6-methoxy-5,8-bis(4'-amino-1'-methylbutylamino)quinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-methoxy-5,8-bis(4'-amino-1'-methylbutylamino)quinoline
• 英文别名: 5-N,8-N-bis(5-aminopentan-2-yl)-6-methoxyquinoline-5,8-diamine
• 化学式: C₂₀H₃₃N₅O
• 分子量: 359.515
• InChiKey: YHSZCMSYNLAQGR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  26
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  98.2
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  伯氨喹 在 dipotassium peroxodisulfate 作用下， 反应 0.67h， 生成 6-methoxy-5,8-bis(4'-amino-1'-methylbutylamino)quinoline 、 5,8-di-(4'-amino-1'-methylbutylamino)-6,7-dihydroxyquinoline 、 5,5-bis[6-methoxy-8-('-amino-1'-methylbutylamino)quinoline] 、 5,5-bis[7-hydroxy-6-methoxy-8-(4'-amino-1'-methylbutylamino)quinoline]
  参考文献：
  名称：

  Isolation and antimalarial activity of peroxydisulfate oxidation products of primaquine

  摘要：

  Five compounds formed by peroxydisulfate oxidation of primaquine were isolated using chromatographic methods and evaluated for antimalarial activity in vitro. One compound 6-methoxy-5,8 bis(4'-amino-1'-methylbutylamino)quinoline [P-1] was found to have good gametocytocidal activity against Plasmodium yoelli infected mice at 10 mg kg(-1) dose in vivo. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00802-8

文献信息

• Isolation and antimalarial activity of peroxydisulfate oxidation products of primaquine
  作者：Virendra K Dua、Sukesh N Sinha、Sukla Biswas、N Valecha、S.K Puri、V.P Sharma

  DOI：10.1016/s0960-894x(02)00802-8

  日期：2002.12

  Five compounds formed by peroxydisulfate oxidation of primaquine were isolated using chromatographic methods and evaluated for antimalarial activity in vitro. One compound 6-methoxy-5,8 bis(4'-amino-1'-methylbutylamino)quinoline [P-1] was found to have good gametocytocidal activity against Plasmodium yoelli infected mice at 10 mg kg(-1) dose in vivo. (C) 2002 Elsevier Science Ltd. All rights reserved.