesis and in vitro activities are discussed. Compound 5 was selected for in vivo testing in the db/db mouse model of type 2 diabetes and resulted in reduction of hyperglycemia at comparable plasma exposure when compared to rosiglitazone. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.08.002